In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle

Research in Veterinary Science

Volumn 66, Issue 1, 1999, Pages 51-55

  Zweers Zeilmaker, W M ^a   Van Miert, A S J P A M ^a   Horbach, G J ^a   Witkamp, R F ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ERYTHROMYCIN; MACROLIDE; SPIRAMYCIN; TIAMULIN; TILMICOSIN; TROLEANDOMYCIN; TYLOSIN;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CATTLE; CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME INHIBITION; GOAT; LIVER; MICROSOME; NONHUMAN; RAT; SPECTROSCOPY; SWINE;

ANIMALIA; BOS TAURUS; BOVINAE; CAPRA HIRCUS; SUS SCROFA;

EID: 0033013847     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1053/rvsc.1998.0239     Document Type: Article

References (17)

1. BABANY, G., LARREY, D. & PESSAYRE, D. (1988) Macrolide antibiotics as inducers and inhibitors of cytochrome P-450 in experimental animals and man. In Progress in Drug Metabolism Vd. II. Ed. G.G. Gibson, London, Taylor and Francis, pp 61-98
2. DELAFORGE, M., LADAM, P., BOUILLÉ, G., CHARBI BENAROUS, J., JAOUEN, M. & GIRAULT, J.P. (1992) pH effects on the N-demethylation and formation of the cytochrome P-450 iron II nitrosoalkane complex for erythromycin derivates. Chemico-Biological Interactions 85, 215-227
3. FRANKLIN, M.R. (1991) Cytochrome P450 metabolic intermediate complexes from macrolide antibiotic and related compounds. Methods in Enzymology 206, 559-573
4. LACZAY, P., SIMON, F. & LEHEL, J. (1990) Investigations on the influence of monensin, tiamulin and of the simultaneous application of both substances on the activities of the microsomal mixed function oxygenases and of the formation of peroxides in broilers. Deutshe Tierärtzliche Wochenzeitschrift 97, 354-357
5. LINDSTROM, T.D., HANSSEN, B.R. & WRIGHTON, S.A. (1993) Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers. Antimicrobial Agents and Chemotheraphy 37, 265-269
6. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-275
7. NATSUHORI, M., VAN RAAK, M., LIGTENBERG, M., KLEY, L. TEN BERGE, D., ZWEERS-ZEILMAKER, W.M., DE GROENE, E.M., VAN MIERT, A.S.J.P.A.M., WITKAMP, R.F. & HORBACH, G.J. (1997) Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells. Environmental Toxicology and Pharmacology 3, 17-24
8. PESSAYRE, D., LARREY, D., VITAUX, J., BREIL, P., BELGHITI, J. & BENHAMOU, J.P. (1982) Formation of an inactive cytochrome P-450 Fe(II) -metabolite complex after administration of troleandomycin in humans. Biochemical Pharmacology 31, 1699-1704
9. ROOS, P.H., GOLUB-CIOSK, B., KALLWEIT, P., KAUCZINSKI, D. & HANSTEIN, W.G. (1993) Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes. Biochemical Pharmacology 45, 2239-2250
10. RUTTEN, A.A.J.J.L., FALKE, H.E., CATSBURG, J.F., TOPP, R., BLAAUBOER, B.J., HOLSTEYN VAN, I., DOORN, L. & VAN LEEUWEN, F.X.R. (1987) Interlaboratory comparison of total cytochrome P450 and protein determinations in rat liver microsomes. Archives of Toxicology 61, 27-33
11. VAN 'T KLOOSTER, G.A.E., HORBACH, G.J.M.J., NATSUHORI, M., BLAAUBOER, B.J., NOORDHOEK, J. & VAN MIERT, A.S.J.P.A.M. (1993) Hepatic cytochrome P450 induction in dwarf goats. Effects of model inducers on the metabolism of alkoxyresorufins, testosterone and ethylmorphine, and on apoprotein and mRNA levels. Biochemical Pharmacology 45, 113-118
12. WATKINS, P.B., WRIGHTON, S.A., SCHUETZ, E.G., MAUREL, P. & GUZELIAN, P.S. (1986). Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P450p in rat hepatocytes in vivo and in primary monolayer culture. Journal of Biological Chemistry 261, 6264-6271
13. WITKAMP, R.F., NIJMEIJER, S.M., MONSHOUWER, M. & VAN MIERT, A.S.J.P.A.M., (1995) The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex: Studies in primary hepatocyte cultures and liver microsomes of the pig. Drug Metabolism and Disposition 23, 542-547
14. WITKAMP, R.F., NIJMEIJER, S.M. & VAN MIERT, A.S.J.P.A.M. (1996) Cytochrome P-450 complex formation in rat liver by the antibiotic tiamulin. Antimicrobial Agents and Chemotheraphy 40, 50-54
15. WORTELBOER, H.M., KRUIF DE C.A., IERSEL VAN, A.A.J., FALKE H.E., NOORD HOEK, J. & BLAAUBOER, B.J. (1990) The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers. Biochemical Pharmacology 40, 2525-2534
16. WRIGHTON, S.A., MAUREL, P., SCHUETZ, E.G., WATKINS, P.B., YOUNG, B. & GUZELIAN, P.S. (1985) Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. Biochemistry 24 2171-2178
17. ZWEERS-ZEILMAKER, W.M., BATZIAS, J., MAAS, R.F.M., HORBACH, G.J., VAN MIERT, A.S.J.P.A.M. & WITKAMP, R.F. (1996) In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers. Xenobiotica 26, 1131-1141