Leg ulcers in patients with myeloproliferative disorders: Disease- or treatment-related?

Dermatology

Volumn 200, Issue 1, 2000, Pages 45-48

  Bader, Urs ^a,b   Banyai, M ^b   Boni R ^a   Burg, G ^a   Hafner, J ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Hydroxyurea; Leg ulcer; Myeloproliferative disorder

Indexed keywords

HYDROXYUREA;

AGED; ARTICLE; CASE REPORT; CRYOGLOBULINEMIA; DRUG WITHDRAWAL; FEMALE; HUMAN; LEG ULCER; MALE; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; PYODERMA; VASCULITIS; WOUND HEALING;

EID: 0033966724     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000018315     Document Type: Article

References (33)

1. Stahl RL, Silber R: Vasculitic leg ulcers in chronic myelogenous leukemia. Am J Med 1985;78:869-872.
2. Phillips TJ, Dover JS: Leg ulcers (see comments). J Am Acad Dermatol 1991;25:965-987.
3. Cox NH, White SI, Walton S, Wyatt EH, Morley WN: Pyoderma gangrenosum associated with polycythaemia rubra vera. Clin Exp Dermatol 1987;12:375-377.
4. Ho KK, Otridge BW, Vandenberg E, Powell FC: Pyoderma gangrenosum, polycythemia rubra vera, and the development of leukemia. J Am Acad Dermatol 1992;27:804-808.
5. Ko CB, Walton S, Wyatt EH: Pyoderma gangrenosum: Associations revisited. Int J Dermatol 1992;31:574-577.
6. Lewis SJ, Poh Fitzpatrick MB, Walther RR: Atypical pyoderma gangrenosum with leukemia. JAMA 1978;239:935-938.
7. Caughman W, Stern R, Haynes H: Neutrophilic dermatosis of myeloproliferative disorders: Atypical forms of pyoderma gangrenosum and Sweet's syndrome associated with myeloproliferative disorders. J Am Acad Dermatol 1983;9: 751-758.
8. Helm KF, Peters MS,Tefferi A, Leiferman KM: Pyoderma gangrenosum-like ulcer in a patient with large granular lymphocytic leukemia. J Am Acad Dermatol 1992;27:868-871.
9. Cortelazzo S, Finazzi G, Ruggeri M, Vestri O, Galli M, Rodeghiero F, Barhui T: Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis (see comments). N Engl J Med 1995;332:1132-1136.
10. Najean Y, Rain JD: Treatment of polycythemia vera: The use of hydroxyureu and pipobroman in 292 patients under the age of 65 years. Blood 1997;90:3370-3377.
11. Tetteri A. Elliott MA, Solberg LA Jr, Silverstein MN: New drugs in essential thrombocythemia and polycythemia vera. Blood Rev 1997;11:1-7.
12. Nguyen TV, Margolis DJ: Hydroxyurea and lower leg ulcers. Cutis 1993;52:217-219.
13. Best PJ, Daoud MS, Pittelkow MR, Petitt RM: Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med 1998;128:29-32.
14. Weinlich G, Schuler G, Greil R, Kofler H, Fritsch P: Leg ulcers associated with long-term hydroxyurea therapy. J Am Acad Dermatol 1998;39:372-374.
15. Daoud MS, Gibson LE, Pittelkow MR: Hydroxyurea dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyurea. J Am Acad Dermatol 1997;36:178-182.
16. Sigal M, Crickx B, Blanchet P, Perron J, Simony J, Belaich S: Cutaneous lesions induced by long-term use of hydroxyurea. Ann Dermatol Vénéréol 1984;111:895-900.
17. Richard M, Truchetet F, Friedel J, Leclech C, Heid E: Skin lesions simulating chronic dermatomyositis during long-term hydroxyurea therapy. J Am Acad Dermatol 1989;21:797-799.
18. Kennedy BJ, Smith LR, Goltz RW: Skin changes secondary to hydroxyurea therapy. Arch Dermatol 1975;111:183-187.
19. Masuoka H, Kobayashi M, Kaito K, Yoshida M, Sekita T, Saeki A, Nishiwaki K, Shimada T, Ochiai S, Ootsubo H, et al: Bilateral ankle ulcers associated with hydroxyurea therapy for chronic myclogenous leukemia. Rinsho Ketsueki 1995;36:156-158.
20. Esteve E, Roger M, Nguyen P, Kalis B: A case for diagnosis: Ulceration of the skin caused by hydrea. Ann Dermatol Vénéréol 1996;123: 271-272.
21. Iwama H, Kawakubo K, Nehashi Y, Kuriyama Y, Iwase O, Ohyashiki K, Watanabe K, Ebihara Y, Toyama K: A lower-leg ulcer during hydroxyurea therapy for essential thrombocythemia. Gan To Kagaku Ryoho 1996;23:937-939.
22. Cox C, Nowicky D, Young R: Hydroxyurea-related ankle ulcers in patients with myeloproliferative disorders: A case report and review of the literature. Ann Plast Surg 1997;39:546-549.
23. Tomiyama J, Yano K, Uchino S, Ito T, Kudo H, Irimajiri J, Ohkubo H, Kanazawa A, Kawahara Y: Bilateral leg ulcers with pathologic evidence of small vessel vasculitis by skin biopsy during hydroxyurea therapy of chronic myelogenous leukemia. Rinsho Ketsueki 1997;38:231-233.
24. Jahn M, Zonnchen B, Kopcke W, Hehlmann R: Clinical characterization of essential thrombocythemia in comparison with other myeloproliferative diseases and reactive thrombocytoses. Klin Wochenschr 1988;66:190-198.
25. Hehlmann R, Jahn M, Baumann B, Kopeke W: Essential thrombocythemia: Clinical characteristics and course of 61 cases. Cancer 1988;61: 2487-2496.
26. Wirth K, Schoepf E, Mertelsmann R, Lindemann A: Leg ulceration with associated thrombocytosis: Healing of ulceration associated with treatment of the raised platelet count. Br J Dermatol 1998;138:533-535.
27. Varma S, Lanigan SW: Leg ulceration with associated thrombocytosis: Healing of ulceration associated with treatment of the raised platelet count (letter). Br J Dermatol 1999;140: 168-192.
28. 1 and pentoxyfilline (letter). Br J Dermatol 1998;139:1124-1126.
29. Montefusco E, Alimena G, Gastaldi R, Carlesimo OA, Valesini G, Mandelli F: Unusual dermatologic toxicity of long-term therapy with hydroxyurea in chronic myelogenous leukemia. Tumori 1986;72:317-321.
30. Yarbro JW: Mechanism of action of hydroxyurea. Semin Oncol 1992;19:1-10.
31. Ruiz-Argüelles G, Ruiz-Delgado G, Ruiz-Reyes G, Chernoff SG: Anagrelide-induced relapse of a hydroxyurea-induced leg ulcer in a patient with primary thrombocythemia (letter). Mayo Clin Proc 1998;73:1125.
32. Greer JM, Longley S, Edwards NL, Elfenbein GJ, Panush RS: Vasculitis associated with malignancy: Experience with 13 patients and literature review. Medicine (Baltimore) 1988; 67:220-230.
33. Kanel KT, Kroboth FJ, Swartz WM: Pyoderma gangrenosum with myelofibrosis. Am J Med 1987;82:1031-1034.