Influence of human leukocyte antigen and tumour necrosis factor genes on the development of pre-eclampsia

Human Reproduction Update

Volumn 5, Issue 2, 1999, Pages 94-102

  Kilpatrick, David C ^a  

^a Academic Unit   (United Kingdom)

Author keywords

HLA DR; Pre eclampsia; Pregnancy hypertension; Tumour necrosis factor

Indexed keywords

HLA ANTIGEN; HLA DR4 ANTIGEN; PHOSPHOLIPID ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANTIPHOSPHOLIPID SYNDROME; FEMALE; GENETIC SUSCEPTIBILITY; HISTOCOMPATIBILITY GENE; HLA SYSTEM; HUMAN; MATERNAL HYPERTENSION; PREECLAMPSIA; PRIORITY JOURNAL; REVIEW;

ANTIPHOSPHOLIPID SYNDROME; FEMALE; FETUS; GENE EXPRESSION REGULATION; HAPLOTYPES; HLA ANTIGENS; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PRE-ECLAMPSIA; PREGNANCY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032908757     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/5.2.94     Document Type: Review

References (96)

1. Adams, E.M. and Findlayson, A. (1961) Familial aspects of pre-eclampsia and hypertension in pregnancy. Lancet, ii, 1375-1378.
2. Arngrimsson, R. (1990) Inheritance and family patterns in preeclampsia and eclampsia. Contemp. Rev. Obstet. Gynaecol., 2, 152-158.
3. Arngrimsson, R., Bjornsson, S., Geirsson, R.T. et al. (1990) Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br. J. Obstet. Gynaecol., 97, 762-769.
4. Arngrimsson, R., Bjornsson, S. and Geirsson, R.T. (1995) Analysis of different inheritance patterns in pre-eclampsia/eclampsia syndrome. Hypertension Pregnancy, 14, 27-38.
5. Arngrimsson, R., Hayward, C., Nadavd, S. et al. (1997) Evidence fora familial pregnancy-induced hypertension locus in the eNOS-gene region. Am. J. Hum. Genet., 61, 354-362.
6. Artlett, C., Smith, J.B. and Jimenez, S. (1998) Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis. New Engl. J. Med., 338, 1186-1191.
7. Bendtzen, K., Morling, N., Fomsgaard, A. et al. (1988) Association between HLA-DR2 and production of tumour necrosis factor α and interleukin 1 by mononuclear cells activated by lipopolysaccharide. Scand. J. Immunol., 28, 599-606.
8. Bianchi, D.W., Zickwolf, G.K., Weil, G.J. et al. (1996) Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA, 93, 705-708.
9. Bouma, G., Crusius, J.B.A., Oudkerk-Pool, M. et al. (1996) Secretion of tumour necrosis factor and lymphocytotoxin in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease. Scand. J. Immunol. 43, 456-463.
10. Boyd, P.A., Lindenbaum, R.H. and Redman, C. (1987) Pre-eclampsia and trisomy 13: a possible association. Lancet, ii, 425-427.
11. Camps, M.T., Cuadrado, M.J., Ocon, P. et al. (1995) Association between HLA-class II antigens and primary antiphospholipid syndrome from the South of Spain. Lupus, 4, 52-55.
12. Carosella, E.D., Dausset, J. and Kirszenbaum, M. (1996) HLA-G revisited. Immunol. Today, 17, 407-409.
13. Cassidy, S., Lester, S., Humphreys, G. et al. (1995) A new HLA-DRB1*04 allele: DRB1*0420. Tissue Antigens. 45, 353-355.
14. Chen, G., Wilson, R., Wang, S.H. et al. (1996) Tumour necrosis factor-alpha (TNF-α) gene polymorphism and expression in pre-eclampsia. Clin. Exp. Immunol., 104, 154-159.
15. Chesley, L.C. and Cooper, D.N. (1986) Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Br. J. Obstet. Gynaecol., 93, 898-908.
16. Chesley, L.C., Cosgrove, R.A. and Annitto, J.E. (1961) Pregnancy in the sisters and daughters of eclamptic women. Pathol. Microbiol., 24, 662-666.
17. Chesley, L.C., Annitto, J.E. and Cosgrove, R.A. (1968) Familial factor in toxaemia of pregnancy. Obstet. Gynecol., 32, 303-311.
18. Claas, F.J.H., Gijbels, Y., van der Velden-de-Munck, J. and van Rood, J.J. (1988) Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science, 241, 1815-1817.
19. Cockell, A.P., Learmont, J.G., Smarason, A.K. et al. (1997) Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function. Br. J. Obstet. Gynaecol., 104, 235-240.
20. Cooper, D.W. and Liston, W.A. (1979) Genetic control of severe pre-eclampsia. J. Med. Genet., 16, 409-416.
21. Cooper, D.W., Hill, J.A., Chesley, L.C. et al. (1988) Genetic control of susceptibility to eclampsia and miscarriage. Br. J. Obstet. Gynaecol., 95, 644-653.
22. Dizon-Townson, D.S., Nelson, L.M., Easton, K. et al. (1996) The factor V Leiden mutation may predispose women to severe preeclampsia. Am. J. Obstet. Gynecol., 175, 902-905.
23. Douglas, K.A. and Redman, C.W.G. (1994) Eclampsia in the United Kingdom. Br. Med. J., 309, 1395-1400.
24. Fried, M., Muga, R.O., Misore, A.O. et al. (1998) Malaria elicits type 1 cytokines in the human placenta: IFNγ and TNF-α associated with pregnancy outcomes. J. Immunol., 160, 2523-2530.
25. Grandone, E., Margaglione, M., Colaizzo, D. et al. (1997) Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb. Haemostasis, 77, 1052-1054.
26. Hamai, Y., Fujii, T., Yamashita, T. et al. (1977) Evidence for an elevation in serum interleukin-2 and tumour necrosis factor-alpha levels before the clinical manifestations of pre-eclampsia. Am. J. Reprod. Immunol., 38, 89-93.
27. Harrison, G.A., Humphrey, K.E., Jones, N. et al. (1997) A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am. J. Hum. Genet., 60, 1158-1167.
28. Hayward, C., Gilfillan, A., Livingstone, J. et al. (1990) HLA-DR and pre-eclampsia in Edinburgh. Lancet, 335, 1458-1459.
29. Hayward, C., Livingstone, J., Holloway, S. et al. (1992) An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance. Am. J. Hum. Genet., 50, 749-758.
30. Hoff, C., Stevens, R.G., Mendenhall, H. et al. (1990) Association between risk for pre-eclampsia and HLA-DR4. Lancet, 335, 660-661.
31. Hoff, C., Peevy, K.J., Giattina, K. et al. (1992) Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension. Obstet. Gynecol., 80, 1007-1012.
32. Hoff, C., Peevy, K.J., Spinato, J.A. et al. (1993) Association between maternal-fetal HLA-DR relationships and fetal growth. Am. J. Reprod. Immunol., 30, 246-253.
33. Humphrey, K.E., Harrison, G.A., Cooper, D.W. et al. (1995) HLA-G deletion polymorphism and pre-eclampsia/eclampsia. Br. J. Obstet. Gynaecol., 102, 707-710.
34. Jacob, C.O., Fronek, Z., Lewis, G.D. et al. (1990) Heritable major histocompatibility complex class II-associated differences in production of tumour necrosis factor α: relevance to genetic predisposition to systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA, 87, 1233-1237.
35. Jazwinska, E.C. and Kilpatrick, D.C. (1987) Haplotype frequencies in South-East Scotland. Tissue Antigens, 29, 115-119.
36. Jazwinska, E.C., Kilpatrick, D.C., Smart, G.E. and Liston, W.A. (1987) Fetomaternal HLA compatibility does not have a major influence on human pregnancy except for lymphocytotoxin production. Clin. Exp. Immunol., 69, 116-122.
37. Jenkins, D.M., Need, J.A. and Rajah, S.M. (1977) Deficiency of specific HLA antibodies in severe pregnancy pre-eclampsia/eclampsia. Clin. Exp. Immunol., 27, 485-486.
38. Jenkins, D.M., Need, J.A., Scott, J.S. et al. (1978) Human leucocyte antigens and mixed lymphocyte reactions in severe pre-eclampsia. Br. Med. J., 1, 542-544.
39. Johnstone, N. and Moodley, J. (1989) Genetic control of susceptibility to eclampsia and miscarriage. Br. J. Obstet. Gynaecol., 96, 369-372.
40. Johnstone, N., Moodley, J. and Hammond, M.G. (1988) Human leucocyte antigen status in African women with eclampsia. Br. J. Obstet. Gynaecol., 95, 877-879.
41. 2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum. Reprod., 11, 509-512.
42. Kilpatrick, D.C. (1991) Pre-eclampsia and anti-phospholipid antibody. Br. J. Obstet. Gynaecol., 98, 1313-1314.
43. Kilpatrick, D.C. (1996) HLA-dependent TNF secretory response may provide an immunogenetic link between pre-eclampsia and type 1 diabetes mellitus. Disease Markers, 13, 43-47.
44. Kilpatrick, D.C. and Liston, W.A. (1992) Obstetric significance of cardiolipin antibodies in subjects without systemic lupus erythematosis. J. Obstet. Gynaecol., 12, 82-86.
45. Kilpatrick, D.C. and Liston, W.A. (1993) Influence of histocompatibility antigens in recurrent spontaneous abortion and its relevance to leukocyte immunotherapy. Hum. Reprod., 8, 1645-1649.
46. Kilpatrick, D.C., Liston, W.A., Jazwinska, E.C. and Smart, G.E. (1987a) Histocompatibility studies in pre-eclampsia. Tissue Antigens, 29, 232-236.
47. Kilpatrick, D.C., Jazwinska, E.C., Liston, W.A. and Smart, G.E. (1987b) Severe pre-eclampsia in multiparous women: indication of an environmental triggering agent? Scot. Med. J., 32, 8-10.
48. Kilpatrick, D.C., Gibson, F., Liston, W.A. and Livingstone, J. (1989) Association between susceptibility to pre-eclampsia within families and HLA-DR4. Lancet, ii, 1063-1065.
49. Kilpatrick, D.C., Gibson, F., Livingstone, J. and Liston, W.A. (1990) Pre-eclampsia is associated with HLA-DR4 sharing between mother and fetus. Tissue Antigens, 35, 178-181.
50. Kilpatrick, D.C., Hague, R.A., Yap, P.L. and Mok, J.Y.Q. (1991) HLA antigen frequencies in children born to HIV-infected mothers. Disease Markers, 9, 21-26.
51. King, A., Boocock, C., Sharkey, A. et al. (1996) Evidence for the expression of HLA-C class I in RNA and protein by human first trimester trophoblast. J. Immunol., 156, 2068-2076.
52. Larrabee, K.D. and Monga, M. (1997) Women with sickle cell trait are at increased risk for preeclampsia. Am. J. Obstet. Gynaecol., 177, 425-428.
53. Lie, R.T., Rasmussen, S., Brunborg, H. et al. (1998) Fetal and maternal contributions to risk of pre-eclampsia: population based study. Br. Med. J., 316, 1343-1347.
54. Liston, W.A. and Kilpatrick, D.C. (1991) Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? Br. J. Obstet. Gynaecol., 98, 1079-1086.
55. Lo, E.S.F. (1998) Transfer of nucleated maternal cells into fetal circulation during the second trimester of pregnancy. Br. J. Haematol., 100, 605-618.
56. Loke, Y.W., King, A., Burrows, T. et al. (1997) Evaluation of trophoblast HLA-G antigen with a specific monoclonal antibody. Tissue Antigens, 50, 135-146.
57. MacGillivray, I. (1983) Pre-eclampsia. The Hypertensive Disease of Pregnancy. W.B. Saunders, London.
58. Maxwell, C., Kilpatrick, D.C., Haining, R. and Smith, S.K. (1989) No HLA-DR specificity is associated with endometriosis. Tissue Antigens, 34, 145-147.
59. Meekins, J.W., Piznenburg, R., Hanssens, M. et al. (1994a) A study of placental bed spinal arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br. J. Obstet. Gynaecol. 101, 669-674.
60. Meekins, J.W., McLaughlin, P.J., West, D.C. et al. (1994b) Endothelial cell activation by tumour necrosis factor-alpha (TNF-α) and the development of pre-eclampsia. Clin. Exp. Immunol., 98, 110-114.
61. Morales, P., Corell, A., Martinez-Laso, J. et al. (1993) Three new HLA-G alleles and their linkage disequilibrium with HLA-A. Immunogenetics, 38, 323-331.
62. Nelson, J.L., Furst, D., Maloney, S. et al. (1998) Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet, 351, 559-562.
63. Ness, R.B. and Roberts, J.M. (1996) Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am. J. Obstet. Gynecol., 175, 1365-1370.
64. Nuki, G. (1998) Ankylosing spondylitis, HLA-B27 and beyond. Lancet, 351, 767-768.
65. Obsjon, S.L., Novick, D., Wathen, N.C. et al. (1995a) Soluble tumor necrosis factor receptors and soluble interleukin-6 receptor in fetal and maternal sera, coelomic and amniotic fluids in normal and pre-eclamptic pregnancies. J. Reprod. Immunol., 29, 119-134.
66. Obsjon, S.L., Austgulen, R. and Waage, A. (1995b) Interleukin-1, interleukin-6 and tumour necrosis factor at delivery in preeclamptic disorders. Acta Obstet. Gynecol. Scand., 74, 19-26.
67. Pattison, N.S., Chomley, L.W., McKay, E.J. et al. (1993) Antiphospholipid antibodies in pregnancy: prevalence and clinical association. Br. J. Obstet. Gynaecol., 100, 909-913.
68. Peces, R., Urra, J.M. and de la Torre, M. (1995) Influence of HLA-DR phenotype on tumour necrosis factor-alpha. Production in renal-transplant recipients. Nephron, 71, 180-183.
69. Persitz, E., Oksenberg, J., Amar, A. et al. (1983) Histocompatilibty antigens, mixed lymphocyte reactivity and severe preeclampsia in Israel. Gynecol. Obstet. Invest., 16, 283-291.
70. Peterson, R.D.A., Tuck-Muller, C.M., Spinnato, J.A. et al. (1994) An HLA-haplotype associated with pre-eclampsia and intrauterine growth retardation. Am. J. Reprod. Immunol., 31, 177-179.
71. Pociot, F., Briant, L., Jongeneel, C.V. et al. (1993) Association of tumour necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur. J. Immunol., 23, 224-231.
72. Raghupathy, R. (1997) Th 1-type immunity is incompatible with successful pregnancy. Immunol. Today, 18, 4678-4682.
73. Redman, C.W.G., Bodmer, W.F., Bodmer, J.G. et al. (1978) HLA antigens in severe pre-eclampsia. Lancet, ii, 397-399.
74. Schiff, E., Friedman, S.A., Baumann, P. et al. (1994) Tumor necrosis factor-a in pregnancies associated with pre-eclampsia or small-for-gestation-age newborns. Am. J. Obstet. Gynecol., 170, 1224-1229.
75. Schneider, K., Knutson, F., Tamsen, L. and Sjoberg, O. (1994) HLA antigen sharing in preeclampsia. Gynaecol. Obstet. Invest., 37, 87-90.
76. Scott, J.R., Beer, A.E. and Stastny, P. (1976) Immmunogenetic factors in preeclampsia and eclampsia. J. Am. Med. Assoc., 235, 402-404.
77. Shapiro, S.S. (1996) The lupus anticoagulant/antiphospholipid antibody syndrome. Annu. Rev. Med., 47, 533-553.
78. Simon, P., Fauchet, R., Menault, M. et al. (1980) HLA-A,B and DR antigens in pre-eclampsia: preliminary results. Kidney Int., 17, 705-706.
79. Simon, P., Fauchet, R., Pilarge, M. et al. (1988) Association of HLA DR4 with the risk of recurrence of pregnancy hypertension. Kidney Int., 34 (Suppl. 25), S125-S128.
80. Sohda, S., Arinami, T., Hamada, H. et al. (1997) Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J. Med. Genet., 34, 525-526.
81. Stallmach, T., Hebisch, G., Joller-Jemelka, H.I. et al. (1995) Cytokine production and visualised effects in the feto-maternal unit. Quantitative and topographic data on cytokines during intrauterine disease. Lab. Invest., 73, 384-392.
82. Stark, J.M. (1993) Pre-eclampsia and cytokine induced oxidative stress. Br. J. Obstet. Gynaecol., 100, 105-109.
83. Sutherland, A., Cooper, D.W., Howie, P.W. et al. (1981) The incidence of severe pre-eclampsia amongst mothers and mothers-in-law of pre-eclamptics and controls. Br. J. Obstet. Gynaecol., 88, 785-791.
84. Takakuwa, K., Arakawa, M., Tamura, M. et al. (1997) HLA antigens in patients with severe preeclampsia. J. Perinatal Med., 25, 79-83.
85. Thornton, J.G. and Onwude, J.L. (1991) Pre-eclampsia: discordance among identical twins. Br. Med. J., 303, 1241-1242.
86. Tuohy, J.F. and James, D.K. (1992) Pre-eclampsia and trisomy 13. Br. J. Obstet. Gynaecol., 99, 891-894.
87. Vince, G.S., Starkey, P.M., Austgulen, R. et al. (1995) Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br. J. Obstet. Gynaecol., 102, 20-25.
88. Visser, W., Beckmann, I., Bremer, H.A. et al. (1994) Bioactive tumour necrosis factor in pre-eclamptic patients with and without the HELLP syndrome. Br. J. Obstet. Gynaecol., 101, 1081-1082.
89. Wang, Y. and Walsh, S.W. (1996) TNF alpha concentrations and mRNA expression are increased in preeclamptic placentas. J. Reprod. Immunol., 32, 157-169.
90. H2 phenomenon? Immunol. Today, 14, 353-356.
91. Wilson, A.G., de Vries, N., Pociot, F. et al. (1993) An allelic polymorphism within the human tumour necrosis factor promoter region is strongly associated with HLA1, B8 and DR3 alleles. J. Exp. Med., 177, 557-560.
92. Wilton, A.N., Cooper, D.W., Brennecke, S.P. et al. (1990) Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DRB. Lancet, 336, 653-657.
93. Wilton, A.N., Barendse, W.J., Donald, J.A. et al. (1991) HLA-DRB types in pre-eclampsia and eclampsia. Tissue Antigens, 38, 137-141.
94. Wolde, S.T., Breedveld, F.C., de Vries, R.R.P. et al. (1993) Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis. Lancet, 341, 200-202.
95. Yasuda, M., Takakuwa, K., Tokunaga, A. and Tanaka, K. (1995) Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet. Gynecol., 86, 555-559.
96. Zweifel, P. (1916) Eklampie in handbuchder Geburtshilfe. Cited by MacGillivray (1983), see above.