Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species

Synapse

Volumn 35, Issue 3, 2000, Pages 228-233

  Cadet, Jean Lud ^a   Harrington, Beverly ^a   Ordonez, Sonia ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Apoptosis; Catecholamines; Dopamine; Free radical production; Neurodegenerative disease; Parkinson's disease

Indexed keywords

DOPAMINE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; NERVE CELL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033955583     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2396(20000301)35:3<228::aid-syn8>3.0.co;2-%23     Document Type: Article

References (16)

1. Akao Y, Otsuki Y, Kataoka S, Ito Y, Tsujimoto Y. 1994. Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes. Cancer Res 54:2468-2471.
2. Cadet JL, Brannock C. 1998. Free radicals and the pathobiology of brain dopamine systems. Neurochem Int 32:117-131.
3. Cadet JL, Ordonez SV, Ordonez JV. 1997. Methamphetamine induces apoptosis in immortalized neural cells: protection by the proto-oncogene, bcl-2. Synapse 25:176-184.
4. Cheng N-m, Maeda T, Kume T, Kaneko S, Kochiyama H, Alaike A, Goshima Y, Misu Y. 1996. Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons. Brain Res 743:278-283.
5. Hastings TG, Zigmond MJ. 1997. Loss of dopaminergic neurons on parkinsonism: possible role of reactive dopamine metabolites. J Neural Transm (Suppl.) 49:103-110.
6. Hochman A, Sternin H, Gorodin S, Korsmeyer S, Ziv I, Melamed E, Offen D. 1998. Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J Neurochem 71:741-748.
7. Hockenbery DM, Oltavi ZM, Yin X-M, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 functions in an antioxidant pathways to prevent apoptosis. Cell 75:241-251.
8. Itzhak Y, Martin JL, Blak MD, Ali SF. 1998. Effect of melatonin on methamphetamine- and 1-methy-4-pheyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity and methamphetamine-induced behavioral sensitization. Neuropharmacology 37:781-791.
9. Kane DJ, Sarafian TA, Anton R, Gralla EB, Valetine JS, Ord T, Bredesen DE. 1993. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262:1274-1277.
10. Li X, Darzynkiewicz Z. 1995. Labeling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation. Cell Prolif 28:572-579.
11. Masserano JM, Gong L, Kulaga H, Baker I, Wyatt RJ. 1996. Dopamine induces apoptotic cell death of a catecholaminergic cell line derived from the central nervous system. Mol Pharmacol 50:1309-1315.
12. Michel PP, Hefti F. 1990. Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture. J Neurosci Res 26:428-435.
13. Offen D, Ziv I, Barzilai A, Gorodin S, Glater E, Hochman A, Melamed E. 1997. Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease. Neurochem Int 31:207-216.
14. Tsujimoto Y, Finger LR, Ynis J, Nowell PC, Croce CM. 1984. Cloning of the chromosome breakpoint of neoplastic B cells with the t (14; 18) chromosome translocation. Science 226:1097-1099.
15. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE. 1993. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 90:4533-4537.
16. Ziv I, Barzilai A, Offen D, Nardi N, Melamed E. 1997. Nigrostriatal neuronal death in Parkinson's disease - a passive or an active genetically-controlled process? J Neural Transm (Suppl.) 49:69-76.