Cytokines in genetic susceptibility to multiple sclerosis: A candidate gene approach

Journal of Neuroimmunology

Volumn 102, Issue 1, 2000, Pages 107-112

  Reboul, Jocelyne ^a   Mertens, Caroline ^a   Levillayer, Florence ^b   Eichenbaum Voline, Sophie ^c   Vilkoren, Thomas ^b   Cournu, Isabelle ^a   Babron, Marie Claude ^c   Lyon Caen, Olivier ^a   Clerget Darpoux, Françoise ^c   Edan, Gilles ^d   Clanet, Michel ^e   Brahic, Michel ^b   Bureau, Jean François ^b   Fontaine, Bertrand ^a   Liblau, Roland ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

^d PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^e CHU PURPAN   (France)

Author keywords

Autoimmunity; Cytokines; Genetics; Multiple sclerosis

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ANTIBODY;

ALLELE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FAMILY; FEMALE; GENE LOCUS; GENETIC ANALYSIS; GENETIC MARKER; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN EXPERIMENT; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NORMAL HUMAN; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

CYTOKINES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ANTIGENS; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MALE; MULTIPLE SCLEROSIS; RECEPTORS, INTERLEUKIN-2;

EID: 0033992193     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00158-7     Document Type: Article

References (38)

1. Brassat, D., Azais-Vuillemein, C., Yaouang, J., Semana, G., Reboul, J., Cournu, I., Mertens, C., Edan, G., Lyon-Caen, O., Clanet, M., Fontaine, B., the French Multiple Sclerosis Genetics Group, 1999. Familial factors influence disability in MS multiplex families. Neurology.
2. Brewsler E.S., Brennan M.B., Vissing H. Dinucleotide repeat polymorphism in the IL-2Rβ gene. Nucleic Acid Research. 19:1991;14.
3. Bureau J.F., Montagutelli X., Bihl F., Lefebvre S., Guenet J.L., Brahic M. Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system. Nature Genetics. 5:1993;87-91.
4. Bureau J.F., Bihl F., Brahic M., Le Paslier D. The gene coding for interferon-γ is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene. Genomic. 28:1995;109-112.
5. Butterfield R.J., Sudweeks J.D., Blankenhorn E.P., Korngold R., Marini J.C., Todd J.A., Roper R.J., Teuscher C. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J. Immunol. 161:1998;1860-1867.
6. Chataway J., Feakes R., Coraddu F., Gray J., Deans J., Fraser M., Robertson N., Broadley S., Jones H., Clayton D., Goodfellow P., Sawcer S., Compston A. The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen. Brain. 121:1998;1869-1887.
7. Davies J.L., Kawaguchi Y., Bennett S.T., Copeman J.B., Cordell H.J., Pritchard L.E., Reed P.W., Gough S.C.L., Jenkins S.C., Palmer S.M., Balfour K.M., Rowe B.R., Farrall M., Barnett A.H., Bain S.C., Todd J.A. A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 371:1994;130-136.
8. Ebers G.C., Sadovnick A.D. The role of genetic factors in multiple sclerosis susceptibility. J. Neuroimmunol. 54:1994;1-17.
9. Ebers G.C., Kukay K., Bulman D.E., Sadovnick A.D., Rice G., Anderson C., Armstrong H., Cousin C., Bell R.B., Hader W., Paty D.W., Hashimoto S., Oger J., Duquette P., Warren S., Gray T., O'Connor P., Nath A., Auty A., Metz L., Francis G., Paulset J.E., Murray T.J., Pryse-Phillips W., Nelson R., Freedman M., Brunet D., Bouchard J.P., Hinds D., Risch N., Peppler R., Peppler R. A full genome search in multiple sclerosis. Nature Genetics. 13:1996;472-476.
10. Encinas J.A., Lees M.B., Sobel R.A., Symonowicz C., Greer J.M., Shovlin C.L., Weiner H.L., Seidman C.E., Seidman J.G., Kuchroo V.K. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J. Immunol. 157:1996;2186-2192.
11. Encinas J.A., Wicker L.S., Peterson L.B., Mukasa A., Teuscher C., Sobel R., Weiner H.L., Seidman C.E., Seidman J.G., Kuchroo V.K. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing IL2. Nature Genetics. 21:1999;158-160.
12. Epplen C., Jäckel S., Santos E.J., D'Souza M., Poehlau D., Dotzauer B., Sindern E., Haupts M., Rüde K.P., Weber F., Stöver J., Poser S., Gehler W., Malin J.P., Przuntek H., Epplen J.T. Genetic predisposition to multiple sclerosis as revealed by immunoprinting. Ann. Neurol. 41:1997;341-352.
13. Goodkin D.E., Doolittle T.H., Hauser S.S., Ransohoff R.M., Roses A.D., Rudick R.A. Diagnostic criteria for multiple sclerosis research involving multiply affected families. Arch. Neurol. 48:1991;805-807.
14. Gorham J.D., Güler M.L., Steen R.G., Mackey A.J., Daly M.J., Frederick K., Dietrich W.F., Murphy K.M. Genetic mapping of a murine locus controlling development of T helper 1/helper 2 type responses. Proc. Natl. Acad. Sci. U.S.A. 93:1996;12467-12472.
15. He B., Xu C., Yang B., Landtblom A.M., Fredrikson S., Hillert J. Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis. J. Neuroimmunol. 86:1998;13-19.
16. Kruglyak L., Lander E.S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57:1995;439-454.
17. Kuokkanen S., Gschwend M., Rioux J.D., Daly M.J., Terwilliger J.D., Tienari P.J., Wikström J., Palo J., Stein L.D., Hudson T.J., Lander E.S., Peltonen L. Genomewide scan of multiple sclerosis in Finnish multiplex families. Am. J. Hum. Genet. 61:1997;1379-1387.
18. Laman J.D., Thompson E.J., Kappos L. Balancing the Th1/Th2 concept in multiple sclerosis. Immunol. Today. 19:1998;489-490.
19. Lander E., Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics. 11:1995;241-247.
20. Lucchinetti C.F., Brück W., Rodriguez M., Lassmann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol. 6:1996;259-274.
21. Martin R., Ruddle N.H., Reingold S., Hafler D.A. T helper cell differentiation in multiple sclerosis and autoimmunity. Immunol. Today. 19:1998;495-498.
22. Mertens C., Brassat D., Reboul J., Eichenbaum-Voline S., Vuillemein-Azais C., Cournu I., Babron M.C., Semana G., Edan G., Clanet M., Clerget-Darpoux F., Baron Van Evercooren A., Lyon-Caen O., Liblau R., Fontaine B. A systematic study of oligodendrocyte growth factors as candidates for genetic susceptibility to MS. Neurology. 51:1998;748-753.
23. Olsson T. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:1995;245-268.
24. Panitch H.S., Hirsch R.L., Haley A.S., Johnson K.P. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1:1987;893-894.
25. Paty, D.W., Ebers, G.C., 1988. Multiple sclerosis. Contemporary neurology series 50. FA Davis, Philadelphia.
26. Rep M.H.G., Schrijver H.M., van Lopik T., Hintzen R.Q., Roos M.T.L., Ader H.J., Polman C.H., van Lier R.A.W. Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients. J. Neuroimmunol. 96:1999;92-100.
27. Risch N. Linkage strategies for genetically complex traits: III. The effect of marker polymorphism on analysis of affected relative pairs. Am. J. Hum. Genet. 52:1990;362-374.
28. Rudick R.A., Ransohoff R., Lee J.C., Peppler R., Yu M., Mathisen P.M., Tuohy V. In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis. Neurology. 50:1998;1294-1300.
29. Ruiz Linares A. Dinucleotide repeat polymorphism in the interferon-gamma (IFNG) gene. Hum. Mol. Genet. 2:1993;1508.
30. Sawcer S., Jones H.B., Feakes R., Gray J., Smaldon N., Chataway J., Robertson N., Clayton D., Goodfellow P.N., Compston A. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genetics. 13:1996;464-468.
31. Smith D.R., Balashov K.E., Hafler D.A., Khoury S.J., Weiner H.L. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann. Neurol. 42:1997;313-318.
32. Spielman R.S., McGinnis R.E., Ewens W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus. Am. J. Hum. Genet. 52:1993;506-516.
33. Sundvall M., Jirholt J., Yang H.T., Jansson L., Engström A., Pettersson U., Holmdahl R. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nature Genetics. 10:1995;313-317.
34. Teuscher C., Rhein D.M., Livingstone K.D., Paynter R.A., Doerge R.W., Nicholson S.M., Melvold R.W. Evidence that Tmevd2 and eae3 may represent either a common locus or members of a gene complex controlling susceptibility to immunologically mediated demyelination in mice. J. Immunol. 159:1997;4930-4934.
35. The Multiple Sclerosis Genetics Group A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nature Genetics. 13:1996;469-471.
36. Voskhul R.R., Goldstein A.M., Simonis T., Davey R., McFarland H.F. DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families. Ann. Neurol. 39:1996;804-807.
37. Walter M.A., Spillett D.J., Thomas P., Weissenbach J., Goodfellow P.N. A method for constructing radiation hybrid maps of whole genomes. Nature Genetics. 7:1994;22-28.
38. The French Multiple Sclerosis Genetics Group, Yaouanq J., Semana G., Eichenbaum S., Quelvennec E., Roth M.P., Clanet M., Edan G., Clerget-Darpoux F. Evidence for linkage disequilibrium between HLA-DRB1 gene and multiple sclerosis. Science. 276:1997;664-665.