Cactus-independent regulation of Dorsal nuclear import by the ventral signal

Current Biology

Volumn 10, Issue 1, 2000, Pages 23-26

  Drier, Eric A ^a   Govind, Shubha ^b   Steward, Ruth ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033976430     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)00267-5     Document Type: Article

References (14)

1. Ghosh S., May M.J., Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 16:1998;225-260.
2. Drier E.A., Steward R. The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila. Semin Cancer Biol. 8:1997;83-92.
3. Govind S. Control of development and immunity by Rel factors in Drosophila. Oncogene. 18:1999;6875-6887.
4. Roth S., Hiromi Y., Godt D., Nüsslein-Volhard C. cactus, a maternal gene required for proper formation for the dorsoventral morphogen gradient in Drosophila embryos. Development. 112:1991;371-388.
5. Reach M., Galindo R.L., Towb P., Allen J.L., Karin M., Wasserman S.A. A gradient of Cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev Biol. 180:1996;353-364.
6. Whalen A.M., Steward R. Dissociation of the Dorsal-Cactus complex and phosphorylation of the Dorsal protein correlate with the nuclear localization of Dorsal. J Cell Biol. 123:1993;523-534.
7. Gillespie S.K.H., Wasserman S. dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol Cell Biol. 14:1994;3559-3568.
8. Drier E.A., Huang L.H., Steward R. Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev. 13:1999;556-568.
9. Lehming N., McGuire S., Brickman J.M., Ptashne M. Interactions of a Rel protein with its inhibitor. Proc Natl Acad Sci USA. 92:1995;10242-10246.
10. Belvin M.P., Jin Y., Anderson K.V. Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev. 9:1995;783-793.
11. Bergmann A., Stein D., Geisler R., Hagenmaier S., Schmid B., Fernandez N.et al. A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. Mech Dev. 60:1996;109-123.
12. Whiteside S.T., Israël A. IκB proteins: structure, function and regulation. Semin Cancer Biol. 8:1997;75-82.
13. Huxford T., Huang D.B., Malek S., Ghosh G. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell. 95:1998;759-770.
14. Jacobs M.D., Harrison S.C. Structure of an IκBα/NF-κB complex. Cell. 95:1998;749-758.