Aminoacyl-tRNA and tissue free amino acids pools are equilibrated after a flooding dose of phenylalanine

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 1 40-1, 1999, Pages

  Davis, Teresa A ^a   Fiorotto, Marta L ^a   Nguyen, Hanh V ^a   Burrin, Douglas G ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Insulin; Liver; Protein synthesis; Skeletal muscle

Indexed keywords

AMINOACYL TRANSFER RNA; INSULIN; PHENYLALANINE;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; FEMALE; HYPERINSULINEMIA; LIVER METABOLISM; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS REGULATION; SKELETAL MUSCLE; SWINE; TISSUE DISTRIBUTION;

EID: 0032783115     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.1.e103     Document Type: Article

References (37)

1. Attaix, D., E. Aurousseau, G. Bayle, D. Rosolowska-Huszca, and M. Arnal. Respective influences of age and weaning on skeletal and visceral muscle protein synthesis in the lamb. Biochem. J. 256: 791-795, 1988.
2. Bailie, A. G. S., and P. J. Garlick. Attenuated responses of muscle protein synthesis to fasting and insulin in adult female rats. Am. J. Physiol. E262 (Endocrinol. Metab. 25): E1-E5, 1991.
3. Barnes, D. M., C. C. Calvert, and K. C. Klasing. Source of amino acids for tRNA acylation. Biochem. J. 283: 583-589, 1992.
4. Barnes, D. M., C. C. Calvert, and K. C. Klasing. Source of amino acids for tRNA acylation in growing chicks. Amino Acids 7: 267-278, 1994.
5. Baumann, P. Q., W. S. Stirewalt, B. D. O'Rourke, D. Howard, and K. S. Nair. Precursor pools of protein synthesis: a stable isotope study in a swine model. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E203-E209, 1994.
6. Beckett, P. R., D. S. Hardin, T. A. Davis, H. V. Nguyen, D. Wray-Cahen, and K. C. Copeland. Spectrophometric assay for measuring branched chain amino acid concentrations: application for measuring the sensitivity of protein metabolism to insulin. Anal. Biochem. 240: 48-53, 1996.
7. Biolo, G., R. Y. D. Fleming, and R. R. Wolfe. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J. Clin. Invest. 95: 811-819, 1995.
8. Boirie, J., P. Gachon, and B. Beaufrere. Splanchnic and whole-body leucine kinetics in young and elderly men. Am. J. Clin. Nutr. 65: 489-495, 1997.
9. Bylund-Fellenius, A.-Q., K. M. Ojamaa, K. E. Flaim, J. B. Li, S. J. Wassner, and L. S. Jefferson. Protein synthesis versus energy state in contracting muscles of perfused rat hindlimb. Am. J. Physiol. 246 (Endocrinol. Metab. 9): E297-E305, 1984.
10. Davis, T. A., D. G. Burrin, M. L. Fiorotto, and H. V. Nguyen. Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7- and 26-day-old pigs. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E802-E809, 1996.
11. Davis, T. A., M. L. Fiorotto, H. V. Nguyen, and P. J. Reeds. Protein turnover in skeletal muscle of suckling rats. Am. J. Physiol. 257 (Regulatory Integrative Comp. Physiol. 26): R1141-R1146, 1989.
12. Davis, T. A., M. L. Fiorotto, H. V. Nguyen, and P. J. Reeds. Enhanced response of muscle protein synthesis and plasma insulin to food intake in suckled rats. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R334-R340, 1993.
13. Denne, S. C., E. A. Liechty, Y. M. Liu, G. Brechtel, and A. D. Baron. Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E809-E814, 1991.
14. Dunlop, D. S., X. Yang, and A. Lajtha. The effect of elevated plasma phenylalanine levels on protein synthesis rates in adult rat brain. Biochem. J. 301: 601-610, 1994.
15. Farrell, R. E. RNA Methodologies. San Diego: Academic, 1993.
16. Garlick, P. J., M. Fern, and V. R. Preedy. The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats. Biochem. J. 210: 669-676, 1983.
17. Garlick, P. J., M. A. McNurlan, P. Essén, and J. Wernerman. Measurement of tissue protein synthesis rates in vivo: a critical analysis of contrasting methods. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E287-E297, 1994.
18. 3H]phenylalanine. Biochem. J. 192: 719-723, 1980.
19. Heslin, M. J., E. Newman, R. F. Wolf, P. W. T. Pisters, and M. F. Brennan. Effect of hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E911-E918, 1992.
20. Karim, M. A., A. G. Ferguson, B. T. Wakim, and A. M. Samarel. In vivo collagen turnover during development of thyroxine-induced left ventricular hypertrophy. Am. J. Physiol. 260 (Cell Physiol. 29): C316-C326, 1991.
21. Ljungqvist, O. H., M. Persson, G. C. Ford, and K. S. Nair. Functional heterogeneity of leucine pools in human skeletal muscle. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E564-E570, 1997.
22. Louard, R. J., D. A. Fryburg, R. A. Gelfand, and E. J. Barrett. Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle. J. Clin. Invest. 90: 2348-2354, 1992.
23. Martin, A. F., M. Rabinowitz, R. Blough, G. Prior, and R. Zak. Measurements of half-life of rat cardiac myosin heavy chain with leucyl-tRNA used as precursor pool. J. Biol. Chem. 252: 3422-3429, 1977.
24. McKee, E. E., J. Y. Cheung, D. E. Rannels, and H. E. Morgan. Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine. J. Biol. Chem. 253: 1030-1040, 1978.
25. 13C]leucine infusion. Metabolism 38: 248-255, 1989.
26. Reeds, P. J., P. Haggarty, K. W. J. Wahle, and J. M. Fletcher. Tissue and whole body protein synthesis in immature Zucker rats and their relationship to protein deposition. Biochem. J. 204: 393-398, 1982.
27. Rennie, M. J., R. H. T. Edwards, D. Halliday, D. E. Matthews, S. L. Wolman, and D. J. Millward. Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting. Clin. Sci. (Colch.) 63: 519-523, 1982.
28. Robinson, M. E., and A. M. Samarel. Regional differences in in vivo myocardial protein synthesis in the neonatal rabbit heart. J. Mol. Cell. Cardiol. 22: 607-618, 1990.
29. Samarel, A. M. In vivo measurements of protein turnover during muscle growth and atrophy. FASEB J. 5: 2020-2028, 1991.
30. Smith, C. B., and Y. Sun. Influence of valine flooding on channeling of valine into tissue pools and on protein synthesis. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E735-E744, 1995.
31. Snedecor, G. W., and W. G. Cochran. Statistical Methods. Ames, Iowa: Iowa State Univ. Press, 1967.
32. Stirewalt, W. S., and R. B. Low. Effects of insulin in vitro on protein turnover in rat epitrochlearis muscle. Biochem. J. 210: 323-330, 1983.
33. Tessari, P., M. Zanetti, R. Barazzoni, M. Vettore, and F. Michielan. Mechanisms of postprandial protein accretion in human skeletal muscle. J. Clin. Invest. 98: 1361-1372, 1996.
34. Watt, P. W., Y. Lindsay, C. M. Scrimgeour, P. A. F. Chien, J. N. A. Gibson, D. J. Taylor, and M. J. Rennie. Isolation of aminoacyl-tRNA and its labeling with stable-isotope tracers: use in studies of human tissue protein synthesis. Proc. Natl. Acad. Sci. USA 88: 5892-5896, 1991.
35. Wray-Cahen, D., P. R. Beckett, H. V. Nguyen, and T. A. Davis. Insulin-stimulated amino acid utilization during glucose and amino acid clamps decreases with development. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E305-E314, 1997.
36. Wray-Cahen, D., H. V. Nguyen, D. G. Burrin, P. R. Beckett, M. L. Fiorotto, P. J. Reeds, T. J. Wester, and T. A. Davis. Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E602-E609, 1998.
37. Young, L. H., W. Stirewalt, P. H. McNulty, J. H. Revkin, and E. J. Barrett. Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E337-E342, 1994.