Evidence for a causative role of N-methyl-D-aspartate receptors in an in vitro model of alcohol withdrawal hyperexcitability

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 1, 1998, Pages 87-97

  Thomas, Mark P ^a,b   Monaghan, Daniel T ^a,b   Morrisett, Richard A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ABSTINENCE; ALCOHOL WITHDRAWAL; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; DRUG EFFECT; ELECTROPHYSIOLOGY; EXCITABILITY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SYNAPTIC TRANSMISSION;

ANIMALS; ETHANOL; FEMALE; HIPPOCAMPUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SUBSTANCE WITHDRAWAL SYNDROME; SYNAPSES;

EID: 0032463605     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Bahr BA (1995) Long-term hippocampal slices: A model system for investigating synaptic mechanisms and pathological processes. J Neurosci Res 42:294-305.
2. Blevins T, Mirshahi T and Woodward JJ (1995) Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons after chronic ethanol exposure. Neurosci Lett 200:214-218.
3. Buchs PA, Stoppini L and Muller D (1993) Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures. Brain Res Dev Brain Res 71:81-91.
4. Chandler LJ, Newsom H, Sumners C and Crews F (1993) Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. J Neurochem 60: 1578-1581.
5. Follesa P and Ticku MK (1996) Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J Biol Chem 271:13297-13299.
6. Gähwiler BH (1981) Organotypic monolayer cultures of nervous tissue. J Neurosci Methods 4:329-342.
7. Grant KA, Valverius P, Hudspith M and Tabakoff B (1990) Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol 176:289-296.
8. Hestrin S, Nicoll RA, Perkel DJ and Sah P (1990) Analysis of excitatory synaptic action in pyramidal cells using whole-cell recording from rat hippocampal slices. J Physiol Lond 422:203-225.
9. Hoffman PL, Rabe CS, Moses F and Tabakoff B (1989) N-methyl-D-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production. J Neurochem 52:1937-1940.
10. Hu XJ, Follesa P and Ticku MK (1996) Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Brain Res Mol Brain Res 36:211-218.
11. Iorio KR, Reinlib L, Tabakoff B and Hoffman PL (1992) Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Mol Pharmacol 41:1142-1148.
12. Lehmann J, Hutchison AJ, McPherson SE, Mondadori C, Schmutz M, Sinton CM, Tsai C, Murphy DE, Steel DJ, Williams M, Cheney DL and Wood PL (1988) CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J Pharmacol Exp Ther 246:65-75.
13. Liljequist S (1991) The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizures. Eur J Pharmacol 192:197-198.
14. Lovinger DM (1995) Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: Relation to the actions of ifenprodil. J Pharmacol Exp Ther 274:164-172.
15. Lovinger DM, White G and Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724.
16. Lovinger DM, White G and Weight FF (1990) NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci 10:1372-1379.
17. McBain CJ, Boden P and Hill RG (1989) Rat hippocampal slices 'in vitro' display spontaneous epileptiform activity after long-term organotypic culture. J Neurosci Methods 27:35-49.
18. McBain CJ and Mayer ML (1994) N-Methyl-D-aspartic acid receptor structure and function. Physiol Rev 74:723-760.
19. McCown TJ, Duncan GE, Johnson KB and Breese GR (1995) Metabolic and functional mapping of the neural network subserving inferior collicular seizure generalization. Brain Res 701:117-128.
20. Molleman A and Little HJ (1995) Increases in non-N-methyl-D-aspartate glutamatergic transmission, but no change in gamma-aminobutyric acidB transmission, in CA1 neurons during withdrawal from in vivo chronic ethanol treatment. J Pharmacol Exp Ther 274:1035-1041.
21. Monyer H, Burnashev N, Laurie DJ, Sakmann B and Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540.
22. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B and Seeburg PH (1992) Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science 256:1217-1221.
23. Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N and Nakanishi S (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354:31-37.
24. Morrisett RA, Martin D, Oetting TA, Lewis DV, Wilson WA and Swartzwelder HS (1991) Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner. Neuropharmacology 30:1173-1178.
25. Morrisett RA, Rezvani AH, Overstreet D, Janowsky DS, Wilson WA and Swartzwelder HS (1990) MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol 176:103-105.
26. Morrisett RA and Swartzwelder HS (1993) Attenuation of hippocampal long-term potentiation by ethanol: A patch-clamp analysis of glutamatergic and GABAergic mechanisms. J Neurosci 13:2264-2272.
27. Muller D, Buchs PA and Stoppini L (1993) Time course of synaptic development in hippocampal organotypic cultures. Brain Res Dev Brain Res 71:93-100.
28. Randall AD, Schofield JG and Collingridge GL (1990) Whole-cell patch-clamp recordings of an NMDA receptor-mediated synaptic current in rat hippocampal slices. Neurosci Lett 114:191-196.
29. Ripley TL and Little HJ (1995) Ethanol withdrawal hyperexcitability in vitro is selectively decreased by a competitive NMDA receptor antagonist. Brain Res 699:1-11.
30. Sheng M, Cummings J, Roldan LA, Jan YN and Jan LY (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368:144-147.
31. Stoppini L, Buchs PA and Muller D (1991) A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37:173-182.
32. Swartzwelder HS, Wilson WA and Tayyeb MI (1995) Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:320-323.
33. Tabakoff B and Rothstein JD (1983) Biology of tolerance and dependence. In Medical and Social Aspects of Alcohol Abuse (Tabakoff B, Sutker PB and Randall CL, eds), pp 187-220, New York, Plenum Press.
34. Thomas MP, Larson HC, Monaghan DT and Morrisett RA (1995) The hippocampal explant slice culture as a model system for analysis of ethanol effects on NMDA synaptic currents. Research Society on Alcoholism, Steamboat Springs, CO, June 18.
35. Thomas MP, Webster WW, Monaghan DT and Morrisett RA (1996) Electrographic seizures and NMDAR-mediated synaptic responses in hippocampal explants after chronic ethanol exposure. Research Society on Alcoholism, Washington, DC, June 24.
36. Thomas MP and Morrisett RA (1997) Neuronal viability and NMDA-induced neurotoxicity after ethanol exposure and withdrawal in hippocampal explants. Research Society on Alcoholism, San Francisco, CA, July 22.
37. Trevisan L, Fitzgerald LW, Brose N, Gasic GP, Heinemann SF, Duman RS and Nestler EJ (1994) Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J Neurochem 62:1635-1638.
38. Victor M and Brausch C (1967) The role of abstinence in the genesis of alcoholic epilepsy. Epilepsia 8:1-20.
39. Watanabe M, Inoue Y, Sakimura K and Mishina M (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3:1138-1140.
40. Wenzel A, Fritschy JM, Mohler H and Benke D (1997) NMDA receptor heterogeneity during postnatal development of the rat brain: Differential expression of the NR2A, NR2B and NR2C subunit proteins. J Neurochem 68:469-478.
41. Whittington MA, Lambert JD and Little HJ (1995) Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability. Alcohol Alcohol 30:105-114.