Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies

Current Eye Research

Volumn 20, Issue 2, 2000, Pages 109-114

  Kitaichi, Nobuyoshi ^a   Matsuda, Akira ^a   Kotake, Satoshi ^a   Namba, Kenichi ^a   Tagawa, Yoshitsugu ^a   Sasamoto, Yoichi ^a   Ogasawara, Kazumasa ^b   Iwabuchi, Kazuya ^b   Onoé, Kazunori ^b   Matsuda, Hidehiko ^a   Nishihira, Jun ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Anti MIF monoclonal antibody; Experimental autoimmune uveoretinitis (EAU); Macrophage migration inhibitory factor (MIF); Rats

Indexed keywords

IMMUNOGLOBULIN M; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; RETINOID BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; T LYMPHOCYTE; UVEORETINITIS;

EID: 0033968153     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/0271-3683(200002)2021-DFT109     Document Type: Article

References (30)

1. Faure JP. Autoimmunity and the retina. Curr Top Eye Res. 1980;2:215-302.
2. Gery I, Mochizuki M, Nussenblatt RB. Retinal specific antigens and immunopathogenic processes they provoke. Prog Retinal Res. 1986;5:75-109.
3. Rizzo LV, Silver P, Wiggert B, Hakim F, Gazzinelli RT, Chan CC, Caspi RR. Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice. J Immunol. 1996;156:1654-1660.
4. Caspi RR, Sun B, Agarwal RK, Silver PB, Rizzo LV, Chan C, Wiggert B, Wilder RL. T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile. Eye 1997;11:209-212.
5. Mochizuki M, Kuwabara T, McAllister C, Nussenblatt RB, Gery I. Adoptive transfer of experimental autoimmune uveoretinitis in rats Immunopathogenic mechanisms and histologic features. Invest Ophthalmol Vis Sci. 1985;26:1-9.
6. Caspi RR, Roberge FG, MacAllister CG. ElSaied M, Kuwabara T, Gery I, Hanna E, Nussenblatt RB. T-cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J Immunol. 1986;136:928-933.
7. Gregerson DS, Obritsch WF, Fling SP, Cameron JD. S-antigen specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. J Immunol. 1986;136:2875-2882.
8. Atalla L, Linker-Israeli M, Steinman L, Rao NA. Inhibition of autoimmune uveitis by anti-CD4 antibody. Invest Ophthalmol Vis Sci. 1990;31:1264-1270.
9. Bloom BR, Bennet B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966;153:80-82.
10. Bernhagen J, Bacher M, Calandra T, Metz CN, Doty SB, Donnelly T, Bucala R. An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction. J Exp Med. 1996;183:277-282.
11. Bernhagen J, Calandra T, Mitchell RA, Martin SB, Tracy KJ, Voelter W, Manogue KR, Cerami A, Bucala R. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature. 1993;365:756-759.
12. Calandra T, Bernhagen J, Metz CN, Spiegel LA, Bacher M, Donnelly T, Cerami A, Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 1995;376:68-71.
13. Bacher M, Metz CN, Calandra T, Mayer K, Chesney J, Lohoff M, Gemsa D, Donnelly T, Bucala R. An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci USA. 1996;93:7849-7854.
14. Lan HY, Bacher M, Yang N, Mu W, Nikolic-Paterson DJ, Metz C, Meinhardt A, Bucala R, Atkins RC. The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat. J Exp Med. 1997;185:1455-1465.
15. Mikulowska A, Metz CN, Bucala R, Holmdahl R. Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice. J Immunol. 1997;158:5514-5517.
16. Matsuda A, Tagawa Y, Yoshida K, Matsuda H, Nishihira J. Expression of macrophage migration inhibitory factor in rat retina and its immunohistochemical localization. J Neuroimmunol. 1997;77:85-90.
17. Kitaichi N, Kotake S, Sasamoto Y, Namba K, Matsuda A, Ogasawara K, Onoé K, Matsuda H, Nishihira J. Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis. Invest Ophthalmol Vis Sci. 1999;40:247-250.
18. Weiser WY, Temple PA, Witek-Giannotti JS, Remold HG, Clark SC, David JR. Molecular cloning of cDNA encoding a human macrophage migration inhibitory factor. Proc Natl Acad Sci USA. 1989;86:7522-7526.
19. Sugimoto H, Suzuki M, Nakagawa A, Tanaka I, Nishihira J. Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1Å- resolution. FEBS Lett. 1996;389:145-148.
20. Kitaichi N, Ogasawara K, Iwabuchi K, Nishihira J, Namba K, Onoé K Jr., Konishi J, Kotake S, Matsuda H, Onoé K. Different influence of macrophage migration inhibitory factor (MIF) in signal transduction pathway of various T cell subsets. Immunobiology: in press.
21. Sasamoto Y, Kawano Y, Wiggert B, Chader GJ, Gery I. Induction of unresponsiveness in adult rats by immunodominant and nondominant peptides. Cell Immunol. 1993;152:286-292.
22. Kotake S, Sasamoto Y, Kawano Y, Sanui H, Wiggert B, Chader GJ, Gery I. The existence of two completely distinct antigenic sites within a decapeptide. Cell Immunol. 1992;140:123-129.
23. Sasamoto Y, Kawano Y, Boulingny R, Wiggert B, Chader GJ, Gery I. Immunomodulation of experimental autoimmune uveoretinitis by intravenous injection of uveitogenic peptides. Invest Ophthalmol Vis Sci. 1992;33: 2641-2649.
24. Sasamoto Y, Kotake S, Yoshikawa K, Wiggert B, Gery I, Matsuda H. Interphotoreceptor retinoid-binding protein derived peptide can induce experimental autoimmune uveoretinitis in various rat strains. Curr Eye Res. 1994;13:845-849.
25. Caspi RR, Silver PB, Chan C, Sun B, Agarwal RK, Wells J, Oddo S, Fujino Y, Najafian F, Wilder RL. Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J Immunol. 1996;157:2668-2675.
26. Gery I, Wiggert B, Redmond TM, Kuwabara T, Crawford MA, Vistica BP, Chader GJ. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest Ophthalmol Vis Sci. 1986; 27:1296-1300.
27. Kotake S, Smet MD, Wiggert B, Redmond TM, Chader GJ, Gery I. Analysis of the pivotal residues of the immunodominant and highly uveitogenic determinant of interphotoreceptor retinoid-binding protein. J Immunol 1991;146:2995-3001.
28. Takahashi A, Iwabuchi K, Suzuki M, Ogasawara K, Nishihira J, Onoé K. Antisense macrophage migration inhibitory factor (MIF) prevents anti-IgM mediated growth arrest and apoptosis of a murine B cell line by regulating cell cycle progression. Microbiol Immunol. 1999;43:61-67.
29. Namba K, Ogasawara K, Kitaichi N, Matsuki N, Takahashi A, Sasamoto Y, Kotake S, Matsuda H, Iwabuchi K, Ohno S, Onoé K. Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2k-carrying mice. Clin Exp Immunol. 1998;111:442-449.
30. Calandra T, Bernhagen J, Mitchell RA, Bucala R. The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J Exp Med. 1994;179:1895-1902.