A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment

Journal of Cell Science

Volumn 112, Issue 9, 1999, Pages 1337-1344

  Meinhardt, Andreas ^a,b   Bacher, Michael ^b   O'Bryan, Moira K ^a   McFarlane, James R ^a,d   Mallidis, Con ^a   Lehmann, Christof ^b   Metz, Christine N ^c   De Kretser, David M ^a   Bucala, Richard ^c   Hedger, Mark P ^a  

^a MONASH UNIVERSITY   (Australia)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c PICOWER INST FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

EDS; MIF; Testis

Indexed keywords

ANTIBODY; ETHYLENE GLYCOL DIMESYLATE; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERSTITIAL FLUID; LEYDIG CELL; MACROPHAGE MIGRATION INHIBITION; MALE; MESENCHYME CELL; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGONIUM; TESTIS;

ANIMALS; BODY FLUIDS; IMMUNOHISTOCHEMISTRY; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MESYLATES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TESTIS;

ANIMALIA;

EID: 0032979925     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bacher, M., Meinhardt, A., Lan, H. Y., Mu, W., Metz, C. N., Chesney, J. A., Calandra, T., Gemsa, D., Donnelly, T., Atkins, R. C. and Bucala, R. (1997). MIF expression in experimentally-induced endotoxemia. Am. J. Pathol. 150, 235-246.
2. Bernhagen, J., Calandra, T., Mitchell, R. A., Martin, S. B., Tracey, K. J., Voelter, W., Manogue, K. R., Cerami, A. and Bucala, R. (1993). MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature 365, 756-759.
3. Calandra, T., Bernhagen, J., Mitchell, R. A. and Bucala, R. (1994). The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 179, 1895-1902.
4. Calandra, T., Bernhagen, J., Metz, C. N., Spiegel, L. A., Bacher, M., Donnelly, T., Cerami, A. and Bucala, R. (1995). MIF as a glucocorticoid induced modulator of cytokine production. Nature 377, 66-71.
5. Chomczynski, P. and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
6. David, J. (1966). Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc. Nat. Acad. Sci. USA 56, 72-77.
7. Duckett, R. J., Hedger, M. P., McLachlan, R. I. and Wreford, N. G. (1997). The effects of gonadotropin-releasing hormone-immunisation and recombinant follicle-stimulating hormone on the Leydig cell and macrophage populations of the adult rat testis. J. Androl. 18, 417-423.
8. Fort, P., Piechaczyk, M., El Sabrouty, S., Dani, C., Jeanteur, C. P. and Blanchard, J. M. (1985). Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucl. Acid Res. 13, 1431-1442.
9. Gaytan, F., Bellido, C., Romero, J. L., Morales, C., Reymundo, C. and Aguilar, E. (1994) Decreased number and size and the defective function of testicular macrophages in long-term hypophysectomized rats are reversed by treatment with human gonadotrophins. J. Endocrinol. 140, 399-407.
10. Hayes, R., Chalmers, S. J., Nikolic-Paterson. D., Atkins, R. C. and Hedger, M. P. (1996). Secretion of bioactive interleukin-1 by rat testicular macrophages in vitro. J. Androl. 17, 41-49.
11. Hedger, M. P. and Eddy, E. M. (1986). Monoclonal antibodies against rat Leydig cell surface antigens. Biol. Reprod. 35, 1309-1319.
12. Hedger, M. P. and Hettiarachchi, S. (1994). Measurement of immunoglobulin G levels in adult rat testicular interstitial fluid and serum. J. Androl. 15, 583-590.
13. Hedger, M. P. (1997). Testicular leukocytes: what are they doing? Rev. Repmd. 2, 38-47.
14. + lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants. Biol. Reprod. 58, 935-942.
15. Hutson, J. C. ( 1998) Interactions between testicular macrophages and Leydig cells. J. Androl. 19, 394-398.
16. Jackson, A. E., O'Leary, P. C., Ayers, M. M., and de Kretser, D. M. (1986). The effects of ethylene dimethane sulphonate (EDS) on rat Leydig cells: Evidence to support a connective tissue origin of Leydig cells. Biol. Reprod. 35, 425-437.
17. Kerr, J. B., Mayberry, R. A. and Irby, D. C. (1984). Morphometric studies on lipid inclusions in Sertoli cells during the spermatogenic cycle in the rat. Cell Tissue Res. 236, 699-709.
18. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
19. Leeming, G., Lendon, R., McLean, J. M. and Morris, I. D. (1991). Changes in the rat lymphoid tissues after Leydig cell destruction by EDS. Exp. Pathol. 41, 115-120.
20. Meinhardt, A., Bacher, M., McFarlane, J. R., Metz, C. N., Seitz, J., Hedger, M. P., de Kretser, D. M. and Bucala, R. (1996). The macrophage migration inhibitory factor (MIF) production by Leydig cells: evidence for a role in regulation of testicular function. Endocrinology 137, 5090-5095.
21. Mitchell, R., Bacher, M., Bernhagen, J., Pushkarskava, T., Seidin, M. F. and Bucala, R. (1995). Cloning and characterization of the gene for mouse macrophage migration inhibitory factor (MIF). J. Immunol. 154, 3863-3870.
22. Morris, I. (1985). Leydig cell resistance to the cytotoxic effects of ethylene dimethanesulphonate in the adult rat testis. J. Endocrinol 105, 311-316.
23. Nathan, C. F., Remold, H. G. and David, J. R. (1973). Characterization of a lymphocyte factor which alters macrophage function. J. Exp. Med. 137, 275-288.
24. Nishihira, J., Kuriyama, T., Sakai, M., Nishi. S., Ohki, S. and Hikichi, K. (1995). The structure and physicochemical properties of rat liver macrophage migration inhibitory factor. Biochim. Biophys. Acta 1247, 159-162.
25. O'Leary, P. C., Jackson, A. E., Irby, D. C. and de Kretser, D. M. (1987). Effects of ethane dimethane sulphonate (EDS) on seminiferous tubule function in rats. Int. J. Androl. 10, 625-634.
26. Roberts, K. P. and Griswold, M. D. (1990). Ethylene dimethanesulfonate inhibits the function of Sertoli cells in culture at sublethal doses. Endocrinology 126, 1618-1622.
27. Rommerts, F. F. G., Teerds, K. J. and Hoogerbrugge, J. W. (1988). In vitro effects of ethylene-dimethane sulfonate (EDS) on Leydig cells: inhibition of steroid production and cytologic effects are dependent on species and age of rat. Mol. Cell. Endocrinol. 55, 87-94.
28. Sakai, M., Nishihira, J., Hibiya, Y., Koyama, Y. and Nishi, S. (1994). Glutathione binding rat liver 13k protein is homologous of the macrophage migration inhibitory factor. Biochem. Mol. Biol. Int. 33, 439-446.
29. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular cloning: a laboratory manual. Cold Spring Harbour Laboratory Press, New York., 2nd edition.
30. Schagger, H. and von Jagow, G. (1987). Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166, 368-379.
31. Sharpe, R. M. and Cooper, I. (1984). Intratesticular secretion of a factor(s) with major stimulatory effects on Leydig cell testosterone secretion in vitro. Mol. Cell. Endocrinol. 37, 159-168.
32. Teerds, K. J., de Rooij, D. G., Rommerts, F. F. G., van den Hurk, R. and Wensing, C. J. G. (1989). Proliferation and differentiation of possible Leydig cell precursors after destruction of the exsiting Leydig cells with ethane dimethane sulphonate: the role of LH/human chorionic gonadotrophin. J. Endocrinol. 122, 689-696.
33. Teerds, K. J., Rommerts, F. F. G. and Dorrington, J. H. (1990). Immunohistochemical detection of transforming growth factor-α in Leydig cells during the development of the rat testis. Mol. Cell. Endocrinol. 69, R1-R6.
34. Towbin, H., Staehelin, T. and Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Nat. Acad. Sci. USA. 76, 4350-4354.
35. Verhoeven, G., Cailleu, J. and Morris, I. D. (1989). Inhibitory effects of alkane sulphonates on the function of immature rat Leydig, Sertoli and peritubular cells cultured in vitro. J. Mol. Endocrinol. 2, 145-155.
36. Waeber, G., Calandra, T., Roduit, R., Haefliger, J.-A., Thompson, N., Thorens, B., Temler, E., Meinhardt, A., Bacher, M., Metz, C. N., Nicod, P. and Bucala, R. (1997). Insulin secretion regulated by the glucose-dependent production of islet β-cell MIF. Proc. Nat. Acad. Sci. USA 94, 4782-4787.
37. Wang, J., Wreford, N. G. M., Lan, H. Y. and Hedger, M. P. (1994). Leukocyte populations of the rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol. Reprod. 51, 551-561.