Heart muscle-specific gene expression using replication defective recombinant adenovirus

Gene Therapy

Volumn 3, Issue 10, 1996, Pages 919-926

  Rothmann, T ^a,b   Katus, H A ^a   Hartong, R ^a   Perricaudet, M ^c   Franz, W M ^a,b,d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Adenovirus; Gene expression; Heart muscle; Myosin light chain 2v promoter

Indexed keywords

LUCIFERASE; MYOSIN LIGHT CHAIN; VIRUS DNA;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HEART MUSCLE CELL; MYOCARDIAL DISEASE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RAT; ROUS SARCOMA ONCOVIRUS; THIGH; TISSUE SPECIFICITY; VIRUS RECOMBINANT; VIRUS REPLICATION;

ADENOVIRUSES, HUMAN; ANIMALS; CELL LINE; CELLS, CULTURED; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; HELA CELLS; HUMANS; LUCIFERASES; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINATION, GENETIC; THIGH; TRANSGENES; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES; ONCOVIRINAE; RICE STRIPE VIRUS; ROUS SARCOMA VIRUS;

EID: 0029977935     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Perloff JK. Congenital heart disease in adults. In: Braunwald E (ed). Heart Disease. Saunders: Philadelphia, 1992, pp 1810-1826.
2. Towbin JA et al. X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. Circulation 1993; 87: 1854-1865.
3. Franz WM et al. X-linked dilated cardiomyopathy: novel mutation of the dystrophin gene. Ann N Y Acad Sci 1995; 752: 470-491.
4. Kass-Eisler A et al. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA 1993; 90: 11498-11502.
5. Guzman RJ et al. Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res 1992; 73: 1202-1207.
6. Barr E et al. Efficient catheter-mediated gene transfer into the heart using replication defective adenovirus. Gene Therapy 1994; 1: 51-58.
7. Kirshenbaum LA et al. Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus. J Clin Invest 1993; 92. 381-387.
8. Chanock RM et al. Immunization by selective infection with type 4 adenovirus in human diploid tissue cultures. I. Safety and lack of oncogenicity and tests for potency in volunteers. J Am Med Assoc 1966; 195: 445-452.
9. Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenovirus for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
10. Krougliak V, Graham FL. Development of cell lines capable of complementing E1, E4 and protein IX defective adenovirus type 5 mutants. Hum Gene Ther 1995; 6: 1575-1586.
11. Wang Q, Jia XC, Finer, MH. A packaging cell line for propagation of recombinant adenovirus containing two lethal generegion deletions. Gene Therapy 1995; 2: 775-783.
12. Yeh P et al. Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J Virol 1996; 70: 559-565.
13. Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2a in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 6196-6200.
14. Yang Y et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994; 7: 362-369.
15. Stradtford-Perricaudet LD, Makeh I, Perricaudet M, Briand P. Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992; 90: 626-630.
16. Huard J et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Therapy 1995; 2: 107-115.
17. Kass-Eisler A et al The impact of developmental stage, route of administration and the immune system on adenovirus mediated gene transfer. Gene Therapy 1994; 1. 395-402.
18. Franz WM et al. Heart-specific targeting of firefly luciferase by the myosin light chain-2 promoter and developmental regulation in transgenic mice. Circ Res 1993; 73: 629-638.
19. Lee KJ et al. Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene. J Biol Chem 1992; 267: 15875-15885.
20. Lee JL, Hickey R, Zhu H, Chien KR. Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice Mol Cell Biol 1994; 14: 1220-1229
21. Zou Y, Chien KR. EFI √YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene. Mol Cell Biol 1995; 15: 2972-2982.
22. Yu Y-T et al. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Den 1992; 6: 1783-1798.
23. Zhu H et al. A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) within the rat myosin light chain-2 gene. Mol Cell Biol 1993; 13: 4432-4444.
24. Zhu H et al. A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells. Mol Cell Biol 1991; 11: 2273-2281
25. Overbeek PA, Lai SP, Van Quill KR, Westphal H. Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal repeats. Science 1986; 231: 1574-1577.
26. Graham FL, Smiley J, Russel WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 1977; 36: 59-74.
27. Wet JR et al. Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 1987; 7: 725-737.
28. Hearing P, Shenk T. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element. Cell 1983; 33: 695-703.
29. Hearing P, Samulski RJ, Wishart WL, Shenk T. Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome. J Virol 1987; 61: 2555-2558
30. Henderson SA et al. Structure, organization and expression of the rat cardiac myosin light chain-2 gene. J Biol Chem 1989; 264: 1842-1848.
31. Acsadi G et al. A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity. Hum Mol Gen 1994; 3: 579-584.
32. Ragot T et al Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature 1993; 361: 647-650.
33. Vincent N et al. Long-term correction of mouse dystrophic degeneration by adenovirus-mediated transfer of a minidystrophin gene. Nat Genet 1993, 5: 130-134.
34. Quantin B, Perricaudet LD, Tajbakhsh S, Mandel JL. Adenovirus as an expression vector in muscle cells in vivo. Proc Natl Acad Sci USA 1992; 89: 2581-2584.
35. Bessereau JL et al. In vivo and in vitro analysis of electrical activity-dependent expression of muscle acetylcholine receptor genes using adenovirus. Proc Natl Acad Sci USA 1994; 91: 1304-1308.
36. Jin Y et al. Effect of enhancer sequences on ventricular myosin light chain-2 promoter activity in heart muscle and nonmuscle cells. Biochem Biophys Res Commun 1995; 210: 260-266.
37. Johns DC et al. Adenovirus-mediated expression of a voltage-gated potassium channel in vitro (rat cardiac myocytes) and in vivo (rat liver). J Clin Invest 1995; 96: 1152-1158.
38. Zhang WW, Koch PE, Roth JA. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. BioTechniques 1995; 18: 444-447.
39. Sen A et al. Terminally differentiated neonatal rat myocardial cells proliferate and maintain specific differentiated functions following expression of SV40 large T antigen. J Biol Chem 1988; 263: 19132-19136.
40. Ausbel FM et al. Current Protocols in Molecular Biology Greene and Wiley: New York, 1989.
41. Gossler A, Zachgo J. Gene and enhancer trap screens in ES cell chimeras. In: Joyner AL (ed). Gene Targeting. Oxford University Press, Oxford, 1993, pp 181-225.