Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2

Molecular and Cellular Biology

Volumn 20, Issue 4, 2000, Pages 1419-1425

  Kume, Tsutomu ^a   Deng, Keyu ^a   Hogan, Brigid L M ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; HOMOZYGOSITY; KIDNEY DEVELOPMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FERTILITY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HOMOZYGOTE; KIDNEY; LAC OPERON; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PHENOTYPE; URETER;

EID: 0033985592     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.4.1419-1425.2000     Document Type: Article

References (45)

1. Ang, S. L., and J. Rossant. 1994. HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78:561-574.
2. Ang, S. L., A. Wierda, D. Wong, K. A. Stevens, S. Cascio, J. Rossant, and K. S. Zaret. 1993. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119:1301-1315.
3. Bi, W., J. M. Drag, Z. Zhang, R. R. Behringer, and B. de Crombrugghe. 1999. Sox9 is required for cartilage formation. Nat. Genet. 22:85-89.
4. Chen, J., H. J. Knowles, J. L. Hebert, and B. P. Hackett. 1998. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Investig. 102: 1077-1082.
5. Davies, J. A., and J. B. Bard. 1998. The development of the kidney. Curr. Top. Dev. Biol. 39:245-301.
6. Dou, C., X. Ye, C. Stewart, E. Lai, and S. C. Li. 1997. TWH regulates the development of subsets of spinal cord neurons. Neuron 18:539-551.
7. Dressler, G. R. 1999. Kidney development branches out. Dev. Genet. 24: 189-193.
8. Dressier, G. R., U. Deutsch, K. Chowdhury, H. O. Nornes, and P. Gruss. 1990. Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 109:787-795.
9. Dudley, A. T., R. E. Godin, and E. J. Robertson. 1999. Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme. Genes Dev. 13:1601-1613.
10. Dudley, A. T., K. M. Lyons, and E. J. Robertson. 1995. A requirement for bone morphogenetic prolein-7 during development of the mammalian kidney and eye. Genes Dev. 9:2795-2807.
11. Dunn, N. R., G. E. Winnier, L. K. Hargett, J. J. Schrick, A. B. Fogo, and B. L. M. Hogan. 1997. Haploin sufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 188: 235-247.
12. Ernstsson, S., R. Betz, S. Lagercrantz, C. Larsson, S. Ericksson, A. Cederberg, P. Carlsson, and Enerback. 1997. 1997. Cloning and characterization of freac-9 (FKHL171), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34. Genomics 46:78-85.
13. Ernstsson, S., S. Pierrou, M. Hulander, A. Cederberg, M. Hellqvist, P. Carlsson, and S. Enerback. 1996. Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53. J. Biol. Chem. 271:21094-21099.
14. Green, M. C. 1968. Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouse. J. Exp. Zool. 167:129-150.
15. Gruneberg, H. 1943. Congenital hydrocephalus in the mouse: a case of spurious pleiotropism. J. Genet. 45:1-21.
16. Hatini, V., S. O. Huh, D. Herzlinger, V. C. Soares, and E. Lai. 1996. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged helix transcription factor BF-2. Genes Dev. 10:1467-1478.
17. Hiemisch, H., A. P. Monaghan, G. Schutz, and K. H. Kaestner. 1998. Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives. Mech. Dev. 73:129-132.
18. Hong, H. K., J. H. Lass, and A. Chakravarti. 1999. Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcription factor gene. Hum. Mol. Genet. 8:625-637.
19. Iida, K., H. Koseki, H. Kakinuma, N. Kato, Y. Mizutani-Koseki, H. Ohuchi, H. Yoshioka, S. Noji, K. Kawamura, Y. Kataoka, F. Ueno, M. Taniguchi, N. Yoshida, T. Sugiyama, and N. Miura. 1997. Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124:4627-4638.
20. Kaestner, K. H., S. C. Bleckmann, A. P. Monaghan, J. Schlondorff, A. Mincheva, P. Lichter, and G. Schutz. 1996. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development 122:1751-1758.
21. Kaestner, K. H., G. Schutz, and A. P. Monaghan. 1996. Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system. Mech. Dev. 55:221-230.
22. Kaestner, K. H., D. G. Silberg, P. G. Traber, and G. Schutz. 1997. The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev. 11: 1583-1595.
23. Kaufmann, E., and W. Knochel. 1996. Five years on the wings of fork head. Mech. Dev. 57:3-20.
24. Kidson, S. H., T. Kume, K. Deng, V. Winfrey, and B. L. M. Hogan. 1999. The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev. Biol. 211:306-322.
25. Kume, T., K. Y. Deng, V. Winfrey, D. B. Gould, M. A. Walter, and B. L. M. Hogan. 1998. The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell 93:985-996.
26. Labosky, P. A., G. E. Winnier, T. L. Jetton, L. Hargett, A. K. Ryan, M. G. Rosenfeld, A. F. Parlow, and B. L. M. Hogan. 1997. The winged helix gene. Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development 124:1263-1274.
27. Lechner, M. S., and G. R. Dressier. 1997. The molecular basis of embryonic kidney development. Mech. Dev. 62:105-120.
28. Luo, G., C. Hofmann, A, L. Bronckers, M. Sohocki, A. Bradley, and G. Karsenty. 1995. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9:2808-2820.
29. Mackie, G. G., and F. D. Stephens. 1975. Duplex kidneys: a correlation of renal dysplasia with position of the ureteral orifice. J. Urol. 114:274-280.
30. Miura, N., A. Wanaka, M. Tohyama, and K. Tanaka. 1993. MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett. 326:171-176.
31. Overdier, D. G., H. Ye, R. S. Peterson, D. E. Clevidence, and R. H. Costa. 1997. The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney. J. Biol. Chem. 272: 13725-13730.
32. Pelletier, G. J., S. L. Brody, H. Liapis, R. A. White, and B. P. Hackett. 1998. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am. J. Physiol. 274:L351-L359.
33. Pope, J. C. T., J. W. Brock 3rd, M. C. Adams, F. D. Stephens, and I. Ichikawa. 1999. How they begin and how they end: classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT. J. Am. Soc. Nephrol. 10:2018-2028.
34. Rosenthal, A. 1999. The GDNF protein family: gene ablation studies reveal what they really do and how. Neuron 22:201-203.
35. Sariola, H., and K. Sainio. 1997. The tip-top branching ureter. Curr. Opin. Cell Biol. 9:877-884.
36. Sasaki, H., and B. L. M. Hogan. 1993. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118:47-59.
37. Saxen, L. 1987. Organogenesis of the kidney. Cambridge University Press, Cambridge, England.
38. Stephens, F. D., and J. M. Husten. 1996. Congenital anomalies of the urinary and genital tracts. ISIS Medical Media, Oxford, England.
39. Swiderski, R. E., R. S. Reiter, D. Y. Nishimura, W. L. Alward, J. W. Kalenak, C. S. Searby, E. M. Stone, V. C. Sheffield, and J. J. Lin. 1999. Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. Dev. Dyn. 216:15-27.
40. Wakamiya, M., E. A. Lindsay, J. A. Rivera-Perez, A. Baldini, and R. R. Behringer. 1998. Functional analysis of Gscl in the pathogenesis of the DiGeorge and velocardiofacial syndromes. Hum. Mol. Genet. 7:1835-1840.
41. Wehr, R., A. Mansouri, T. de Maeyer, and P. Grass. 1997. Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development 124:4447-4456.
42. Winnier, G. E., L. Hargett, and B. L. M. Hogan. 1997. The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 11:926-940.
43. Winnier, G. E., T. Kume, K. Deng, R. Rogers, J. Bundy, C. Raines, M. A. Walter, B. L. M. Hogan, and S. J. Conway. 1999. Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev. Biol. 213:418-431.
44. Wu, S. C., J. Grindley, G. E. Winnier, L. Hargett, and B. L. M. Hogan. 1998. Mouse mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. Mech. Dev. 70:3-13.
45. Xuan, S., C. A. Baptista, G. Balas, W. Tao, V. C. Soares, and E. Lai. 1995. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14:1141-1152.