Helicobacter pylori uptake and efflux: Basis for intrinsic susceptibility to antibiotics in vitro

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 2, 2000, Pages 248-254

  Bina, J E ^a   Alm, R A ^b   Uria Nickelsen, M ^b   Thomas, S R ^b   Trust, T J ^b   Hancock, R E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; ANTIBIOTIC AGENT; BETA LACTAMASE; CARRIER PROTEIN; CHLORAMPHENICOL; OUTER MEMBRANE PROTEIN; POLYMYXIN B; TETRACYCLINE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG UPTAKE; ESCHERICHIA COLI; HELICOBACTER PYLORI; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; STRAIN DIFFERENCE;

1-NAPHTHYLAMINE; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; CHLORAMPHENICOL; FLUORESCENT DYES; GENES, BACTERIAL; HELICOBACTER PYLORI; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS; OPERON; TETRACYCLINE; TRITIUM;

EID: 0033972068     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.2.248-254.2000     Document Type: Article

References (32)

1. Alm, R. A., L. S. Ling, D. T. Moir, B. L. King, E. D. Brown, P. C. Doig, D. R. Smith, B. Noonan, B. C. Guild, B. L. deJonge, G. Carmel, P. J. Tummino, A. Caruso, M. Uria-Nickelsen, D. M. Mills, C. Ives, R. Gibson, D. Merberg, S. D. Mills, Q. Jiang, D. E. Taylor, G. F. Vovis, and T. J. Trust. 1999. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 14:176-180.
2. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-110.
3. Amsterdam, D. 1996. Susceptibility testing of antimicrobials in liquid media, p. 52-111. In V. Lorian (ed.), Antibiotics in laboratory medicine, 4th ed. Williams and Wilkins, Baltimore, Md.
4. Bina, J. E., F. Nano, and R. E. W. Hancock. 1997. Utilization of alkaline phosphatase fusions to identify secreted proteins, including potential efflux proteins and virulence factors from Helicobacter pylori. FEMS Microbiol. Lett. 148:63-68.
5. Curtiss, N. A. C., R. L. Eisenstadt, C. Rudd, and A. J. White. 1986. Inducible type I β-lactamases of Gram negative bacteria and resistance to β-lactam antibiotics. J. Antimicrob. Chemother. 17:51-61.
6. Doig, P., M. M. Exner, R. E. W. Hancock, and T. J. Trust. 1995. Isolation and characterization of a conserved porin protein from Helicobacter pylori. J. Bacteriol. 177:5447-5452.
7. Dunn, B. C., H. Cohen, and M. J. Blaser. 1997. Helicobacter pylori. Clin. Microbiol. Rev. 10:720-741.
8. Exner, M. M., P. Doig, T. J. Trust, and R. E. W. Hancock. 1995. Isolation and characterization of a family of porin proteins from Helicobacter pylori. Infect. Immun. 63:1567-1572.
9. 8a. Felgenstein, J. 1993. PHYLIP (phylogeny inference package) version 3.5c. Department of Genetics, University of Washington, Seattle.
10. Haman, K. E., W. Pan, B. G. Spratt, J. T. Balthazar, R. C. Judd, and W. M. Shafer. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141: 611-622.
11. Hancock, R. E. W. 1997. The bacterial outer membrane as a drug barrier. Trends Microbiol. 5:37-42.
12. Huang, H., and R. E. W. Hancock. 1996. The role of specific surface loup regions in determining the function of the imipenem-specific pore protein OprD of Pseudomonas aeruginosa. J. Bacteriol. 178:3085-3090.
13. Huang, X. 1992. A contig assembly program based on sensitive detection of fragment overlaps. Genomics 14:18-25.
14. Jiang, Q., K. Hiratsuka, and D. E. Taylor. 1996. Variability of gene order in different Helicobacter pylori strains contributes to genome diversity. Mol. Microbiol. 20:833-842.
15. Kohler, T., M. Michea-Hamzehpour, U. Henze, N. Gotoh, L. K. Curty, and J. C. Pechere. 1997. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol. Microbiol. 23:345-354.
16. Labigne, A., P. Courroux, and L. Tompkins. 1992. Cloning of Campylobacter jejuni genes required for leucine biosynthesis, and construction of a leunegative mutant of C. jejuni by shuttle transposon mutagenesis. Res. Microbiol. 143:15-26.
17. Lee, A., J. O'Rourke, U. M. De, B. Robertson, G. Daskalopoulos, and M. F. Dixon. 1997. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112:1386-1397.
18. Li, X. Z., H. Nikaido, and K. Poole. 1995. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
19. Loh, B., C. Grant, and R. E. W. Hancock. 1984. Use of the fluorescent probe 1-N-phenylnapthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 26:546-551.
20. Ma, D., D. N. Cook, M. Alberti, N. G. Pon, H. Nikaido, and J. E. Hearst. 1995. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microbiol. 16:45-55.
21. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
22. McNulty, C. A., J. Dent, and R. Wise. 1985. Susceptibility of clinical isolates of Campylobacter pyloridis to 11 antimicrobial agents. Antimicrob. Agents Chemother. 28:837-838.
23. Moore, R. A., B. Beckthold, and L. E. Bryan. 1995. Metronidazole uptake in Helicobacter pylori. Can. J. Microbiol. 41:746-749.
24. Nikaido, H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
25. Ocaktan, A., H. Yoneyama, and T. Nakae. 1997. Use of fluorescence probes to monitor function of the subunit proteins of the MexA-MexB-OprM drug extrusion machinery in Pseudomonas aeruginosa. J. Biol. Chem. 272:21964-21969.
26. Paulsen, I. T., M. H. Brown, and R. A. Skurray. 1996. Proton-dependent multidrug efflux systems. Microbiol. Rev. 60:575-608.
27. Saier, M. H. M., R. Tam, A. Reizer, and J. Reizer. 1994. Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol. Microbiol. 11:841-847.
28. Sanchez, L., W. Pan, M. Vinas, and H. Nikaido. 1997. The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. J. Bacteriol. 179:6855-6857.
29. Scott, M., H. Yan, and R. E. W. Hancock. 1999. Biological properties of structurally related cationic antimicrobial peptides. Infect. Immun. 67:2006-2009.
30. Staskawicz, B., D. Dahlbeck, N. Keen, and C. Napoli. 1987. Molecular characterization of cloned avirulence genes from race 0 and race 1 of Pseudomonas syringae pv. glycinea. J. Bacteriol. 169:5789-5794.
31. Tomb, J. F., O. White, A. R. Kerlavage, R. A. Clayton, G. G. Simon, R. D. Fleischmann, K. A. Ketchum, H. P. Klenk, S. Gill, B. A. Dougherty, K. Nelson, J. Quackenbush, L. Zhou, E. F. Kirkness, S. Peterson, B. Loftus, D. Richardson, R. Dodson, H. G. Khalak, A. Glodek, K. McKenney, L. M. Fitzgerald, N. Lee, M. D. Adams, and J. C. Venter. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-547.
32. van der Hulst, R. W., J. J. Keller, E. A. Rauws, and G. N. Tytgat. 1996. Treatment of Helicobacter pylori infection: a review of the world literature. Helicobacter 1:6-19.