Activation of the mesocorticolimbic dopaminergic system by stimulation of muscarinic cholinergic receptors in the ventral tegmental area

Psychopharmacology

Volumn 147, Issue 4, 2000, Pages 347-355

  Gronier, Benjamin ^a   Perry, Kenneth W ^a   Rasmussen, Kurt ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

A10 region; Mesocorticolimbic dopaminergic system; Microdialysis; Muscarinic receptor

Indexed keywords

DOPAMINE; METHYLSCOPOLAMINE; MUSCARINIC RECEPTOR; NORADRENALIN; OXOTREMORINE; SEROTONIN;

AGITATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FRONTAL CORTEX; MALE; MOTOR PERFORMANCE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; VENTRAL TEGMENTUM;

EID: 0033977710     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050002     Document Type: Article

References (46)

1. Bernard V, Legay C, Massoulie J, Bloch B (1995) Anatomical analysis of the neurons expressing the acetylcholinesterase gene in the rat brain, with special reference to the striatum. Neuroscience 64:995-1005
2. Blaha CD, Alien LF, Das S, Inglis WL, Latimer MP, Vincent SR, Winn P (1996) Modulation of dopamine efflux in the nucleus accumbens after cholinergic stimulation of the ventral tegmental area in intact, pedunculopontine tegmental nucleus-lesioned, and laterodorsal tegmental nucleus-lesioned rats. J Neurosci 16:714-722
3. Butcher LL (1977) Nature and mechanisms of cholinergic-monoaminergic interactions in the brain. Life Sci 21:1207-1226
4. Butcher LL, Woolf NJ (1982) Monoaminergic-cholinergic relationships and the chemical communication matrix of the substantia nigra and neostriatum. Brain Res Bull 9:475-492
5. Bymaster FP, Shannon HE, Rasmussen K, Delapp NW, Mitch CH, Ward JS, Calligaro DO, Ludvigsen TS, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P, Fink-Jensen A (1998) Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabi-cyclo[3.2.1]octane. Eur J Pharmacol 356:109-119
6. Cheramy A, Leviel V, Glowinski J (1981) Dendritic release of dopamine in the substantia nigra. Nature 289:537-542
7. Clarke PB, Pert A (1985) Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons. Brain Res 348:355-358
8. 125I]-alpha-bungarotoxin. J Neurosci 5:1307-1315
9. Fink-Jensen A, Kristensen P, Shannon HE, Calligaro DO, Delapp NW, Whitesitt C, Ward JS, Thomsen C, Rasmussen T, Sheardown MJ, Jeppesen L, Sauerberg P, Bymaster FP (1998) Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats. NeuroReport 9:3481-3486
10. Freed C, Revay R, Vaughan RA, Kriek E, Grant S, Uhl GR, Kuhar MJ (1995) Dopamine transporter inimunoreactivity in rat brain. J Comp Neurol 359:340-349
11. Garcia-Rill E, Biedermann JA, Chambers T, Skinner RD, Mrak RE, Husain M, Karson CN (1995) Mesopontine neurons in schizophrenia. Neuroscience 66:321-335
12. Garzon M, Vaughan A, Uhl R, Kuhar MJ, Pickel VM (1999) Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter. J Comp Neurol 410:197-210
13. Grenhoff J, Aston-Jones G, Svensson TH (1986) Nicotinic effects on the firing pattern of midbrain dopamine neurons. Acta Physiol Scand 128:351-358
14. Gronier B, Rasmussen K (1998) Activation of midbrain presumed dopaminergic neurones by muscarinic cholinergic receptors: an in vivo electrophysiological study in the rat. Br J Pharmacol 124:455-464
15. Gronier B, Rasmussen K (1999) Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons. Neuropharmacology (in press)
16. Guan XM, McBride WJ (1989) Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. Brain Res Bull 23:541-547
17. Henderson Z, Sherriff FE (1991) Distribution of choline acetyl-transferase immunoreactive axons and terminals in the rat and ferret brainstem. J Comp Neurol 314:147-163
18. Herve D, Pickel VM, Joh TH, Beaudet A (1987) Serotonin terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons. Brain Res 435:71-83
19. Ikemoto S, Kohl RR, McBride WJ (1997) GABA(A) receptor blockade in the anterior ventral tegmental area increases extra-cellular levels of dopamine in the nucleus accumbens of rats. J Neurochem 69:137-143
20. Knable MB, Weinberger DR (1997) Dopamine, the prefrontal cortex and schizophrenia. J Psychopharmacol 11:123-131
21. Kohl RR, Katner JS, Chernet E, McBride WJ (1998) Ethanol and negative feedback regulation of mesolimbic dopamine release in rats. Psychopharmacology 139:79-85
22. 1-like receptors. J Pharmacol Exp Ther 253:395-400
23. 2 muscarine receptors in the rat brain. Neuroscience 19:551-564
24. Mereu G, Yoon KWP, Boi, V, Gessa, GL, Naes L, Thomas C (1987) Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur J Pharmacol 141:395-399
25. Niijima K, Yoshida M (1988) Activation of mesencephalic dopamine neurons by chemical stimulation of the nucleus tegmenti pedunculopontinus pars compacta. Brain Res 451:163-171
26. Nisell M, Nomikos GG, Svensson TH (1994a) Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area. Synapse 16:36-44
27. Nisell M, Nomikos GG, Svensson TH (1994b) Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release. Pharmacol Toxicol 75:348-352
28. Nisell M, Nomikos GG, Hertel P, Panagis G, Svensson TH (1996) Condition-independent sensitisation of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat. Synapse 22:369-381
29. Nissbrandt H, Sundstrom E, Jonsson G, Hjorth S, Carlsson A (1989) Synthesis and release of dopamine in rat brain: comparison between substantia nigra pars compacts, pars reticulata, and striatum. J Neurochem 52:1170-1182
30. Oades RD, Halliday GM (1987) Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity. Brain Res 434:117-165
31. Oakman SA, Faris PL, Kerr PE, Cozzari C, Hartman BK (1995) Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J Neurosci 15:5859-5869
32. Perry KW, Bymaster F, Shannon H, de Lapp N, Ward J, Whitesitt C, Fink-Jensen A, Sherdown M, Sauerberg P (1997) Effects of xanomeline on monoamine neurotransmitters and metabolites in rat brain areas as measured by microdialysis. Neurosci Abstr 785.15
33. Schilstrom B, Nomikos GG, Nisell M, Hertel P, Svensson TH (1998) N-Methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience 82:781-789
34. Takahashi H, Takada Y, Nagai N, Urano T, Takada A (1998) Nicotine increases stress-induced serotonin release by stimulating nicotinic acetylcholine receptor in rat striatum. Synapse 28:212-219
35. Tandon R, Mann NA, Eisner WH, Coppard N (1990) Effect of anticholinergic medication on positive and negative symptoms in medication-free schizophrenic patients. Psychiatry Res 31:235-241
36. Tandon R, Shipley JE, Greden JF, Mann NA, Eisner WH, Goodson JA (1991) Muscarinic cholinergic hyperactivity in schizophrenia. Relationship to positive and negative symptoms. Schizophr Res 4:23-30
37. Toth E, Sershen H, Hashim A, Vizi ES, Lajtha A (1992) Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: role of glutamic acid. Neurochem Res 17:265-271
38. Villaro MT, Palacios JM, Mengod G (1990) Localisation of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridisation histochemistry. Neurosci Lett 114:154-159
39. Weiner DM, Levey AI, Brann MR (1990) Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia. Proc Natl Acad Sci USA 87:7050-7054
40. Westerink BH, Santiago M, de Vries JB (1992) In vivo evidence for a concordant response of terminal and dendritic dopamine release during intranigral infusion of drugs. Naunyn-Schmiedeberg's Arch Pharmacol 346:637-643
41. Westerink BH, Kwint HF, de Vries JB (1996) The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain. J Neurosci 16:2605-2611
42. Westerink BH, Enrico P, Feimann J, de Vries JB (1998) The pharmacology of mesocortical dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and prefrontal cortex of the rat brain. J Pharmacol Exp Ther 285:143-154
43. White FJ, Wang RY (1984) A10 dopamine neurons: role of autoreceptors in determining firing rate and sensitivity to dopamine agonists. Life Sci 34:1161-1170
44. Yeomans JS (1995) Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia. Neuropsychopharmacology 12:3-16
45. Yeomans JS, Mathur A, Tampakeras M (1993) Rewarding brain stimulation: role of tegmental cholinergic neurons that activate dopamine neurons. Behav Neurosci 107:1077-1087
46. Zemishlany Z, Aizenberg D, Weiner Z, Weizman A (1996) Trihexyphenidyl (Arlane) abuse in schizophrenic patients. Int Clin Psychopharmacol 11:199-202