Late onset of CAD gene amplification in unamplified PALA resistant Chinese hamster mutants

Cancer Letters

Volumn 150, Issue 2, 2000, Pages 119-127

  Mucciolo, Elena ^a   Bertoni, Livia ^a   Mondello, Chiara ^b   Giulotto, Elena ^a  

^a Univesita degli Studi di Pavia   (Italy)

^b Ist Genet Biochim ed E   (Italy)

Author keywords

Chinese hamster cells; Gene amplification; N phosphonacetyl L asparate resistance

Indexed keywords

PLASMID DNA; SPARFOSIC ACID;

ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CELL GROWTH; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HAMSTER; MITOSIS; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CHO CELLS; CRICETINAE; DIHYDROOROTASE; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; GENE DOSAGE; MULTIENZYME COMPLEXES; MUTATION; PHOSPHONOACETIC ACID;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; RODENTIA;

EID: 0033993605     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00289-X     Document Type: Article

References (38)

1. Swyryd E.A., Seaver S.S., Stark G.R. N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture. J. Biol. Chem. 249:1974;6945-6950.
2. Ardalan B., Sridhar K.S., Bendetto P., Richman S., Waldman S., Morrell L., Feun L., Savaraj N., Fodor M., Livingstone A.A. Phase I, II study of high-dose leucovorin with low dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies. Cancer. 68:1991;1242-1246.
3. Casper E.S., Baselga J., Smart T.B., Magill G.B., Markman M., Ranhosky A. A phase II trial of PALA plus dipyridamole in patients with advanced malignancies. Cancer Chemother. Pharmacol. 28:1991;51-54.
4. Morrell L.M., Bach A., Richman S.P., Goodman P., Fleming T.R., Mac-Donald J.S. A phase II multi-institutional trial of low-dose N-(phosphonacetyl)-L-aspartate and high-dose 5-fluorouracil as short term infusion in the treatment of adenocarcinoma of the pancreas. A South-west Oncology Group study. Cancer. 67:1991;363-366.
5. Johnson R.K., Inouye T., Goldin A., Stark G.R. Antitumour activity of N-(phosphonacetyl)-L-aspartic acid, a transition state inhibitor of aspartate transcarbamylase. Cancer Res. 36:1976;2720-2725.
6. Johnson R.K. Reversal of toxicity and antitumor activity of N-(phosphonacetyl)-L-aspartate by uridine or carbamyl-DL-aspartate in vivo. Biochem. Pharmacol. 26:1977;81-84.
7. Stark G.R., Wahl G.M. Gene amplification. Annu. Rev. Biochem. 53:1984;447-491.
8. Federspiel N.A., Beverley S.M., Schilling J.M., Schimke R.T. Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification. J. Biol. Chem. 259:1984;9127-9140.
9. Debatisse M., Saito I., Buttin G., Stark G.R. Preferential amplification of rearranged sequences near amplified adenylate deaminase genes. Mol. Cell Biol. 8:1988;17-24.
10. Windle B.E., Wahl G.M. Molecular dissection of mammalian gene amplification: New mechanistic insights revealed by analysis of very early events. Mutation Res. 276:1992;199-224.
11. Stark G.R. Regulation and mechanisms of mammalian gene amplification. Adv. Cancer Res. 61:1993;87-113.
12. Trask B.J., Hamlin J.L. Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus. Genes Dev. 3:1989;1913-1925.
13. Smith K.A., Gorman P.A., Stark M.B., Groves R.P., Stark G.R. Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells. Cell. 63:1990;1219-1227.
14. Toledo F., Le Roscouet D., Buttin G., Debatisse M. Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. EMBO J. 11:1992;2665-2673.
15. Toledo F., Buttin G., Debatisse M. The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells. Curr. Biol. 3:1993;255-264.
16. Ma C., Martin S., Trask B., Hamlin J.L. Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells. Genes Dev. 7:1993;605-620.
17. Smith K.A., Stark M.B., Gorman P.A., Stark G.R. Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells. Proc. Natl. Acad. Sci. USA. 89:1992;5427-5431.
18. Bertoni L., Attolini C., Tessera L., Mucciolo E., Giulotto E. Telomeric and non-telomeric (TTAGGG)n sequences in gene amplification and chromosome stability. Genomics. 24:1994;53-62.
19. White A.E., Livanos E.M., Tlsty T.D. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev. 8:1994;666-667.
20. Schaefer D.I., Livanos E.M., White A.E., Tlsty T.D. Multiple mechanisms of N-(phosphonacetyl)-L-aspartate drug resistance in SV-40-infected precrisis human fibroblasts. Cancer Res. 53:1993;4946-4951.
21. Sharma R.C., Schimke R.T. The propensity for gene amplification: a comparison of protocols, cell lines, and selection agents. Mutation Res. 304:1994;243-260.
22. Smith K.A., Chernova O.B., Groves R.P., Stark M.B., Martinez J.L., Davidson J.N., Trent J.M., Patterson T.E., Agarwal A., Duncan P., Agarwal M.L., Stark G.R. Multiple mechanisms of N-(phosphonacetyl)-L-aspartate resistance in human cell lines: Carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged. Proc. Natl. Acad. Sci. USA. 94:1997;1816-1821.
23. Bertoni L., Attolini C., Simi S., Giulotto E. Localization of the Chinese hamster CAD gene reveals homology between human chromosome 2p and Chinese hamster 7q. Genomics. 16:1993;779-781.
24. Zieg J., Clayton C.E., Ardeshir F., Giulotto E., Swyryd E.A., Stark G.R. Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol. Cell Biol. 3:1983;2089-2098.
25. Tessera L., Mucciolo E., Bertoni L., Giulotto E. Selection of N-(phosphonacetyl)-L-aspartate resistant Chinese hamster mutants in the presence of the uridine uptake inhibitor dipyridamole. Anticancer Res. 15:1995;189-192.
26. Shigesada K., Stark G.R., Maley J.A., Niswander L.A., Davidson J.N. Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase. Mol. Cell Biol. 5:1985;1735-1742.
27. Riordan J.R., Deuchars K., Kartner N., Alon N., Trent J., Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature. 316:1985;817-819.
28. Giulotto E., Saito I., Stark G.R. Structure of the DNA formed in the first step of CAD gene amplification. EMBO J. 5:1986;2115-2121.
29. Skoog L. An Enzymatic Method for the Determination of dCTP and dGTP in Picomole Amounts. Eur. J. Biochem. 17:1970;202-208.
30. Ottaggio L., Agnese C., Bonatti S., Cavolina P., De Ambrosis A., Degan P., Di Leonardo A., Miele M., Randazzo R., Abbondandolo A. Chromosome aberrations associated with CAD gene amplification in Chinese hamster cultured cells. Mutation Res. 199:1988;111-121.
31. Giulotto E., Knights C., Stark G.R. Hamster cells with increased rates of DNA amplification, a new phenotype. Cell. 48:1987;837-845.
32. Biedler J.L., Chang T., Scotto K.W., Melera P.W., Spengler B.A. Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells. Cancer Res. 48:1988;3179-3187.
33. Hahn P., Nevaldine B., Morgan W.F. X-ray induction of metotrexate resistance due to dhfr gene amplification. Somat. Cell Mol. Genet. 16:1990;413-423.
34. Windle B., Draper B.W., Yin Y., O'Gorman S., Wahl G.M. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 5:1991;160-174.
35. Poupon M.F., Smith K.A., Chernova O.B., Gilbert C., Stark G.R. Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles. Mol. Biol. Cell. 7:1996;345-354.
36. Coquelle A., Pipiras E., Toledo F., Buttin G., Debatisse M. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell. 89:1997;215-225.
37. Reichard P. Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev. Biochem. 57:1988;349-374.
38. Brison O. Gene amplification and tumor progression. Biochem. Biophys. Acta. 1155:1993;25-41.