Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension

Thorax

Volumn 51, Issue 1, 1996, Pages 89-91

  Brett, Stephen J ^a   Gibbs, J Simon R ^a   Pepper, John R ^a   Evans, Timothy W ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Endothelium; Primary pulmonary hypertension

Indexed keywords

ADENOSINE; SUBSTANCE P;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ETIOLOGY; HUMAN; LUNG HEMODYNAMICS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

EID: 0030053104     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.51.1.89     Document Type: Article

References (10)

1. Rich S. Primary pulmonary hypertension. Prog Cardiovasc Dis 1988;31:205-38.
2. Liu SF, Crawley DG, Barnes PJ, Evans TW. Endothelium-derived relaxant factor modulates hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lungs. Am Rev Respir Dis 1991;143:32-7.
3. Loscalzo JL. Endothelial dysfunction in pulmonary hypertension. N Engl J Med 1992;327:117-9.
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5. Evans TW, Dixon CMS, Clarke B, Conradson TB, Barnes PJ. Comparison of neurokinin A and substance P on cardiovascular and airway function in man. Br J Clin Pharmacol 1988;25:273-6.
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9. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J. Inhaled nitric oxide as a cause of selective vasodilation in patients with primary pulmonary hypertension. Lancet 1991;338:1173-4.
10. Rich S, Kaufman E, Levy PS. The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension. N Engl J Med 1992;327:76-81.