Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino) 1-(3-pyridyl)-1-butanone in smokers

Cancer Epidemiology Biomarkers and Prevention

Volumn 6, Issue 7, 1997, Pages 517-522

  Taioli, Emanuela ^a,b,d   Garbers, Samantha ^a   Bradlow, H Leon ^c   Carmella, Steven G ^d   Akerkar, Shobha ^e   Hecht, Stephen S ^d  

^a NEW YORK UNIVERSITY   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c STRANG CANCER PREVENTION CENTER   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CARCINOGEN;

ADULT; ARTICLE; CHEMICAL ANALYSIS; CIGARETTE SMOKING; CLINICAL ARTICLE; DIET; FEMALE; HUMAN; METABOLITE; PRIORITY JOURNAL; URINALYSIS; VEGETABLE;

ADULT; ANTICARCINOGENIC AGENTS; BIOTRANSFORMATION; CARCINOGENS; FEMALE; HUMANS; INDOLES; METABOLIC CLEARANCE RATE; NITROSAMINES; SMOKING;

EID: 0030812399     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Sones, K., Heaney, R. K., and Fenwick, O. R. An estimate of the mean daily intake of glucosinolates from cruciferous vegetables in the U. K. J. Sci. Food Agric., 35: 712-720, 1984.
2. Wattenberg, L. W., and Loub, W. D. Inhibition of polycyclic aromatic hydrocarbon induced neoplasia by naturally occurring indoles. Cancer Res., 38: 1410-1413, 1978.
3. Grubbs, C. J., Steele, V. E., Casebolt, T., Juliana, M. M., Eto, J., Whitaker, L. M., Dragner, K. H., Kelloff, G. J., and Lubet, R. L. Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res., 15: 709-716, 1995.
4. Tanaka, T., Mori, Y., Morishita, Y., Hara, A., Ohno, T., Kojima, T., and Mori, H. Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats. Carcinogenesis (Lond.), 18: 1403-1406, 1990.
5. Morse, M. A., LeGreca, S. D., Amin, S., and Chung, F-L. Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and on the metabolism and disposition of NNK in A/J mice. Cancer Res., 50: 2613-2617, 1990.
6. Tanaka, T., Toshihiro, K., Morishita, Y., and Mon, H. Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tonsue carcinosenesis. Cancer Res., 83: 835-842, 1992.
7. Bailey, G. S., Hendricks, J. D., Shelton, D. W., Nixon, J. E., and Pawlowski, N. E. Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol. J. Natl. Cancer Inst., 78: 931-934, 1987.
8. 1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer Res., 51: 2362-2365, 1991.
9. Pence, B. C., Buddingh, F., and Yang, S. P. Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. J. Natl. Cancer Inst., 77: 269-276, 1986.
10. Bradlow, H. L., Hershcopf, R. J., Martucci, C. P., and Fishman, J. Estradiol 16α-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans. Proc. Natl. Acad. Sci. USA, 82: 6295-6299, 1985.
11. Bradlow, H. L., Michnovicz, J. J., Telang, N. T., and Osborne, M. P. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis (Lond.), 12: 1571-1574, 1991.
12. Kojima, T., Tanaka, T., and Mori, H. Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol. Cancer Res., 54: 1446-1449, 1994.
13. Bradlow, H. L., Michnovicz, J. J., Halper, M., Miller, D. G., Wong, G. Y. C., and Osborne, M. P. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol., Biomarkers & Prev., 3: 591-595, 1994.
14. Minchovicz, J. J., and Bradlow, H. L. Induction of estradiol metabolism by dietary indole-3-carbinol in humans. J. Natl Cancer Inst., 82: 947-950, 1990.
15. Kohlmeyer K., and Dortchy R. The effect of cruciferous vegetable consumption on breast cancer incidence. Int. J. Epidemiol., in press, 1997.
16. Schertzer, H. G., and Sainsbury, M. Chemoprotective and hepatic enzyme induction properties of indole and indenoindole antioxidants in rats. Food Chem. Toxicol., 29: 391-400, 1991.
17. Wortelboer, H. M., van der Linden, E. C. M., deKruif, C. A., Noordhoek, J., Blaauboer, B. J., van Bladeren, P. J., and Falke, H. E. Effects of indole-3-carbinol on biotransformation enzymes in the rat: in riro changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures. Food Chem. Toxicol., 30: 589-599, 1992.
18. 1 in the rat. Drug Metab. Disp., 22: 383-391, 1994.
19. Schertzer, H. G., and Sainsbury, M. Intrinsic acute toxicity and hepatic enzyme inducing properties of the chemoprotectants indole-3-carbinol and 5,10-dehydroindeno [1,2-b] indole in mice. Food Chem. Toxicol., 29: 237-242, 1991.