Ototoxicity in children with malignant brain tumors treated with the "8 in 1" ChemOtherapy protocol

Medical and Pediatric Oncology

Volumn 27, Issue 1, 1996, Pages 26-31

  Ilveskoski, Ismo ^a   Saarinen, Ulla M ^a   Wiklund, Tom ^a   Perkkiö, Mikko ^b   Salmi, Toivo T ^c   Lanning, Marjatta ^d   Mäkipernaa, Anne ^e   Pihko, Helena ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF OULU   (Finland)

^e TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

"8 in 1" chemotherapy; Cisplatinum; Ototoxicity

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DACARBAZINE; HYDROXYUREA; LOMUSTINE; METHYLPREDNISOLONE; PROCARBAZINE; VINCRISTINE;

ADOLESCENT; ARTICLE; AUDIOGRAPHY; BRAIN TUMOR; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CHILD; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FINLAND; HEARING LOSS; HUMAN; INFANT; KIDNEY DISEASE; MALE; OTOTOXICITY; PRIORITY JOURNAL;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CHILD; CHILD, PRESCHOOL; CISPLATIN; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; CYTARABINE; DACARBAZINE; DRUG ADMINISTRATION SCHEDULE; EVALUATION STUDIES; FEMALE; FOLLOW-UP STUDIES; HEARING LOSS; HUMANS; HYDROXYUREA; INCIDENCE; INFANT; LOMUSTINE; MALE; METHYLPREDNISOLONE; PROCARBAZINE; RADIATION INJURIES; RISK FACTORS; VINCRISTINE;

EID: 0029975890     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-911X(199607)27:1<26::AID-MPO6>3.0.CO;2-W     Document Type: Article

References (15)

1. Evans E, Jenkin D, Sposto R, Ortega J, Wilson C, Wara W, Ertel I, Kramer S, Chang C, Leikin S, Hammond G: The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine and prednisone. J Neurosurg 92:572-582, 1990.
2. Sposto R, Ertel I, Jenkin R, Boesel C, Venes J, Ortega J, Evans A, Wara W, Hammond G: The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized mal. J Neurooncol 7:165-177, 1989.
3. Bleyer A, Millstein J, Balis F, Pendergrass T, Chard R, Hartmann J: Eight drugs in 1 day chemotherapy for brain tumors: a new approach and rationale for preradiation chemotherapy. Med Pediatr Oncol 11:213, 1983 (Abstr.)
4. Edwards M, Levin V, Wilson C: Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials. Cancer Treat Rep 64:1179-1205, 1980.
5. Goldie J: New thoughts on resistance to chemotherapy. Hosp Pract 18:165-177, 1983.
6. Hill B, Baserga R: The cell cycle and its significance for cancer treatment. Cancer Treat Rev 2:159-175, 1975.
7. Loehrer P. Einhorn L: Cisplatin. Diagnosis and treatment. Drugs five years later. Ann Int Med 100:704-713, 1984.
8. Kretschmar C, Warren M, Lavally B, Dyer S, Tarbell N: Ototoxicity of preradiation cisplatinum for children with central nervous system tumors. J Clin Oncol 8:1191-1198, 1990.
9. Schell M, McHaney V, Green A, Kun L, Hayes F, Horowitz M, Meyer W: Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation. J Clin Oncol 7:754-760, 1989.
10. McHaney V, Thibadoux G, Hayes F, Green A: Hearing loss in children receiving cisplatin chemotherapy. J Pediatr 102:314-317, 1983.
11. Pollera C, Marolla P, Nardi M, Ameglio F, Cozzo L, Bevere F: Very high-dose cisplatin-induced ototoxicity: a preliminary report on early and long-term effects. Cancer Chemother Pharmacol 21:61-64, 1988.
12. Ruiz L, Gilden J, Jaffe N, Robertson R, Wang Y: Auditory function in pediatric osteosarcoma patients treated wtih multiple doses of cis-diamminedichloroplatinum. Cancer Res 49:742-744, 1989.
13. Schaefer S, Post J, Close L, Wright C: Ototoxicity of low- and moderate-dose cisplatin. Cancer 56:1934-1939, 1985.
14. Ilveskoski I, Saarinen U, Perkkiö M, Salmi T, Lanning M, Mäkipernaa A, Sankila R, Pihko H: Chemotherapy with the "8 in 1" protocol for malignant brain tumors in children: a populationbased study in Finland. Pediatr Hematol Oncol (in press).
15. Walker D, Pillow J, Waters K, Keir E: Enhanced cis-platinum ototoxicity in children with brain tumours who have received simultaneous or prior cranial irradiation. Med Pediatr Oncol 17: 48-52, 1989