메뉴 건너뛰기




Volumn 38, Issue 6, 2000, Pages 747-761

Muscarinic toxins: Novel pharmacological tools for the muscarinic cholinergic system

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC RECEPTOR; RECEPTOR SUBTYPE; SNAKE VENOM; TOXIN;

EID: 0033964813     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(99)00196-8     Document Type: Review
Times cited : (53)

References (59)
  • 1
    • 0024284068 scopus 로고
    • Toxins from the venom of the green mamba Dendroaspis angusticeps that inhibit the binding of quinuclidinyl benzilate to muscarinic acetylcholine receptors
    • Adem A., Asblom A., Johansson G., Mbugua P.M., Karlsson E. Toxins from the venom of the green mamba Dendroaspis angusticeps that inhibit the binding of quinuclidinyl benzilate to muscarinic acetylcholine receptors. Biochem Biophys Acta. 968:1988;340-345.
    • (1988) Biochem Biophys Acta , vol.968 , pp. 340-345
    • Adem, A.1    Asblom, A.2    Johansson, G.3    Mbugua, P.M.4    Karlsson, E.5
  • 2
    • 0030945299 scopus 로고    scopus 로고
    • Muscarinic receptor subtype selective toxins
    • Adem A., Karlsson E. Muscarinic receptor subtype selective toxins. Life Sci. 60:1997;1069-1076.
    • (1997) Life Sci. , vol.60 , pp. 1069-1076
    • Adem, A.1    Karlsson, E.2
  • 3
    • 0023191072 scopus 로고
    • Identification of a family of muscarinic acetylcholine receptor genes
    • Bonner T., Buckley N., Young A., Brann M. Identification of a family of muscarinic acetylcholine receptor genes. Science. 237:1987;527-532.
    • (1987) Science , vol.237 , pp. 527-532
    • Bonner, T.1    Buckley, N.2    Young, A.3    Brann, M.4
  • 4
    • 0029918190 scopus 로고    scopus 로고
    • Autoradiographic evidence that 3-quinuclidinyl-4-fluorobenzilate (FQNB) displays in vivo selectivity for the m2 subtype
    • Boulay S., Sood V., Rayeq M., Cohen V., Zeeberg B., Reba R. Autoradiographic evidence that 3-quinuclidinyl-4-fluorobenzilate (FQNB) displays in vivo selectivity for the m2 subtype. Neuroimage. 3:1996;35-39.
    • (1996) Neuroimage , vol.3 , pp. 35-39
    • Boulay, S.1    Sood, V.2    Rayeq, M.3    Cohen, V.4    Zeeberg, B.5    Reba, R.6
  • 5
    • 0343516842 scopus 로고    scopus 로고
    • Use of muscarinic toxins, MTx1 and MTx3, in the study of synaptic transmission in the peripheral nervous system
    • Bradley K., Harvey A., Rowan G. Use of muscarinic toxins, MTx1 and MTx3, in the study of synaptic transmission in the peripheral nervous system. Life Sciences. 60:1997;1207.
    • (1997) Life Sciences , vol.60 , pp. 1207
    • Bradley, K.1    Harvey, A.2    Rowan, G.3
  • 6
    • 0027208248 scopus 로고
    • Muscarinic receptors. Characterization, coupling and function
    • Caulfield M. Muscarinic receptors. Characterization, coupling and function. Pharmacol Ther. 58:1993;319-379.
    • (1993) Pharmacol Ther , vol.58 , pp. 319-379
    • Caulfield, M.1
  • 7
    • 0022629602 scopus 로고
    • Muscarinic cholinergic receptor subtypes in the rat brain. I. Quantitative autoradiographic studies
    • Cortés R., Palacios J. Muscarinic cholinergic receptor subtypes in the rat brain. I. Quantitative autoradiographic studies. Brain Res. 362:1986;227-238.
    • (1986) Brain Res , vol.362 , pp. 227-238
    • Cortés, R.1    Palacios, J.2
  • 8
    • 0001536516 scopus 로고
    • The action of certain esters and ethers of choline, and their relation to muscarine
    • Dale H. The action of certain esters and ethers of choline, and their relation to muscarine. J Pharmacol Exp Ther. 6:1914;146-190.
    • (1914) J Pharmacol Exp Ther , vol.6 , pp. 146-190
    • Dale, H.1
  • 9
    • 0026050428 scopus 로고
    • Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues
    • Dörje F., Levey A., Brann M. Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Mol Pharmacol. 40:1991;459-462.
    • (1991) Mol Pharmacol , vol.40 , pp. 459-462
    • Dörje, F.1    Levey, A.2    Brann, M.3
  • 10
    • 0026082090 scopus 로고
    • Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence
    • Ducancel F., Rowan E., Cassar E., Harvey A., Ménez A., Boulain J. Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence. Toxicon. 29:1991;516-520.
    • (1991) Toxicon , vol.29 , pp. 516-520
    • Ducancel, F.1    Rowan, E.2    Cassar, E.3    Harvey, A.4    Ménez, A.5    Boulain, J.6
  • 11
    • 0027005952 scopus 로고
    • Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: Distinction of receptor subtypes in antagonist competition assays
    • Frey K., Howland M. Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: distinction of receptor subtypes in antagonist competition assays. J Pharmacol Exp Ther. 263:1992;1391-1400.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 1391-1400
    • Frey, K.1    Howland, M.2
  • 12
    • 0020421340 scopus 로고
    • Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization
    • Hammer R., Giachetti A. Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization. Life Sci. 31:1982;2991-2998.
    • (1982) Life Sci , vol.31 , pp. 2991-2998
    • Hammer, R.1    Giachetti, A.2
  • 13
    • 0018858710 scopus 로고
    • Dendrotoxin from the venom of the Green Mamba, Dendroaspis angusticeps
    • Harvey A., Karlsson E. Dendrotoxin from the venom of the Green Mamba, Dendroaspis angusticeps. Naunyn-Schmiedeberg's Arch Pharmacol. 312:1980;1-6.
    • (1980) Naunyn-Schmiedeberg's Arch Pharmacol , vol.312 , pp. 1-6
    • Harvey, A.1    Karlsson, E.2
  • 14
    • 0343516840 scopus 로고
    • Polypeptide neurotoxins from mamba venoms that facilitate transmitter release
    • Harvey A., Karlsson E. Polypeptide neurotoxins from mamba venoms that facilitate transmitter release. Trends Pharmacol Sci. 5:1984;71-72.
    • (1984) Trends Pharmacol Sci , vol.5 , pp. 71-72
    • Harvey, A.1    Karlsson, E.2
  • 17
    • 0026024378 scopus 로고
    • Muscarinic acetylcholine receptors: Structure and function
    • Hulme E., Kurtenbach E., Curtis C. Muscarinic acetylcholine receptors: structure and function. Biochem Soc Transactions. 19:1991;133-138.
    • (1991) Biochem Soc Transactions , vol.19 , pp. 133-138
    • Hulme, E.1    Kurtenbach, E.2    Curtis, C.3
  • 18
    • 0027744261 scopus 로고
    • Agonist activation of muscarinic acetylcholine receptors
    • Hulme E., Curtis C., Page K., Jones P. Agonist activation of muscarinic acetylcholine receptors. Cellular Signalling. 5:1995;687-694.
    • (1995) Cellular Signalling , vol.5 , pp. 687-694
    • Hulme, E.1    Curtis, C.2    Page, K.3    Jones, P.4
  • 19
    • 0007256297 scopus 로고
    • Mechamism of the amnestic action of scopolamine
    • Izquierdo I. Mechamism of the amnestic action of scopolamine. Trends Pharmacol Sci. 12:1989;128-129.
    • (1989) Trends Pharmacol Sci , vol.12 , pp. 128-129
    • Izquierdo, I.1
  • 21
    • 4243551726 scopus 로고
    • Two new peptides from Dendroaspis angusticeps venom: Are they muscarinic cholinergic toxins?
    • Jerusalinsky D., Cerveñansky C., De Robertis E., Dajas F. Two new peptides from Dendroaspis angusticeps venom: are they muscarinic cholinergic toxins? J Neurochem. 52:(Suppl.):1989;S92B.
    • (1989) J Neurochem , vol.52 , Issue.SUPPL.
    • Jerusalinsky, D.1    Cerveñansky, C.2    De Robertis, E.3    Dajas, F.4
  • 22
    • 0026805538 scopus 로고
    • Two polypeptides from Dendroaspis angusticeps venom selectively inhibit the binding of central muscarinic cholinergic receptor ligands
    • Jerusalinsky D., Cerveñansky C., Peña C., Raskovsky S., Dajas F. Two polypeptides from Dendroaspis angusticeps venom selectively inhibit the binding of central muscarinic cholinergic receptor ligands. Neurochem Int. 20:1992;237-246.
    • (1992) Neurochem Int , vol.20 , pp. 237-246
    • Jerusalinsky, D.1    Cerveñansky, C.2    Peña, C.3    Raskovsky, S.4    Dajas, F.5
  • 23
    • 0027337654 scopus 로고
    • A peptide muscarinic toxin from the Green Mamba venom shows agonist-like actions in an inhibitory avoidance learning task
    • Jerusalinsky D., Cerveñansky C., Walz R., Bianchin M., Izquierdo I. A peptide muscarinic toxin from the Green Mamba venom shows agonist-like actions in an inhibitory avoidance learning task. Eur J Pharmacol. 240:1993;103-105.
    • (1993) Eur J Pharmacol , vol.240 , pp. 103-105
    • Jerusalinsky, D.1    Cerveñansky, C.2    Walz, R.3    Bianchin, M.4    Izquierdo, I.5
  • 24
    • 0027973761 scopus 로고
    • Toxins from mamba venoms: Small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors
    • Jerusalinsky D., Harvey A. Toxins from mamba venoms: small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors. Trends in Phar Sci. 15:1994;424-430.
    • (1994) Trends in Phar Sci , vol.15 , pp. 424-430
    • Jerusalinsky, D.1    Harvey, A.2
  • 25
  • 26
    • 0030941163 scopus 로고    scopus 로고
    • Cholinergic neurotransmission and synaptic plasticity concerning memory processing
    • Jerusalinsky D., Kornisiuk E., Izquierdo I. Cholinergic neurotransmission and synaptic plasticity concerning memory processing. Neurochemical Res. 22:1997;507-515.
    • (1997) Neurochemical Res , vol.22 , pp. 507-515
    • Jerusalinsky, D.1    Kornisiuk, E.2    Izquierdo, I.3
  • 28
    • 0030623767 scopus 로고    scopus 로고
    • The use of muscarinic toxins in the study of muscarinic receptors
    • Jerusalinsky D., Harvey A., Karlsson E., Potter L. The use of muscarinic toxins in the study of muscarinic receptors. Life Sciences. 60:1997;1161-1162.
    • (1997) Life Sciences , vol.60 , pp. 1161-1162
    • Jerusalinsky, D.1    Harvey, A.2    Karlsson, E.3    Potter, L.4
  • 31
    • 0029048093 scopus 로고
    • A snake toxin against muscarinic acetylcholine receptors: Amino acid sequence, subtype specificity and effect on guinea-pig ileum
    • Jolkonnen M., Adem A., Hellman U., Wernstedt C., Karlsson E. A snake toxin against muscarinic acetylcholine receptors: amino acid sequence, subtype specificity and effect on guinea-pig ileum. Toxicon. 33:1995;399-410.
    • (1995) Toxicon , vol.33 , pp. 399-410
    • Jolkonnen, M.1    Adem, A.2    Hellman, U.3    Wernstedt, C.4    Karlsson, E.5
  • 32
    • 0003664123 scopus 로고    scopus 로고
    • Comprehensive summaries of Uppsala dissertations from the faculty of Science and Technology 183, Acta Universitatis Upsaliensis, Uppsala, Sweden
    • Jolkonnen, M., 1996. Muscarinic toxin from Dendroaspis (mamba) venom. Comprehensive summaries of Uppsala dissertations from the faculty of Science and Technology 183, Acta Universitatis Upsaliensis, Uppsala, Sweden.
    • (1996) Muscarinic Toxin from Dendroaspis (Mamba) Venom
    • Jolkonnen, M.1
  • 34
    • 0026021093 scopus 로고
    • Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor
    • Karlsson E., Risinger C., Jolkkonen M., Wernstedt C., Adem A. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon. 29:1991;521-526.
    • (1991) Toxicon , vol.29 , pp. 521-526
    • Karlsson, E.1    Risinger, C.2    Jolkkonen, M.3    Wernstedt, C.4    Adem, A.5
  • 36
    • 0028903441 scopus 로고
    • Binding of muscarinic toxins MTx1 and MTx2 from the venom of the green mamba Dendroaspis angusticeps to cloned human muscarinic cholinoceptors
    • Kornisiuk E., Jerusalinsky D., Cerveñansky C., Harvey A. Binding of muscarinic toxins MTx1 and MTx2 from the venom of the green mamba Dendroaspis angusticeps to cloned human muscarinic cholinoceptors. Toxicon. 33:1995;11-18.
    • (1995) Toxicon , vol.33 , pp. 11-18
    • Kornisiuk, E.1    Jerusalinsky, D.2    Cerveñansky, C.3    Harvey, A.4
  • 40
    • 0025572697 scopus 로고
    • Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart and NG 108-15 cells
    • Lazareno S., Buckley N., Roberts F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart and NG 108-15 cells. Molec Pharmacol. 38:1990;805-815.
    • (1990) Molec Pharmacol , vol.38 , pp. 805-815
    • Lazareno, S.1    Buckley, N.2    Roberts, F.3
  • 41
    • 0027465882 scopus 로고
    • Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain
    • Levey A. Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci. 52:1993;441-443.
    • (1993) Life Sci , vol.52 , pp. 441-443
    • Levey, A.1
  • 43
    • 0027485462 scopus 로고
    • Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors
    • Max S., Liang J.S., Potter L.T. Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors. J Neurosci. 13:1993;4293-4300.
    • (1993) J Neurosci , vol.13 , pp. 4293-4300
    • Max, S.1    Liang, J.S.2    Potter, L.T.3
  • 44
    • 0027358761 scopus 로고
    • Use of m1-toxin as a selective antagonist of m1 muscarinic receptors
    • Max S., Liang J.S., Valentine H., Potter L. Use of m1-toxin as a selective antagonist of m1 muscarinic receptors. J Pharmacol Exp Ther. 267:1993;480-485.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 480-485
    • Max, S.1    Liang, J.S.2    Valentine, H.3    Potter, L.4
  • 45
    • 0023161083 scopus 로고
    • Molecular properties of the muscarinic acetylcholine receptor
    • Nathanson N. Molecular properties of the muscarinic acetylcholine receptor. Ann Rev Neurosci. 10:1987;195-236.
    • (1987) Ann Rev Neurosci , vol.10 , pp. 195-236
    • Nathanson, N.1
  • 46
    • 0029922183 scopus 로고    scopus 로고
    • Rat striatal muscarinic receptors coupled to the inhibition of adenylyl cyclase activity: Potent block by the selective m4 ligand muscarinic toxin 3 (MT3)
    • Olianas M., Adem A., Karlsson E., Onali P. Rat striatal muscarinic receptors coupled to the inhibition of adenylyl cyclase activity: potent block by the selective m4 ligand muscarinic toxin 3 (MT3). Brit J Pharmacol. 118:1996;283-288.
    • (1996) Brit J Pharmacol , vol.118 , pp. 283-288
    • Olianas, M.1    Adem, A.2    Karlsson, E.3    Onali, P.4
  • 47
    • 0343952742 scopus 로고    scopus 로고
    • Differential effect of muscarinic toxin (MT3) on brain muscarinic receptors coupled to adenylyl cyclase
    • Olianas M., Adem A., Karlsson E., Onali P. Differential effect of muscarinic toxin (MT3) on brain muscarinic receptors coupled to adenylyl cyclase. Life Sci. 60:1997;1206.
    • (1997) Life Sci , vol.60 , pp. 1206
    • Olianas, M.1    Adem, A.2    Karlsson, E.3    Onali, P.4
  • 48
    • 0032544791 scopus 로고    scopus 로고
    • Identification of rat brain muscarinic m4 receptor coupled to cyclic AMP using the selective muscarinic toxin 3
    • Olianas M., Adem A., Karlsson E., Onali P. Identification of rat brain muscarinic m4 receptor coupled to cyclic AMP using the selective muscarinic toxin 3. Eur. J. Pharmacol. 357:1998;235-242.
    • (1998) Eur. J. Pharmacol. , vol.357 , pp. 235-242
    • Olianas, M.1    Adem, A.2    Karlsson, E.3    Onali, P.4
  • 50
    • 0001315774 scopus 로고    scopus 로고
    • Cloning and expression of the cDNA for an m1-toxin
    • Potter L., Krajewski J., Dickerson I. Cloning and expression of the cDNA for an m1-toxin. Life Sciences. 60:1996;1205.
    • (1996) Life Sciences , vol.60 , pp. 1205
    • Potter, L.1    Krajewski, J.2    Dickerson, I.3
  • 51
    • 0020956527 scopus 로고
    • Fasciculin, a powerful anticholinesterase polypeptide from Dendroaspis angusticeps venom
    • Rodríguez-Ithurralde D., Silveira R., Barbeito L., Dajas F. Fasciculin, a powerful anticholinesterase polypeptide from Dendroaspis angusticeps venom. Neurochem Int. 5:1983;267-274.
    • (1983) Neurochem Int , vol.5 , pp. 267-274
    • Rodríguez-Ithurralde, D.1    Silveira, R.2    Barbeito, L.3    Dajas, F.4
  • 52
    • 0031841088 scopus 로고    scopus 로고
    • Differential presynaptic and postsynaptic expression of m1-m4 muscarinic acetylcholine receptors at the perforant pathway/granule cell synapse
    • Rouse S.T., Gilmor M., Levey A. Differential presynaptic and postsynaptic expression of m1-m4 muscarinic acetylcholine receptors at the perforant pathway/granule cell synapse. Neuroscience. 86:1998;221-232.
    • (1998) Neuroscience , vol.86 , pp. 221-232
    • Rouse, S.T.1    Gilmor, M.2    Levey, A.3
  • 53
    • 0029096073 scopus 로고
    • A particularly labile Asp-Pro bond in the green mamba muscarinic toxin MTX2. Effect of protein conformation on the rate of cleavage
    • Ségalas I., Thai R., Ménez R., Vita C. A particularly labile Asp-Pro bond in the green mamba muscarinic toxin MTX2. Effect of protein conformation on the rate of cleavage. FEBS Lett. 371:1995;171-175.
    • (1995) FEBS Lett , vol.371 , pp. 171-175
    • Ségalas, I.1    Thai, R.2    Ménez, R.3    Vita, C.4
  • 54
    • 0029077225 scopus 로고
    • Purification and sequence determination of a new muscarinic toxin (MT4) from the venom of the green mamba (Dendroaspis angusticeps)
    • Vandermeers A., Vandermeers-Piret M., Rathe J., Waelbröeck M., Oras A., Karlsson E. Purification and sequence determination of a new muscarinic toxin (MT4) from the venom of the green mamba (Dendroaspis angusticeps). Toxicon. 33:1995;1171-1179.
    • (1995) Toxicon , vol.33 , pp. 1171-1179
    • Vandermeers, A.1    Vandermeers-Piret, M.2    Rathe, J.3    Waelbröeck, M.4    Oras, A.5    Karlsson, E.6
  • 55
    • 0033030642 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: A review of immunocytochemical localisation in relation to learning and memory
    • Van Der Zee E., Luiten P.G. Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localisation in relation to learning and memory. Progress in Neurobiology. 58:1999;409-471.
    • (1999) Progress in Neurobiology , vol.58 , pp. 409-471
    • Van Der Zee, E.1    Luiten, P.G.2
  • 56
    • 0025793911 scopus 로고
    • Production of antisera selective for m1 muscarinic receptors using fusion proteins: Distribution of m1 receptors in rat brain
    • Wall S., Yasuda R., Hory F., Flagg S., Martin B., Ginns E., Wolfe B. Production of antisera selective for m1 muscarinic receptors using fusion proteins: distribution of m1 receptors in rat brain. Mol Pharmacol. 39:1991;643-649.
    • (1991) Mol Pharmacol , vol.39 , pp. 643-649
    • Wall, S.1    Yasuda, R.2    Hory, F.3    Flagg, S.4    Martin, B.5    Ginns, E.6    Wolfe, B.7
  • 57
    • 0002683898 scopus 로고
    • Drugs acting at sinaptic and neuroeffector junctional sites
    • A. Gilman, L. Goodman, T. Rall, & F. Murad. New York: MacMillan Ltd
    • Weiner N., Taylor P. Drugs acting at sinaptic and neuroeffector junctional sites. Gilman A., Goodman L., Rall T., Murad F. Goodman & Gilman's Pharmacological Basis of Therapeutics. 1985;66-235 MacMillan Ltd, New York.
    • (1985) Goodman & Gilman's Pharmacological Basis of Therapeutics , pp. 66-235
    • Weiner, N.1    Taylor, P.2
  • 58
    • 0025911432 scopus 로고
    • Habituation and inhibitory avoidance training alter brain regional levels of benzodiazepine-like molecules and are affected by intracerebral flumazenil microinjection
    • Wolfman C., Da Cunha C., Jerusalinsky D., Levi de Stein M., Viola H., Izquierdo I., Medina J. Habituation and inhibitory avoidance training alter brain regional levels of benzodiazepine-like molecules and are affected by intracerebral flumazenil microinjection. Brain Res. 548:1991;74-80.
    • (1991) Brain Res , vol.548 , pp. 74-80
    • Wolfman, C.1    Da Cunha, C.2    Jerusalinsky, D.3    Levi De Stein, M.4    Viola, H.5    Izquierdo, I.6    Medina, J.7
  • 59
    • 0027497533 scopus 로고
    • Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: Distribution of m4 and m5 receptors in rat brain
    • Yasuda R., Ciesla W., Flores L., Wall S., Li M., Satkus S., Weisstein J., Spagnola B., Wolfe B. Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain. Mol Pharmacol. 43:1993;149-157.
    • (1993) Mol Pharmacol , vol.43 , pp. 149-157
    • Yasuda, R.1    Ciesla, W.2    Flores, L.3    Wall, S.4    Li, M.5    Satkus, S.6    Weisstein, J.7    Spagnola, B.8    Wolfe, B.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.