Cocultures of porcine hepatocytes and kupffer cells as an improved in vitro model for the study of hepatotoxic compounds

Veterinary Quarterly

Volumn 22, Issue 1, 2000, Pages 21-25

  Hoebe, K H N ^a   Monshouwer, M ^b   Witkamp, R F ^a,c   Fink Gremmels, J ^a   van Miert, A S J P A M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b PFIZER INC   (United States)

^c TNO   (Netherlands)

Author keywords

Chlorpromazine; Cocultures; Hepatocytes; Kupffer cells; Lipopolysaccharide; Porcine; Tiamulin

Indexed keywords

CHLORPROMAZINE; TIAMULIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; IMMUNE RESPONSE; KUPFFER CELL; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; SWINE;

ANIMALS; CELL COMMUNICATION; CELL CULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; KUPFFER CELLS; LIVER; SWINE; VETERINARY DRUGS; XENOBIOTICS;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0033984816     PISSN: 01652176     EISSN: 18755941     Source Type: Journal    
DOI: 10.1080/01652176.2000.9695018     Document Type: Article

References (29)

1. Bertoni G, Kuhnert P, Peterhans E, and Pauli U. Improved bioassay for the detection of porcine tumour necrosis factor using a homologous cell line: PK(15). J Immunol Methods 1993; 160 (2): 267–71.
2. Boehme CL, and Strobel HW. High-performance liquid chromatographic methods for the analysis of haloperidol and chlorpromazine metabolism in vitro by purified cytochromeP450 isoforms. J Chromatogr B BiomedScii Appl 1998; 718 (2): 259–66.
3. Calcarnuggi G, Lanzio M, Dughera L, Babini G, and Emanuelli G. Endotoxin tolerance and polymyxin B modify liver damageand cholestasis induced by a single dose of alphanaphthylisothiocyanate in the rat. Arch Toxicol 1992; 66 (2): 126–30.
4. Green LC, Wagner DA, Glogowski J, Skipper PL, and Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982; 126 (1): 131–8.
5. Hamada E, Nishida T, Uchiyama Y, Nakamura J, lsahara K, Kazuo H, et al. Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin. J Hepatol 1999; 30 (5): 807–18.
6. Hartung T, Sauer A, Hermann C, Brockhaus F, and Wendel A. Overactivation of the immune system by translocated bacteria and bacterial products. Scand J Gastroenterol Suppl 1997; 222: 98–9.
7. Heikkila RE, Cohen G, and Manian AA. Reactivity of various phenothiazine derivatives with oxygen and oxygen radicals. Biochem Pharmacol 1975; 24 (3): 363–8.
8. Helle M, Boeije L, and Aarden LA. Functional discrimination between interleukin 6 and interleukin 1. Eur J Immunol 1988; 18 (10): 1535–40.
9. Husztik E, Lazar G, and Parducz A. Electron microscopic study of Kupffer cell phagocytosis blockade induced by gadolinium chloride. Br J Exp Pathol 1980; 61 (6): 624–30.
10. Jeding I, Evans PJ, Akanmu D, Dexter D, Spencer JD, Aruoma OI, et al. Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs. Biochem Pharmacol 1995; 49 (3): 359–65.
11. Laskin DL. Nonparenchymal cells and hepatotoxicity. Semin Liver Dis 1990; 110 (4): 293–304.
12. Laskin DL, Pilaro AM, and Ji S. Potential role of activated macrophages in acetaminophen hepatotoxicity. li. Mechanism of macrophage accumulation and activation. Toxicol Appl Pharmacol 1986; 86 (2): 216–26.
13. Losser MR, and Payen D. Mechanisms of liver damage. Semin Liver Dis 1996; 16 (4): 357–67.
14. Mezes M, Salyi G, Banhidi G, and Szeberenyi S. Effect of acute salinomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiler chicken. Acta Vet Hung 1992; 40 (4): 251–7.
15. Monshouwer M, Witkamp RF, Nijmeijer SM, Amsterdam JG van, and Miert ASJPAM van. Suppression of cytochrome P450-and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes. Toxicol Appl Pharmacol 1996; 137 (2): 237–44.
16. Pall HS, Williams AC, and Blake DR. Iron, akathisia, and antipsychotic drugs [letter]. Lancet 1986; 2 (8521-22): 1469.
17. Pall HS, Williams AC, Blake DR, and Lunec J. Evidence of enhanced lipid peroxidation in the cerebrospinal fluid of patients taking phenothiazines. Lancet 1987; 2 (8559): 596–9.
18. Roth RA, Harkema JR, Pestka JP, and Ganey PE. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents? Toxicol Appl Pharmacol 1997; 147 (2): 300–11.
19. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29–83.
20. Smedsrod B, Pertoft H, Eggertsen G, and Sundstrom C. Functional and morphological characterization of cultures of Kupffer cells and liver endothelial cells prepared by means of density separation in Percoll, and selective substrate adherence, Cell Tissue Res 1985; 241 (3): 639–49.
21. Souhami RL, and Bradfield JW. The recovery of hepatic phagocytosis after blockade of Kupffer cells. J Reticuloendothel Soc 1974; 16 (2): 75–86.
22. Taylor MJ, Lafarge-Frayssinet C, Luster MI, and Frayssinet C. Increased endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin. Toxicol Appl Pharmacol 1991; 109 (1): 51–9.
23. Tjioc SA, Manian AA, and O’Neill JJ. Effects of superoxide dismutase on the autooxidation of 7, 8-dihydroxychlorpromazine in the presence of rat brain mitochondria. Psychopharmacol Commun 1975; 1 (4):373–81.
24. Traykov T, Hadjimitova V, Goliysky P, and Ribarov S. Effect of phenothiazines on activated macrophage-induced luminol-dependent chemiluminescence. Gen Physiol Biophys 1997; 16 (1): 3–14.
25. Trayner ID, Rayner AP, Freeman GE, and Farzaneh F. Quantitative multiwell myeloid differentiation assay using dichlorodihydrofluorescein diacetate (H2DCF-DA) or dihydrorhodamine 123 (H2R123). J Immunol Methods 1995; 186 (2): 275–84.
26. Watkins PB. Role of cytochromes P450 in drug metabolism and hepatotoxicity. Semin Liver Dis 1990; 10 (4): 235–50.
27. Winwood PJ, and Arthur MJ. Kupffer cells: their activation and role in animal models of liver injury and human liver disease. Semin Liver Dis 1993; 13 (1): 50–9.
28. Witkamp RF, Nijmeijer SM, Monshouwer M, and Miert ASJPAM van. The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig. Drug Metab Dispos 1995; 23 (5): 542–7.
29. Zweers-Zeilmaker WM, Miert ASJPAM van, Horbach GJ, and Witkamp RF. In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle. Res Vet Sci 1999; 66 (1): 51–5.