Macrophage migration inhibitory factor (MIF) as a paracrine mediator in the interaction of testicular somatic cells

Andrologia

Volumn 32, Issue 1, 2000, Pages 46-48

  Meinhardt, Andreas ^a,b   Bacher, M ^b   Wennemuth, G ^a   Eickhoff, R ^a   Hedger, M ^c  

^a Dept of Anatomy and Cell Biology ^*

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Compensatory production; Leydig cells; MIF; Sertoli cells; Testis

Indexed keywords

ACTIVIN; FOLLISTATIN; INHIBIN; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; CELL INTERACTION; CONFERENCE PAPER; CONTROLLED STUDY; LEYDIG CELL; MOLECULAR INTERACTION; NONHUMAN; PARACRINE SIGNALING; RAT; SEMINIFEROUS TUBULE; SOMATIC CELL; TESTIS CELL; TISSUE DISTRIBUTION;

ANIMALS; LEYDIG CELLS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; PARACRINE COMMUNICATION; RATS; SERTOLI CELLS; TESTIS;

EID: 0033966702     PISSN: 03034569     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. Bacher M, Meinhardt A, Lan HY, Mu W, Metz CN, Chesney JA, Calandra T, Gemsa D, Donnelly T, Atkins RC, Bucala R (1997) MIF expression in experimentally-induced endotoxemia. Am J Pathol 150:235-246.
2. Bernhagen J, Calandra T, Mitchell RA, Martin SB, Tracey KJ, Voelter W, Manogue KR, Cerami A, Bucala R (1993) MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature 365:756-759.
3. Bozza M, Satoskar AR, Lin G, Lu B, Humbles AA, Gerard C, David JR (1999) Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med 189:341-346.
4. David J (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Nat Acad Sci 56:72-77.
5. Donnelly SC, Bucala R (1997) Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol Med Today 3:502-507.
6. Gaytan F, Bellido C, Romero JL, Morales C, Reymundo C, Aguilar E (1994) Decreased number and size and the defective function of testicular macrophages in long-term hypophysectomized rats are reversed by treatment with human gonadotrophins. J Endocrinol 140:399-407.
7. Hedger MP (1997) Testicular leukocytes: what are they doing? Rev Reprod 2:38-47.
8. Hutson JC (1998) Interactions between testicular macrophages and Leydig cells. J Androl 19:394-398.
9. Kleemann R, Kapurniotu A, Frank RW, Gessner A, Mischke R, Flieger O, Jüttner S, Brunner H, Bernhagen J (1998) Disulfide analysis reveals a role of macrophage migration inhibitory factor (MIF) as thiol-protein oxidoreductase. J Mol Biol 280:85-102.
10. Meinhardt A, Bacher M, McFarlane JR, Metz CN, Seitz J, Hedger MP, de Kretser DM, Bucala R (1996) The macrophage migration inhibitory factor (MIF) production by Leydig cells: evidence for a role in regulation of testicular function. Endocrinology 137:5090-5095.
11. Meinhardt A, Bacher M, O'Bryan MK, McFarlane JR, Mallidis C, Lehmann C, Metz CN, de Kretser DM, Bucala R, Hedger MP (1999) A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment. J Cell Sci 112:1337-1344.
12. Nishihira J (1998) Novel pathophysilogical spects of macrophage mirgation inhibitory factor (review). Int J Mol Med 2:17-28.
13. Pescovitz OH, Srivastava CH, Breyer PR, Monts BA (1994) Paracrine control of spermatogenesis. Trends Endocr Metabol 5:126-131.
14. Rosengren E, Aman P, Thelin S, Hansson C, Ahlfors S, Bjork P, Jacobsson L, Rorsman H (1997) The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase. FEBS Lett 3:85-88.
15. Schlatt S, Meinhardt A, Nieschlag E (1997) Paracrine regulation of cellular interactions in the testis: factors in search of a function. Eur J Endocrinol 137:107-117.
16. Simpson BJB, Hedger MP, de Kretser DM (1992) Characterization of adult Sertoli cell cultures from cryptorchid rats: inhibin secretion in response to follicle-stimulating hormone stimulation. Mol Cell Endocrinol 87:167-177.
17. Wang J, Wreford NGM, Lan HY, Atkins R, Hedger MP (1994) Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol Reprod 51:551-561.