Binding of hepatic lipase to heparin: Identification of specific heparin-binding residues in two distinct positive charge clusters

Journal of Lipid Research

Volumn 41, Issue 2, 2000, Pages 260-268

  Sendak, Rebecca A ^a   Berryman, Darlene E ^a   Gellman, Gabrielle ^a   Melford, Kristan ^a   Bensadoun, Andre ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Chinese hamster ovary cells; Heparin binding domains; Heparin sulfate proteoglycans; Heparin Sepharose chromatography; Hepatic lipase; Lipoprotein lipase

Indexed keywords

COMPLEMENTARY DNA; HEPARIN; LIPOPROTEIN LIPASE; LIVER TRIACYLGLYCEROL LIPASE; PROTEOGLYCAN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CHOLESTEROL TRANSPORT; CHROMATOGRAPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CHO CELLS; CRICETINAE; DNA PRIMERS; DNA, COMPLEMENTARY; HEPARIN; KINETICS; LIPASE; LIPOPROTEIN LIPASE; LIVER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033998074     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Olivecrona, G., and T Olivecrona. 1995. Triglyceride lipases and atherosclerosis. Curr. Opin. Lipidol. 6: 291-305.
2. Applebaum-Bowden, D. 1995. Lipases and lecithin: cholesterol acyltransferase in the control of lipoprotein metabolism. Curr. Opin. Lipidol. 6: 130-135.
3. Bensadoun, A. and D. E. Berryman. 1996. Genetics and molecular biology of hepatic lipase. Curr. Opin. Lipidol. 7: 77-81.
4. Sanan, D. A., J. Fan, A. Bensadoun, and J. M. Taylor. 1997. Hepatic lipase is abundant on both hepatocyte and endothelial cell sufaces in the liver. J. Lipid Res. 38: 1002-1013.
5. Santamarina-Fojo, S., C. Haudenschild, and M. Amar. 1998. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr. Opin. Lipidol. 9: 211-219.
6. Murase, T., and H. Itakura. 1981. Accumulation of intermediate density lipoprotein in plasma after intravenous administration of hepatic triglyceride lipase antibody in rats. Atherosclerosis. 39: 293-300.
7. Daggy, B. P., and A. Bensadoun. 1986. Enrichment apolipoprotein B-48 in the LDL density class following in vivo inhibition of hepatic lipase. Biochim. Biophys. Acta. 877: 252-261.
8. Goldberg, I. J., N. A. Le, J. R. Paterniti, Jr., H. N. Ginsberg, F. T. Lindgren, and W. V. Brown. 1982. Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in the cynomolgus monkey. J. Clin. Invest. 70: 1184-1192.
9. Brekenridge, W. C., J. A. Little, P. Alaupovic, C. S. Wang, A. Kuksis, G. Kakis, F. Lindgren, and G. Gardiner. 1982. Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase. Atherosclerosis. 45: 161-179.
10. Hegele, R. A., J. A. Little, C. Vezina, G. F. Maguire, L. Lu, T. S. Wolever, D. J. A. Jenkins, and P. W. Connelly. 1993. Hepatic lipase deficiency: clinical, biochemical and molecular genetic characteristics. Arterioscler. Thromb. 13: 720-728.
11. Homanics, G. E., H. V. de Silva, J. Osada, S. H. Zhang, H. Wong, J. Borensztajn, and N. Maeda. 1995. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J. Biol. Chem. 270: 2974-2980.
12. Qin, S., N. Bergeron, L. Kotite, R.M. Krauss, A. Bensadoun, and R. J. Havel. 1998. Metabolism of lipoproteins containing, apolipoprotein B in hepatic lipase-deficient mice. J. Lipid. Res. 39: 1661-1668.
13. Rothblat, G. H., F. H. Mahlberg, W. J. Jobnson, and M. C. Phillips. 1992. Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux. J. Lipid Res. 33: 1091-1097.
14. Ji, Z. S., H. L. Dichek, R. D. Miranda, and R. W. Mahley. 1997. Heparan sulfate proteoglycans participate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J. Biol. Chem. 272: 31285-31292.
15. Krapp, A., S. Ahle, S. Kersting, Y. Hua, K. Kneser, M. Nielsen, J. Gliemann, and U. Beisiegel. 1995. Hepatic lipase mediates the uptake of chylomicrons and β-VLDL into cells via the LDL receptor-related protein (LRP). J. Lipid Res. 37: 926-936.
16. Dichek, H. L., W. Brecht, J. Fan, Z. S. Ji, S. P. A. McCormick, H. Akeefe, L. Conzo, D. A. Sanan, K. H. Weisgraber, S. G. Young, J. M. Taylor, and R. W. Mahley. 1998. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J. Biol. Chem. 273: 1896-1903.
17. Ji, Z. S., S. Fazio, A. Bensadoun, J. M. Taylor, and R. W. Mahley. 1994. Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. J. Biol. Chem. 269:13429-13436.
18. Diard, P., M. I. Malewiak, D. Lagrange, and S. Griglio. 1994. Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes. Biochem. J. 299: 889-894.
19. Berryman, D. E., and A. Bensadoun. 1993. Site-directed mutagenesis of a putative heparin binding domain of avian lipoprotein lipase. J. Biol. Chem. 268: 3272-3276.
20. Hata, A., D. N. Ridinger, S. Sutherland, M. Emi, Z. Shuhua, R. L. Meyers, K. Ren, T. Cheng, I. Inoue, D. E. Wilson, P-H. Iverius, and J-M. Lalouel. 1993. Binding of lipoprotein lipase to heparin. Identification of five critical residues in two distinct segments of the amino terminal domain. J. Biol. Chem. 268: 8447-8457.
21. Ma, Y., H. L. Henderson, M-S. Liu, H. Zhang, I. J. Forsythe, I. Clark-Lewis, M. R. Hayden, and J. D. Brunzell. 1994. Mutagenesis in four candidate heparin-binding regions (residues 279-282, 291-304, 390-393, 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase. J. Lipid Res. 35: 2049-2059.
22. Sendak, R. A., and A. Bensadoun. 1998. Identification of a heparin-binding domain in the distal carboxyl-terminal region of lipoprotein lipase by site-directed mutagenesis. J. Lipid Res. 39: 1310-1315.
23. Davis, R. C., H. Wong, J. Nikazy, K. Wang, Q. Han, and M. C. Schotz. 1992. Chimeras of hepatic lipase and lipoprotein lipase. Domain localization of enzyme-specific properties. J. Biol. Chem. 267: 21499-21504.
24. Dichek, H. L., C. Parrot, R. Ronan, J. D. Brunzell, H. B. Brewer, and S. Santamarina-Fojo. 1993. Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase. J. Lipid Res. 34: 1393-1401.
25. Wong, H., R. C. Davis, J. Nikazy, K. E. Seebart, and M. C. Schotz. 1991. Domain exchange: characterisation of a chimeric lipase of hepatic lipase and lipoprotein lipase. Proc. Natl. Acad. Sci. USA. 88: 11290-11294.
26. Cardin, A. D., and H. J. R. Weintraub. 1989. Molecular modeling of protein-glycosaminoglycan interactions. Arteriosclerosis. 9: 21-32.
27. van Tilbeurgh, A. Roussel, J-M. Lalouel, and C. Cambillau. 1994. Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysis. J. Biol. Chem. 269: 4626-4633.
28. Berryman, D. E., J. J. Mulero, L. B. Hughes, D. L. Brasaemle, and A. Bensadoun. 1998. Oligomeric structure of hepatic lipase: evidence from a novel epitope tag technique. Biochem. Biophys. Acta. 1382:217-229.
29. Cheung, A. H., A. Bensadoun, and C-F. Cheng. 1979. Direct solid phase radioimmunoassay for chicken lipoprotein lipase. Anal. Biochem. 94: 346.
30. Hide, W. A., L. Chan, and W-H. Li. 1992. Structure and evolution of the lipase superfamily. J. Lipid Res. 33: 167-178.
31. Sensel, M. G., A. Legrand-Lorans, M-e. Wang, and A. Bensadoun. 1990. Isolation and characterization of clones for the rat hepatic lipase gene upstream regulatory region. Biochim. Biophys. Acta. 1048: 297-302.
32. Ho, S. N., H. D. Hunt, R. M. Horton, J. J. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene. 77: 51-59.
33. Cisar, L. A., A. J. Hoogewerf, M. Cupp, C. A. Rapport, and A. Bensadoun. 1989. Secretion and degradation of lipoprotein lipase in cultured adipocytes. J. Biol. Chem. 264: 1767-1774.
34. Cisar, L. A., and A. Bensadoun. 1985. Enzyme-linked immunosorbent assay for rat hepatic lipase. J. Lipid Res. 26: 380-386.
35. Cheng, C-F., A. Bensadoun, T. Bersot, J. S. T. Hsu, and K. H. Melford. 1985. Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase: reactivity with monoclonal antibodies to hepatic triglyceride lipase. J. Biol. Chem. 260: 10720-10727.
36. Labarca, C., and K. Paigen. 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102: 344-352.
37. Fromm, J. R., R. E. Hileman, E. E. O. Caldwell, J. M. Weiler, and R. J. Linhardt. 1997. Pattern and spacing of basic amino acids in heparin binding sites. Arch. Biochem. Biophys. 343: 92-100.
38. Berryman, D. E., and A. Bensadoun. 1995. Heparan sulfate proteoglycans and primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells. J. Chem. 270: 24525-24531.
39. Rojas, C., S. Knerbäck, and C. Hengtsson-Olivecrona. 1990. Synthesis and secretion of active lipoprotein lipase in Chinese-hamster ovary (CHO) cells. Biochem. J. 271: 11-15.
40. Schoonderwoerd, K., A. J. M. Verhoeven, and H. Jansen. 1994. Rat liver contains a limited number of binding sites for hepatic lipase. Biochem. J. 302:717-722.