Peripheral non-opioid analgesic effects of kyotorphin in mice

Neuroscience Letters

Volumn 236, Issue 1, 1997, Pages 60-62

  Inoue, Makoto ^a   Nakayamada, Hiroyuki ^a   Tokuyama, Shogo ^a   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Bradykinin; G protein; Hoe 140; Kyotorphin; Leucine arginine; Non opioid; Peripheral analgesia; Pertussis toxin (PTX)

Indexed keywords

ANALGESIC AGENT; BESTATIN; BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; ENKEPHALIN; GUANINE NUCLEOTIDE BINDING PROTEIN; ICATIBANT; KYOTORPHIN; LEUCYLARGININE; NALOXONE; NEUROPEPTIDE; PERTUSSIS TOXIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; FLEXOR REFLEX; FOOT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AFFERENT PATHWAYS; ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDORPHINS; MALE; MICE; PAIN; RECEPTORS, BRADYKININ;

EID: 0031585499     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00760-X     Document Type: Article

References (9)

1. Harima A., Shimizu H., Takagi H. Analgesic effect of L-arginine in patients with persistent pain. Eur. Neuropsychopharmacol. 1:1991;529-533.
2. Kawabata A., Nishimura Y., Takagi H. L-Leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia. Br. J. Pharmacol. 107:1992;1096-1101.
3. Kawabata A., Muguruma H., Tanaka M., Takagi H. Kyotorphin synthetase activity in rat adrenal glands and spinal cord. Peptide. 17:1996;407-411.
4. Takagi H., Shiomi H., Ueda H., Amano H. A novel analgesic dipeptide from bovine brain in a possible Met-enkephalin releaser. Nature. 282:1979;410-412.
5. Takagi, H. and Ueda, H., Kyotorphin as an endogenous pain modulator. In H. Takagi, Y. Oomura, H. Ito and M. Otsuka (Eds.), The Biowarning System in the Brain, University of Tokyo Press, Tokyo, 1988, pp. 139-153.
6. Ueda H., Ming G.E., Hazata T., Katayama T., Takagi H. Degradation of kyotorphin by a purified membrane-bound-aminopeptidase from monkey brain: potentiation of kyotorphin-induced analgesia by a highly effective inhibitor, bestatin. Life Sci. 36:1985;1865-1871.
7. Ueda H., Yoshihara Y., Fukushima N., Shiomi H., Nakamura A., Takagi H. Kyotorphin (tyrosyl-arginine) synthetase in rat brain synaptosomes. J. Biol. Chem. 262:1987;8165-8173.
8. Ueda H., Yoshihara Y., Ming G.E., Sugiyama W.I., Dodo M., Takagi H., Satoh M. Involvement of kyotorphin and kyotorphin synthetase in the pain modulation. Jpn. J. Pharmacol. 46(Suppl.):1988;248P.
9. Ueda H., Yoshihara Y., Misawa H., Fukushima N., Katada T., Ui M., Takagi H., Satoh M. The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi measured with GTPase and phospholipase C assays. J. Biol. Chem. 264:1989;3732-3741.