T-cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis

Infection and Immunity

Volumn 68, Issue 2, 2000, Pages 502-510

  Chang, W L ^a   Audet, R G ^b   Aizenstein, B D ^b   Hogan, L H ^b   DeMars, R I ^b   Klein, B S ^b,c,d  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; WI 1 ANTIGEN;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BLASTOMYCES DERMATITIDIS; BLASTOMYCOSIS; CELL CLONE; CONTROLLED STUDY; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANTIGENS, FUNGAL; BLASTOMYCES; BLASTOMYCOSIS; EPITOPES, T-LYMPHOCYTE; HLA ANTIGENS; HLA-DP ANTIGENS; HLA-DR ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 0033979226     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.2.502-510.2000     Document Type: Article

References (25)

1. Audet, R., T. T. Brandhorst, and B. Klein. 1997. Purification in quantity of the secreted form of WI-1: a major adhesin on Blastomyces dermatitidis yeasts. Protein Expr. Purif. 11:214-226.
2. Brandhorst, T. T., M. Wuthrich, T. Warner, and B. Klein. 1999. Targeted disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis. J. Exp. Med. 189:1207-1216.
3. Chauhan, B., A. P. Knutsen, P. S. Hutcheson, R. G. Slavin, and C. L. Bellone. 1996. T cell subsets, epitope mapping, and HLA-restriction in patients with allergic bronchopulmonary aspergillosis. J. Clin. Investig. 97: 2324-2331.
4. Coligan, J. E., A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober. 1994. Current protocols in immunology, vol. I. John Wiley & Sons, Inc., New York, N.Y.
5. Cozad, G. C., and C.-T. Chang. 1980. Cell-mediated immunoprotection in blastomycosis. Infect. Immun. 28:398-403.
6. Deepe, G. S., R. Gibbons, G. D. Brunner, and F. J. Gomez. 1996. A protective domain of heat-shock protein 60 from Histoplasma capsulatum. J. Infect. Dis. 174:828-834.
7. Deepe, G. S. 1997. Prospects for the development of fungal vaccines. Clin. Microbiol. Rev. 10:585-596.
8. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308-1310.
9. Hogan, L. H., S. Josvai, and B. S. Klein. 1995. Genomic cloning, characterization, and functional analysis of the major surface adhesin WI-1 on Blastomyces dermatitidis yeasts. J. Biol. Chem. 270:30725-30732.
10. Klein, B. S., J. M. Vergeront, R. J. Weeks, U. N. Kumar, G. Mathai, B. Varkey, L. Kaufman, R. W. Bradsher, J. F. Stoebig, and J. P. Davis. 1986. Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin. N. Engl. J. Med. 314:529-534.
11. Klein, B. S., and J. M. Jones. 1990. Isolation, purification, and radiolabeling of a novel 120-kD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients. J. Clin. Investig. 85:152-161.
12. Klein, B. S., P. M. Sondel, and J. M. Jones. 1992. WI-1, a novel 120-kilodalton surface protein on Blastomyces dermatitidis yeast cells, is a target antigen of cell-mediated immunity in human blastomycosis. Infect. Immun. 60:429-4300.
13. Klein, B. S., L. H. Hogan, and J. M. Jones. 1993. Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis. J. Clin. Investig. 92:330-337.
14. Lampson, L. A., and R. Levy. 1980. Two populations of IA-like molecules on a human B-cell line. J. Immunol. 125:293.
15. Meyer, C. G., and M. J. Schnittger. 1997. HLA-DP - part of the concert. Immunol. Today 18:58-61.
16. Murray, J. S. 1998. How MHC selects Th1/TH2 immunity. Immunol. Today 19:157-163.
17. Newman, S. L., S. Chaturvedi, and B. S. Klein. 1995. The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) anil CD14. J. Immunol. 154:753-761.
18. Ortiz, L., K. P. Demick, J. W. Petersen, M. Polka, A. R. Rudersdorf, B. Van der Pol, R. Jones, M. Angevine, and R. DeMars. 1996. Chlamydia trachomatis major outer membrane protein (MOMP) epitopes that activate HLA class II-restricted T cells from infected humans. J. Immunol. 157:4554-4567.
19. Pappas, P. G., J. C. Pottage, W. G. Powderly, V. J. Fraser, C. W. Stratton, S. McKenzie, M. L. Tapper, H. Chmel, F. C. Bonebrake, R. Blum, et al. 1992. Blastomycosis in patients with the acquired immunodeficiency syndrome. Ann. Intern. Med. 116:847-853.
20. Pappas, P. G., M. G. Threlkeld, G. D. Bedsole, K. O. Cleveland, M. S. Gelfand, and W. E. Dismukes. 1993. Blastomycosis in immunocompromised patients. Medicine 72:311-325.
21. Parham, P., T. J. Kipps, F. E. Ward, and L. A. Herzenberg. 1983. Isolation of heavy chain class I switch variants of a monoclonal anti-DC1 hybridoma cell line: effective conversion of noncytotoxic IgG1 to cytotoxic IgG2 antibodies. Hum. Immunol. 8:141.
22. Perez, M. S., R. D. Orejas, J. W. Petersen, R. I. DeMars, and S. Shaw. 1990. Differences in specificity of DPw2-specific cytotoxic T-cell clones revealed with HLA mutant lines: evidence that non-DP HLA genes influence recognition by some clones. Eur. J. Immunol. 20:673-681.
23. Watson, A. J., R. DeMars, I. S. Trowbridge, and F. H. Bach. 1983. Detection of a novel human class II HLA antigen. Nature 304:358.
24. Worsham, P. L., and W. E. Goldman. 1988. Quantitative plating of Histoplasma capsulatum without addition of conditioned medium or siderophores. J. Med. Vet. Mycol. 26:137-143.
25. Wuthrich, M., W. L. Chang, and B. S. Klein. 1998. Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis. Infect. Immun. 66:5443-5449.