IL-12 is produced by antigen-presenting cells stimulated with soluble αβ TCR and restores impaired T(h)1 responses

International Immunology

Volumn 12, Issue 1, 2000, Pages 103-112

  Kawamoto, Keiko ^a   Paliwal, Vipin ^b   Ramabhadran, Rajani ^b   Szczepanik, Marian ^c   Tsuji, Ryohei F ^d   Matsuda, Hiroshi ^e   Askenase, Philip W ^b  

^a Osaka Prefecture University   (Japan)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d Noda Institute for Scientific Research   (Japan)

^e TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Contact sensitivity; Delayed type hypersensitivity; T cell suppression

Indexed keywords

ANTIBODY; GAMMA INTERFERON; HAPTEN; INTERLEUKIN 12; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CELL FUNCTION; CONTACT SENSITIVITY; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SUPERNATANT; T LYMPHOCYTE; TH1 CELL;

EID: 0033971484     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.1.103     Document Type: Article

References (47)

1. Vadas, M. A. and Greene, M. I. 1981. Role of the MHC in delayed-type hypersensitivity. In Dorf, M. E., ed., The Role of Major Histocompatibility Complex in Immunobiology, p. 271. Garland, New York.
2. -) and CD3 negative; and expresses IL-3 receptors, but no IL-2 receptors. J. Immunol. 143:3125.
3. d-restricted TNP epitopes. J. Immunol. 151:678.
4. Streilein, J. W., Lonsberry, L. W. and Bergstresser, P. R. 1982. Depletion of epidermal Langerhans cells and la immunogenicity from tape-stripped mouse skin. J. Exp. Med. 155:863.
5. Aiba, S. and Katz, S. I. 1990. Phenotypic and functional characteristics of in vivo activated Langerhans cells. J. Immunol. 145:2791.
6. + T cell populations that mediate delayed-type hypersensitivity. J. Immunol. 133:2404.
7. h1 clones. J. Immunol. 143:2887.
8. Piguet, P. F., Grau, G. E., Hauser, C. and Vassalli, P. 1991. Tumor necrosis factor is a critical mediator in hapten-induced irritant and contact hypersensitivity reactions. J. Exp. Med. 173:673.
9. Ptak, W., Bereta, M., Marcinkiewicz, J., Gershon, R. K. and Green, D. R. 1984. Production of antigen-specific contrasuppressor cells and factor, and their use in augmentation of cell-mediated immunity. J. Immunol. 133:623.
10. Ptak, W., Bereta, M., Ptak, M., Gershon, R. and Green, D. R. 1984. Antigen-specific T contrasuppressor factor in cell-mediated immunity: interaction leading to eradication of the tolerant state J. Immunol. 133:1124.
11. Paliwal, V., Friedman, A. M., Ptak, W. and Askenase, P. W. 1994. Monoclonal, antigen-specific, T cell contrasuppressor factor expresses determinants of TCR a-chain (not necessarily TCR β-chain), having a molecular mass of about 40 kDa. J. Immunol. 152:2811.
12. Paliwal, V., Ptak, W. and Askenase, P. W. 1995. Regulation of allergic contact sensitivity in mice: soluble αβ T cell receptors, derived via cDNA transfection and enzymatic cleavage from surface of T cells, protect contact sensitivity effector T cells from active T cell suppression. Int. Arch. Allergy. Immunol. 107:365.
13. Paliwal, V., Ptak, W., Sperl, J., Braswell, E. and Askenase, P. W. 1997. Recombinant soluble T cell receptors protect T cells from immune suppression. Requirement for aggregated multimeric, disulfide-linked αβ heterodimers. J. Immunol. 159:1718.
14. Kuchroo, V. K., Steele, J. K., O'Hara, R. M., Jayaraman, S., Selvaraj, P., Greenfield, E., Kubo, R. T. and Dorf, M. E. 1990. Relationships between antigen-specific helper and inducer suppressor T cell hybridomas. J. Immunol. 145:438.
15. Fresno, M., Nabel, G., McVay-Boudreau, L. Furthmeyer, H. and Cantor, H. 1981. Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressor activity. J. Exp. Med. 153:1246.
16. Bissonnette, R., Zheng, H. G., Kubo, R. T., Singh, B. and Green, D. R. 1991. A T helper cell hybridoma produces an antigen-specific regulatory activity: relationship to the T cell receptor by serology and antigenic line specificity. J. Immunol. 146:2898.
17. Fairchild, R. L., Kubo, R. T. and Moorhead, J. W. 1988. Soluble factors in tolerance and contact sensitivity to DNFB in mice. IX. A monoclonal T cell suppressor molecule is structurally and serologically related to the α/β T cell receptor. J. Immunol. 141:3342.
18. Barbo, J. V., McCormack, J. E., Moorhead, J. W. and Fairchild, R. L. 1995. Reconstitution of TCR α-chain expression in deletion mutants restores dinitrophenyl-specific/class I MHC-restricted suppressor molecule production. J. Immunol. 154:1551.
19. Wang, Y., O'Rourke, J. and Cone, R. E. 1996. Serum TABM produced during anterior chamber-associated immune deviation passively transfers suppression of delayed-type hypersensitivity to primed mice. 1996. Int. Immunol. 9:211.
20. Griffith, T. S., Herndon, J. M., Lima, J., Kahn, M. and Ferguson, T. A. 1995. The immune response and the eye. TCR alpha-chain related molecules regulate the systemic immunity to antigen presented in the eye. Int. Immunol. 10:1617.
21. O'Hara, R. M., Jr, Byrne, M. C., Kuchroo, V. K., Nagelin, A., Whitters, M. J., Jayaraman, S., Henderson, S. L., Dorf, M. E. and Collins, M. 1995. T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction. J. Immunol. 10:1617.
22. Kubo, R. T., Born, W., Kappler, J. W., Marrack, P. and Pigeon, M. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736.
23. Slanetz, A. E. and Bothwell, A. L. 1991. Heterodimeric disulfidelinked αβ T cell receptor in solution. Eur. J. Immunol. 21:179.
24. Sperl, J., Paliwal, V., Ramabhadran, R., Nowak, B. and Askenase, P. W. 1995. Soluble T cell receptors: detection and quantitative assay in fluid phase via ELISA or immuno-PCR. J. Immunol. Methods 186:181.
25. Bender, A., Sprenger, H., Gong, J. H., Henke, A., Bolte, A. Sprengler, H. P., Nain, M. and Gemasa, D. 1993. The potentiating effects of LPS on TNFa production by influenza A virus infected macrophages. Immunobiology 187:357.
26. H1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
27. h cells. J. Exp. Med. 177:1199.
28. + T cells to enhance priming for IFN-y production and diminishes interleukin 4 inhibition of such priming. Pfoc. Natl Acad. Sci. USA 90:10188.
29. Muller, G., Saloga, J., Germann, T., Schuler, G., Knop, J. and Enk, A. H. 1996. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo J. Immunol. 155:4661.
30. Riemann, H., Schwartz, A., Grabbe, S., Aragane, Y., Lugar, T. A., Wysocka, M., Kubin, M., Trinchieri, G. and Schwartz, T. 1996. Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance. J. Immunol. 156:1799.
31. Gazzinelli, R. T, Giese, N. A. and Morse, H. C. 1994, In vivo treatment with IL-12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS). J. Exp. Med. 180:2199.
32. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E. and Gately, M. K. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
33. Murray, H. W. and Hariprashad, J. 1995 Interleukin 12 is effective treatment for an established systemic intracellular infectioh: experimental visceral leishmaniasis. J. Exp. Med. 181:387.
34. Schmitt, D. A., Owen-Schaub, L. and Ullrich, S. E. 1995. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J. Immunol. 154:5114.
35. Ushio, H., Tsuji, R. F., Szczepanik, M., Kawamoto, K., Matsuda, H. and Askenase, P. W. 1998. IL-12 reverses established antigen-specific tolerance of contact sensitivity by affecting costimulatory molecules B7-1 (CD80) and B7-2 (CD86) J. Immunol. 160:2080.
36. Murphy E. E., Terres, G., Macantonia, S. E., Hsieh, C., Mattson, J., Lanier, L., Wysocka, M., Trinchieri, G., Murphy, K. and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
37. Kang, K., Kubin, M., Cooper, K. D., Lessin, S. R., Trinchieri, G. and Rook, A. H. . 1996. lL-12 synthesis by human Langerhans cells. J. Immunol. 156:1402.
38. + T cells. J. Immunol. 154:5071.
39. Benjamin, D., Sharma, V., Kubin, M., Klein, J. L., Sartori, A., Holliday, J. and Trinchieri, G. 1996. IL-12 expression in AIDS-related lymphoma B cell lines. J. Immunol. 156:1626.
40. Muller, G., Saltoga, J., Germann, T., Bellinghausen, I., Mohamadzadeh, M., Krop, J. and Enk, A. H. 1994. Identification and induction of human keratinocyte-derived IL-12, J. Clin. Invest. 94:1799.
41. Demaria, S., Schwab, R., Gottesman, S. R. and Bushkin, Y. 1994. Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease. J. Biol. Chem. 269:6689.
42. Peakman, M., Senaldi, G., Foote, N , McManns, T. J. and Vergani, D. 1992. Naturally occurring soluble CD4 in patients with human immunodeficiency virus infection. J. Infect. Diseases. 165:799.
43. Linker-Israeli, M., Hyun, S., Ozeri-Chen, T., Wallace, D. J., Banks, K. and Klinenberg, R. 1994. Elevated in vivo and in vitro secretion of CD8-alpha molecules in patients with systemic lupus erythematosus. J. Immunol. 152:3158.
44. Bazil, V. 1995. Physiological enzymatic cleavage of leukocyte membrane molecules. Immunol. Today. 16:135.
45. Yang, C. W., Kim, T. G., Kim, Y. S., Han, H., Chang, Y. S., Yoon, Y. S. and Bang, B. K. 1995. Serum soluble HLA class I antigen levels in hemodialysis patients and following renal transplantation. Am. J. Nephrol. 15:290.
46. Puppo, F., Picciotto, A., Brenci, S., Varagona, G., Scudeletti, M., Ghio, M., Balestra, V., Celle, G. and Indiveri, F. 1995. Behavior of soluble HLA class I antigens in patients with chronic hepatitis C during interferon therapy: an early predictor marker of response? J. Clin. Immunol. 15:179.
47. Ishizaka, S., Kimoto, M., Nishiyama, T. and Araki, T. 1995. Detection of soluble T cell receptor-releasing cells by ELISPOT assay. J. Immunoassay 16:97.