메뉴 건너뛰기




Volumn 9, Issue 2, 1996, Pages 397-402

Formation and differential removal of C-8 and N2-guanine adducts of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in the liver, kidney, and colorectum of the rat

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; CARCINOGEN; DNA;

EID: 0029969649     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950131r     Document Type: Article
Times cited : (35)

References (51)
  • 1
    • 0023894247 scopus 로고
    • Successful use of short-term tests for academic purposes. Their use in identification of new environmental carcinogens with possible risk for humans
    • Sugimura, T. (1988) Successful use of short-term tests for academic purposes. Their use in identification of new environmental carcinogens with possible risk for humans. Mutat Res. 205, 33-39.
    • (1988) Mutat Res. , vol.205 , pp. 33-39
    • Sugimura, T.1
  • 2
    • 0027527140 scopus 로고
    • Carcinogenic factors in food with relevance to colon cancer development
    • Nagao, M., and Sugimura, T. (1993) Carcinogenic factors in food with relevance to colon cancer development. Mutat. Res. 290, 43-51.
    • (1993) Mutat. Res. , vol.290 , pp. 43-51
    • Nagao, M.1    Sugimura, T.2
  • 5
    • 0000918297 scopus 로고
    • Heterocyclic-amine mutagens/carcinogens in foods
    • (Cooper, C. S., and Grover, P. L., Eds.) Springer-Verlag, Berlin and Heidelberg
    • Felton, J. S., and Knize, M. G. (1990) Heterocyclic-amine mutagens/carcinogens in foods. In Handbook of Experimental Pharmacology (Cooper, C. S., and Grover, P. L., Eds.) Vol. 94/I. pp 471-502. Springer-Verlag, Berlin and Heidelberg.
    • (1990) Handbook of Experimental Pharmacology , vol.94 , Issue.1 , pp. 471-502
    • Felton, J.S.1    Knize, M.G.2
  • 6
    • 0025986958 scopus 로고
    • Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in cigarette smoke condensate
    • Manabek, S., Tohyama, K., Wada, O., and Aramaki, T. (1991) Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in cigarette smoke condensate. Carcinogenesis 12, 1945-1947.
    • (1991) Carcinogenesis , vol.12 , pp. 1945-1947
    • Manabek, S.1    Tohyama, K.2    Wada, O.3    Aramaki, T.4
  • 8
    • 0021015045 scopus 로고
    • Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate
    • Yamazoe, Y., Shimada, M., Shinohara, A., Saito, K. Kamataki, T., and Kato, R. (1983) Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate. Cancer Res. 43, 5768-5774.
    • (1983) Cancer Res. , vol.43 , pp. 5768-5774
    • Yamazoe, Y.1    Shimada, M.2    Shinohara, A.3    Saito, K.4    Kamataki, T.5    Kato, R.6
  • 9
    • 0022566931 scopus 로고
    • Metabolic activation of mutagenic heterocyclic amines from protein pyrolysates
    • Kato, R. (1986) Metabolic activation of mutagenic heterocyclic amines from protein pyrolysates. CRC Crit. Rev. Toxicol. 16, 308-347.
    • (1986) CRC Crit. Rev. Toxicol. , vol.16 , pp. 308-347
    • Kato, R.1
  • 10
    • 0024365294 scopus 로고
    • Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA1535/pSk1002
    • Shimada, T., Iwasaki, M., Martin, M. V., and Guengerich, F. P. (1989) Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA1535/pSk1002. Cancer Res. 49, 3218-3228.
    • (1989) Cancer Res. , vol.49 , pp. 3218-3228
    • Shimada, T.1    Iwasaki, M.2    Martin, M.V.3    Guengerich, F.P.4
  • 11
    • 0024343858 scopus 로고
    • Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
    • Butler, M. A., Iwasaki, M. Guengerich, F. P., and Kadlubar, F. F. (1989) Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc. Natl. Acad. Sci. U.S.A. 86, 7696-7700.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 7696-7700
    • Butler, M.A.1    Iwasaki, M.2    Guengerich, F.P.3    Kadlubar, F.F.4
  • 12
    • 0025251678 scopus 로고
    • The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat hepatocytes
    • Turesky, R. J., Bracco-Hammer, I., Markovic, J., Richli, U., Kappeler, A. M., and Welti, D. H. (1990) The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat hepatocytes. Chem. Res. Toxicol, 3, 524-535.
    • (1990) Chem. Res. Toxicol , vol.3 , pp. 524-535
    • Turesky, R.J.1    Bracco-Hammer, I.2    Markovic, J.3    Richli, U.4    Kappeler, A.M.5    Welti, D.H.6
  • 13
    • 0026040316 scopus 로고
    • Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
    • Turesky, R. J., Lang, N. P., Butler, M. A., Teitel, C. H., and Kadlubar, F. F. (1991) Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon Carcinogenesis 12, 1839-1845.
    • (1991) Carcinogenesis , vol.12 , pp. 1839-1845
    • Turesky, R.J.1    Lang, N.P.2    Butler, M.A.3    Teitel, C.H.4    Kadlubar, F.F.5
  • 14
    • 0027104865 scopus 로고
    • N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver
    • Rich, K. J., Murray, B. P., Lewis, L., Rendell, N. B., Davies, D. S., Gooderham, N. J., and Boobis, A. R. (1992) N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. Carcinogenesis 13, 221-226.
    • (1992) Carcinogenesis , vol.13 , pp. 221-226
    • Rich, K.J.1    Murray, B.P.2    Lewis, L.3    Rendell, N.B.4    Davies, D.S.5    Gooderham, N.J.6    Boobis, A.R.7
  • 15
    • 0025013470 scopus 로고
    • Role of sulfation and acetylation in the activation of 2-hydroxyamino amino-1-methylimidazo[4,5-b]pyridine to intermediates which bind DNA
    • Buonarati, M H., Turteltaub, K. W., Shen, N. H., and Felton, J. S. (1990) Role of sulfation and acetylation in the activation of 2-hydroxyamino amino-1-methylimidazo[4,5-b]pyridine to intermediates which bind DNA. Mutat. Res. 245, 185-190.
    • (1990) Mutat. Res. , vol.245 , pp. 185-190
    • Buonarati, M.H.1    Turteltaub, K.W.2    Shen, N.H.3    Felton, J.S.4
  • 16
    • 0027369714 scopus 로고
    • Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats
    • Davis, C. D., Schut, H. A. J., and Snyderwine, E. G. (1993) Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats. Carcinogenesis 14, 2091-2096.
    • (1993) Carcinogenesis , vol.14 , pp. 2091-2096
    • Davis, C.D.1    Schut, H.A.J.2    Snyderwine, E.G.3
  • 17
    • 0028904047 scopus 로고
    • Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methylimidazo[4,5-bpyridine by hepatic microsomes and cytosols from humans, rats, and mice
    • Lin, D-X., Lang, N. P., and Kadlubar, F. F. (1995) Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methylimidazo[4,5-b)pyridine by hepatic microsomes and cytosols from humans, rats, and mice. Drug Metab. Dispos. 23, 518-524.
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 518-524
    • Lin, D.-X.1    Lang, N.P.2    Kadlubar, F.F.3
  • 18
    • 0023485764 scopus 로고
    • Mechanisms of nutritional carcinogenesis associated with specific human cancers
    • Weisburger, J H (1987) Mechanisms of nutritional carcinogenesis associated with specific human cancers ISI Atlas Sci., Pharmacol 1, 162-167.
    • (1987) ISI Atlas Sci., Pharmacol , vol.1 , pp. 162-167
    • Weisburger, J.H.1
  • 19
    • 0017815884 scopus 로고
    • Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential address
    • Miller, E. C. (1978) Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential address. Cancer Res 38, 1479-1496.
    • (1978) Cancer Res , vol.38 , pp. 1479-1496
    • Miller, E.C.1
  • 20
    • 0027493111 scopus 로고
    • Endogenous DNA adducts: Potential and paradox
    • Marnett, L. J., and Burcham, P. C. (1993) Endogenous DNA adducts: Potential and paradox Chem. Res. Toxicol. 6, 771-785.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 771-785
    • Marnett, L.J.1    Burcham, P.C.2
  • 21
    • 0023883437 scopus 로고
    • Reaction of the N-hydroxylanime and N-acetoxy derivatives of 2-amino-3-methylimidazo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ
    • Snyderwine, E. G., Roller, P. P., Adamson, R. H., Sato, S., and Thorgeirsson, S.S. (1988) Reaction of the N-hydroxylanime and N-acetoxy derivatives of 2-amino-3-methylimidazo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ. Carcinogenesis 9, 1061-1065.
    • (1988) Carcinogenesis , vol.9 , pp. 1061-1065
    • Snyderwine, E.G.1    Roller, P.P.2    Adamson, R.H.3    Sato, S.4    Thorgeirsson, S.S.5
  • 24
    • 0023749970 scopus 로고
    • DNA adduct formation of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in target tissues of the F-344 rat
    • Schut, H. A. J., Putman, K., and Randerath, K. (1988) DNA adduct formation of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in target tissues of the F-344 rat. Cancer Lett. 41, 345-352.
    • (1988) Cancer Lett. , vol.41 , pp. 345-352
    • Schut, H.A.J.1    Putman, K.2    Randerath, K.3
  • 25
    • 0026045738 scopus 로고
    • Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline in male Fischer-344 rats
    • Zu, H.-X., and Schut, H. A. J. (1991) Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline in male Fischer-344 rats. Cancer Res. 51, 5636-5641.
    • (1991) Cancer Res. , vol.51 , pp. 5636-5641
    • Zu, H.-X.1    Schut, H.A.J.2
  • 27
    • 0027337830 scopus 로고
    • 32P-Postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys
    • 32P-Postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys. Carcinogenesis 14, 1389-1395.
    • (1993) Carcinogenesis , vol.14 , pp. 1389-1395
    • Snyderwine, E.G.1    Davis, C.D.2    Nouso, K.3    Roller, P.P.4    Schut, H.A.J.5
  • 29
    • 0026521988 scopus 로고
    • Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells
    • Pfau, W., O'Hare, M. J., Grover, P. L., and Phillips, D. H. (1992) Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells. Carcinogenesis 13, 907-909.
    • (1992) Carcinogenesis , vol.13 , pp. 907-909
    • Pfau, W.1    O'Hare, M.J.2    Grover, P.L.3    Phillips, D.H.4
  • 32
    • 0029166942 scopus 로고
    • DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in liver, kidney, and colo-rectum of rats
    • Turesky, R. J., and Markovic, J. (1995) DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in liver, kidney, and colo-rectum of rats. Carcinogenesis 16, 2275-2279.
    • (1995) Carcinogenesis , vol.16 , pp. 2275-2279
    • Turesky, R.J.1    Markovic, J.2
  • 33
    • 0000656139 scopus 로고
    • Chemical properties of ultimate carcinogenic metabolites of arylamines and arylamides
    • (Harvey, R. G., Ed) ACS Symposium Series 283, American Chemical Society, Washington, DC
    • Kadlubar, F. F., and Beland, F. A. (1985) Chemical properties of ultimate carcinogenic metabolites of arylamines and arylamides. In Polycyclic Hydrocarbons and Carcinogenesis (Harvey, R. G., Ed) ACS Symposium Series 283, pp 331-370, American Chemical Society, Washington, DC.
    • (1985) Polycyclic Hydrocarbons and Carcinogenesis , pp. 331-370
    • Kadlubar, F.F.1    Beland, F.A.2
  • 34
    • 0022273489 scopus 로고
    • Formation and persistence of arylamine DNA adducts in vivo
    • Beland, F. A., and Kadlubar, F F. (1985) Formation and persistence of arylamine DNA adducts in vivo. Environ. Health Perspect. 62, 19-30.
    • (1985) Environ. Health Perspect. , vol.62 , pp. 19-30
    • Beland, F.A.1    Kadlubar, F.F.2
  • 35
    • 0027052264 scopus 로고
    • DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: Implications for DNA adduct-based human cancer risk assessment
    • Poirier, M. C., and Beland, F. A. (1992) DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: Implications for DNA adduct-based human cancer risk assessment. Chem. Res. Toxicol. 5, 749-755.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 749-755
    • Poirier, M.C.1    Beland, F.A.2
  • 36
    • 0029043747 scopus 로고
    • Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
    • Hirose, M., Wakabayashi, K., Ochiai, M., Kushida, H., Sato, H., Sugimura, T., and Nagao, M. (1995) Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Jpn. J. Cancer Res. 86, 516-522.
    • (1995) Jpn. J. Cancer Res. , vol.86 , pp. 516-522
    • Hirose, M.1    Wakabayashi, K.2    Ochiai, M.3    Kushida, H.4    Sato, H.5    Sugimura, T.6    Nagao, M.7
  • 37
    • 0021985758 scopus 로고
    • Formation of DNA adducts in vivo in rat liver and intestinal epithelium after adminstration of the carcinogen 3,2′-dimethyl-4-aminobiphenyl and its hydroxamic acid
    • Westra, J. G., Flammang, T. J., Fullerton, N. F., Beland, F. A., Weis, C. C., and Kadlubar, F. F. (1985) Formation of DNA adducts in vivo in rat liver and intestinal epithelium after adminstration of the carcinogen 3,2′-dimethyl-4-aminobiphenyl and its hydroxamic acid. Carcinogenesis 6, 37-44.
    • (1985) Carcinogenesis , vol.6 , pp. 37-44
    • Westra, J.G.1    Flammang, T.J.2    Fullerton, N.F.3    Beland, F.A.4    Weis, C.C.5    Kadlubar, F.F.6
  • 38
    • 0024417541 scopus 로고
    • Formation and removal of DNA adducts in target and nontarget tissue of rats adminstrered multiple doses of 2-acetylaminophenanthrene
    • Gupta, R. C., Earley, K., Fullerton, N. F., and Beland, F. A. (1989) Formation and removal of DNA adducts in target and nontarget tissue of rats adminstrered multiple doses of 2-acetylaminophenanthrene. Carcinogenesis 10, 2025-2033.
    • (1989) Carcinogenesis , vol.10 , pp. 2025-2033
    • Gupta, R.C.1    Earley, K.2    Fullerton, N.F.3    Beland, F.A.4
  • 39
    • 0028138832 scopus 로고
    • Removal of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the male Fischer-344 rat
    • Cummings, D. A., and Schut, H. A. J. (1994) Removal of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the male Fischer-344 rat Carcinogenesis 15, 2623-2628.
    • (1994) Carcinogenesis , vol.15 , pp. 2623-2628
    • Cummings, D.A.1    Schut, H.A.J.2
  • 40
    • 0019275121 scopus 로고
    • Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene
    • Evans, F. E., Miller, D. W., and Beland, F. A. (1980) Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene. Carcinogenesis 1, 955-959.
    • (1980) Carcinogenesis , vol.1 , pp. 955-959
    • Evans, F.E.1    Miller, D.W.2    Beland, F.A.3
  • 41
    • 0020972622 scopus 로고
    • Induction of the base displacement or Z conformation in DNA by N-2-acetylaminofluorene
    • Santella, R M., and Grunberger, D. (1983) Induction of the base displacement or Z conformation in DNA by N-2-acetylaminofluorene Envrion. Health Perspect. 49, 107-115.
    • (1983) Envrion. Health Perspect. , vol.49 , pp. 107-115
    • Santella, R.M.1    Grunberger, D.2
  • 42
    • 0017194019 scopus 로고
    • Identification of the persistently bound form of the carcinogen N-acetyl-2-aminofluorene to rat liver DNA in vivo
    • Westra, J. G., Kriek, E., and Hittenhausen, H. (1976) Identification of the persistently bound form of the carcinogen N-acetyl-2-aminofluorene to rat liver DNA in vivo. Chem.-Biol. Interact. 15, 149-164.
    • (1976) Chem.-Biol. Interact. , vol.15 , pp. 149-164
    • Westra, J.G.1    Kriek, E.2    Hittenhausen, H.3
  • 43
    • 0020050583 scopus 로고
    • Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydoxy-2-acetylaminofluorene
    • Beland, F. A., Dooley, K. L., and Jackson, C. D. (1982) Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydoxy-2-acetylaminofluorene. Cancer Res. 42, 1348-1354.
    • (1982) Cancer Res. , vol.42 , pp. 1348-1354
    • Beland, F.A.1    Dooley, K.L.2    Jackson, C.D.3
  • 44
    • 0018884091 scopus 로고
    • Characterization of DNA adducts of the carcinogen N-methyl-4-aminoazobenzene in vitro and in vivo
    • Beland, F. A., Tillis, D L., Kadlubar, F. F., Straub, K. M., and Evans, F. D. (1980) Characterization of DNA adducts of the carcinogen N-methyl-4-aminoazobenzene in vitro and in vivo. Chem.-Biol. Interact. 31, 1-17.
    • (1980) Chem.-Biol. Interact. , vol.31 , pp. 1-17
    • Beland, F.A.1    Tillis, D.L.2    Kadlubar, F.F.3    Straub, K.M.4    Evans, F.D.5
  • 45
    • 0019857279 scopus 로고
    • A comparison of the carcinogen-DNA adducts formed in rat liver in vivo after administration of single or multiple doses of N-methyl-4-aminoazobenzene
    • Tillis, D. L. Straub, K. M., and Kadluabr, F. F. (1981) A comparison of the carcinogen-DNA adducts formed in rat liver in vivo after administration of single or multiple doses of N-methyl-4-aminoazobenzene. Chem.-Biol. Interact. 38, 15-27.
    • (1981) Chem.-Biol. Interact. , vol.38 , pp. 15-27
    • Tillis, D.L.1    Straub, K.M.2    Kadluabr, F.F.3
  • 46
    • 0020358778 scopus 로고
    • Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis
    • Moore, P. D., Rabkin, S. D., Osborn, A. L., King, C. M., and Strauss, B. S. (1982) Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 79, 7166-7170.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 7166-7170
    • Moore, P.D.1    Rabkin, S.D.2    Osborn, A.L.3    King, C.M.4    Strauss, B.S.5
  • 47
    • 0021873379 scopus 로고
    • DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli. A correlation between conformation of the premutagenic lesion and the mutation specificity
    • Bichara, M., and Fuchs, R. P. P. (1985) DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli. A correlation between conformation of the premutagenic lesion and the mutation specificity. J. Mol. Biol. 183, 341-351.
    • (1985) J. Mol. Biol. , vol.183 , pp. 341-351
    • Bichara, M.1    Fuchs, R.P.P.2
  • 48
    • 0024366697 scopus 로고
    • Recognition and repair of 2-aminofluorene- and 2-(acetylamino)fluorene - DNA adducts by UVRABC nuclease
    • Pierce, J. R., Case, R., and Tang, M.-S. (1989) Recognition and repair of 2-aminofluorene- and 2-(acetylamino)fluorene - DNA adducts by UVRABC nuclease. Biochemistry 28, 5821-5826.
    • (1989) Biochemistry , vol.28 , pp. 5821-5826
    • Pierce, J.R.1    Case, R.2    Tang, M.-S.3
  • 50
    • 0023944949 scopus 로고
    • Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents
    • Basu, A. K., and Essigmann, J. M. (1988) Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents. Chem. Res. Toxicol. 1, 1-18.
    • (1988) Chem. Res. Toxicol. , vol.1 , pp. 1-18
    • Basu, A.K.1    Essigmann, J.M.2
  • 51
    • 0029875810 scopus 로고    scopus 로고
    • DNA adduct formation of the food-derived mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates undergoing carcinogen bioassay
    • Turesky, R. J., Gremaud, E., Markovic, J, and Snyderwine, E. G. (1996) DNA adduct formation of the food-derived mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates undergoing carcinogen bioassay. Chem Res. Toxicol 9, 403-408.
    • (1996) Chem Res. Toxicol , vol.9 , pp. 403-408
    • Turesky, R.J.1    Gremaud, E.2    Markovic, J.3    Snyderwine, E.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.