Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR2A/ε1, an NMDA receptor subunit

British Journal of Pharmacology

Volumn 129, Issue 2, 2000, Pages 239-241

  Inoue, Makoto ^a   Mishina, Masayoshi ^b,c   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

NMDA; Spinal cord; Substance P; Supersensitization

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; BRADYKININ; CAPSAICIN; DIZOCILPINE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROKININ 1 RECEPTOR ANTAGONIST; RECEPTOR SUBUNIT; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MALE; MOUSE; NERVE STIMULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE;

EID: 0033979591     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703056     Document Type: Article

References (20)

1. Coggeshall, R.E. & Carlton, S.M. (1998). Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery. J. Comp. Neurol., 391, 78-86.
2. Hiura, A. & Ishizuka, H. (1989). Changes in features of degenerating primary sensory neurons with time after capsaicin treatment. Acta. Neuropathol. (Berl), 78, 35-46.
3. Hylden, J.L. & Wilcox, G.L. (1980). Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol., 67, 313-316.
4. Hylden, J.L. & Wilcox, G.L. (1981). Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice. Brain Res., 217, 212-215.
5. Inoue, M., Kobayashi, M., Kozaki, S., Zimmer, A. & Ueda, H. (1998a). Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc. Natl. Acad. Sci. U.S.A., 95, 10949-10953.
6. Inoue, M., Nakayamada, H., Tokuyama, S. & Ueda, H. (1997). Peripheral non-opioid analgesic effects of kyotorphin in mice. Neurosci Lett., 236, 60-62.
7. Inoue, M., Shimohira, I., Yoshida, A., Zimmer, A., Takeshima, H., Sakurada, T., Ueda, H. (1999). Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. J. Pharmacol. Exp. Ther., 291, 308-313.
8. Inoue, M., Tokuyama, S., Nakayamada, H. & Ueda, H. (1998b). In vivo signal transduction of tetrodotoxin-sensitive nociceptive responses by substance P given into the planta of the mouse hind limb. Cell Mol. Neurobiol., 18, 555-561.
9. Inoue, T., Mashimo, T., Shibata, M., Shibuta, S. & Yoshiya, I. (1998c). Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model. Brain Res., 792, 263-270.
10. Kiyama, Y., Manabe, T., Sakimura, K., Kawakami, F., Mori, H. & Mishina, M. (1998). Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon 1 subunit. J. Neurosci., 18, 6704-6712.
11. Liu, H., Brown, J.L., Jasmin, L., Maggio, J.E., Vigna, S.R., Mantyh, P.W. & Basbaum, A.I. (1994). Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc. Natl. Acad. Sci. U.S.A., 91, 1009-1013.
12. Liu, H., Mantyh, P.W. & Basbaum, A.I. (1997). NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature, 386, 721-724.
13. Mantyh, P.W. & Hunt, S.P. (1985). The autoradiographic localization of substance P receptors in the rat and bovine spinal cord and the rat and cat spinal trigeminal nucleus pars caudalis and the effects of neonatal capsaicin. Brain Res., 332, 315-324.
14. Melzack, R. & Wall, P.D. (1965). Pain mechanisms: a new theory. Science, 150, 971-979.
15. Murray, C.W., Cowan, A. & Larson, A.A. (1991). Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain, 44, 179-185.
16. Nishiyama, T., Yaksh, T.L. & Weber, E. (1998). Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine. Anesthesiology, 89, 715-722.
17. Okano, K., Kuraishi, Y., & Satoh, M. (1998). Involvement of spinal substance P and excitatory amino acids in inflammatory hyperalgesia in rats. Jpn. J. Pharmacol., 76, 15-22.
18. Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., Yagi, T., Aizawa, S., Inoue, Y., Sugiyama, H. & Mishina (1995). Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature, 373, 151-155.
19. Ueda, H. (1999). In vivo molecular signal transduction of peripheral mechanisms of pain. Jpn. J. Pharmacol., 79, 263-268.
20. Zimmermann, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109-110.