-
1
-
-
0030605509
-
The biochemistry of transcription in eukaryotes: A paradigm for multisubunit regulatory complexes
-
Tjian R. The biochemistry of transcription in eukaryotes: a paradigm for multisubunit regulatory complexes. Philos Trans R Soc Lond B Biol Sci. 351:1996;491-499.
-
(1996)
Philos Trans R Soc Lond B Biol Sci
, vol.351
, pp. 491-499
-
-
Tjian, R.1
-
2
-
-
0029866234
-
Sequences homologous to yeast mitochondrial and bacteriophage T7 RNA polymerase are widespread throughout the eukaryotic lineage
-
Cermakian N., Ikeda T.M., Cedergren R., Gray M.W. Sequences homologous to yeast mitochondrial and bacteriophage T7 RNA polymerase are widespread throughout the eukaryotic lineage. Nucleic Acids Res. 24:1996;648-654.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 648-654
-
-
Cermakian, N.1
Ikeda, T.M.2
Cedergren, R.3
Gray, M.W.4
-
4
-
-
0021984004
-
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
-
Ollis D.L., Brick P., Hamlin R., Xuaong N.G., Steitz T.A. Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature. 313:1985;762-766.
-
(1985)
Nature
, vol.313
, pp. 762-766
-
-
Ollis, D.L.1
Brick, P.2
Hamlin, R.3
Xuaong, N.G.4
Steitz, T.A.5
-
5
-
-
0032005866
-
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes
-
Brautigam C.A., Steitz T.A. Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr Opin Struct Biol. 8:1998;54-63.
-
(1998)
Curr Opin Struct Biol
, vol.8
, pp. 54-63
-
-
Brautigam, C.A.1
Steitz, T.A.2
-
6
-
-
0021154435
-
Protein-nucleic acid interactions in transcription: A molecular analysis
-
Von-Hippel P.H., Bear D.G., Morgan W., McSwiggen J. Protein-nucleic acid interactions in transcription: a molecular analysis. Annu Rev Biochem. 53:1984;389-446.
-
(1984)
Annu Rev Biochem
, vol.53
, pp. 389-446
-
-
Von-Hippel, P.H.1
Bear, D.G.2
Morgan, W.3
McSwiggen, J.4
-
7
-
-
0019319452
-
Cycling of ribonucleic acid polymerase to produce oligonucleotides during initiation in vitro at the lac UV5 promoter
-
Carpousis A.J., Gralla J.D. Cycling of ribonucleic acid polymerase to produce oligonucleotides during initiation in vitro at the lac UV5 promoter. Biochemistry. 19:1980;3245-3253.
-
(1980)
Biochemistry
, vol.19
, pp. 3245-3253
-
-
Carpousis, A.J.1
Gralla, J.D.2
-
8
-
-
0026019625
-
Structural basis for the 3′-5′ exonuclease activity of E. coli DNA polymerase I: A two metal ion mechanism
-
Beese L.S., Steitz T.A. Structural basis for the 3′-5′ exonuclease activity of E. coli DNA polymerase I: a two metal ion mechanism. EMBO J. 10:1991;25-33.
-
(1991)
EMBO J
, vol.10
, pp. 25-33
-
-
Beese, L.S.1
Steitz, T.A.2
-
9
-
-
0032527832
-
Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme
-
The authors present the first crystal structure of a T7 RNA polymerase complex, determined at 2.8 Å resolution. Many corrections to the previously determined T7 RNA polymerase structure [12] were necessary. This structure demonstrated that T7 lysozyme binds in a position remote from the active site, at the junction of the fingers, palm and N-terminal domains, suggesting that T7 lysozyme is an allosteric inhibitor
-
Jeruzalmi D., Steitz T.A. Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme. EMBO J. 17:1998;4101-4113. The authors present the first crystal structure of a T7 RNA polymerase complex, determined at 2.8 Å resolution. Many corrections to the previously determined T7 RNA polymerase structure [12] were necessary. This structure demonstrated that T7 lysozyme binds in a position remote from the active site, at the junction of the fingers, palm and N-terminal domains, suggesting that T7 lysozyme is an allosteric inhibitor.
-
(1998)
EMBO J
, vol.17
, pp. 4101-4113
-
-
Jeruzalmi, D.1
Steitz, T.A.2
-
11
-
-
0033579380
-
Structure of a transcribing T7 RNA polymerase initiation complex
-
The structure of T7 RNA polymerase complexed to a promoter, an incoming NTP and a 3-mer RNA transcript is described. The complex was prepared by an in vitro transcription reaction, using a promoter template strand with a 5′ end five base overhang (sequence CCCTC, positions +1 through +5) and a modified ATP analog to halt transcription at position +4, prior to crystallization. Evidence for why T7 RNA polymerase incorporates ribonucleotides, rather than deoxyribonucleotides, and for 'DNA scrunching' of the template strand during transcription initiation is presented
-
Cheetham G.M.T., Steitz T.A. Structure of a transcribing T7 RNA polymerase initiation complex. Science. 286:1999;2305-2309. The structure of T7 RNA polymerase complexed to a promoter, an incoming NTP and a 3-mer RNA transcript is described. The complex was prepared by an in vitro transcription reaction, using a promoter template strand with a 5′ end five base overhang (sequence CCCTC, positions +1 through +5) and a modified ATP analog to halt transcription at position +4, prior to crystallization. Evidence for why T7 RNA polymerase incorporates ribonucleotides, rather than deoxyribonucleotides, and for 'DNA scrunching' of the template strand during transcription initiation is presented.
-
(1999)
Science
, vol.286
, pp. 2305-2309
-
-
Cheetham, G.M.T.1
Steitz, T.A.2
-
12
-
-
0027163526
-
Crystal structure of T7 RNA polymerase at 3.3Å resolution
-
Sousa R., Chung Y.T., Rose J.P., Wang B.C. Crystal structure of T7 RNA polymerase at 3.3Å resolution. Nature. 364:1993;593-599.
-
(1993)
Nature
, vol.364
, pp. 593-599
-
-
Sousa, R.1
Chung, Y.T.2
Rose, J.P.3
Wang, B.C.4
-
14
-
-
0032518524
-
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
-
The authors were able to crystallize a polymerase complex with the primer-template bound at the catalytic active site. They were subsequently able to make the polymerase 'turn over' and extend the primer strand by the incorporation of further NTPs within the same crystal
-
Kiefer J.R., Mao C., Braman J.C., Beese L.S. Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature. 391:1998;304-307. The authors were able to crystallize a polymerase complex with the primer-template bound at the catalytic active site. They were subsequently able to make the polymerase 'turn over' and extend the primer strand by the incorporation of further NTPs within the same crystal.
-
(1998)
Nature
, vol.391
, pp. 304-307
-
-
Kiefer, J.R.1
Mao, C.2
Braman, J.C.3
Beese, L.S.4
-
15
-
-
0032535528
-
Crystal structure of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: Structural basis for nucleotide incorporation
-
Li U., Korolov S., Waksman G. Crystal structure of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. EMBO J. 17:1998;7514-7525.
-
(1998)
EMBO J
, vol.17
, pp. 7514-7525
-
-
Li, U.1
Korolov, S.2
Waksman, G.3
-
16
-
-
0023749703
-
Processivity of proteolytically modified forms of T7 RNA polymerase
-
Muller D.K., Martin C.T., Coleman J.E. Processivity of proteolytically modified forms of T7 RNA polymerase. Biochemistry. 27:1988;5763-5771.
-
(1988)
Biochemistry
, vol.27
, pp. 5763-5771
-
-
Muller, D.K.1
Martin, C.T.2
Coleman, J.E.3
-
17
-
-
0031046587
-
A mutant T7 RNA polymerase that is defective in RNA binding and blocked in the early stages of transcription
-
He B., Rong M., Durbin R.K., McAllister W.T. A mutant T7 RNA polymerase that is defective in RNA binding and blocked in the early stages of transcription. J Mol Biol. 265:1997;275-288.
-
(1997)
J Mol Biol
, vol.265
, pp. 275-288
-
-
He, B.1
Rong, M.2
Durbin, R.K.3
McAllister, W.T.4
-
18
-
-
0026619462
-
Substitution of a single bacteriophage T7 RNA polymerase at position 748 results in a switch in promoter specificity
-
Raskin C.A., Diaz G., Joho K., McAllister W.T. Substitution of a single bacteriophage T7 RNA polymerase at position 748 results in a switch in promoter specificity. J Mol Biol. 228:1992;506-515.
-
(1992)
J Mol Biol
, vol.228
, pp. 506-515
-
-
Raskin, C.A.1
Diaz, G.2
Joho, K.3
McAllister, W.T.4
-
21
-
-
0026763294
-
Asp537, Asp812 are essential and Lys631, His811 are catalytically significant in bacteriophage T7 RNA polymerase activity
-
Osumi-Davis P.A., de Aguilera M.C., Woody R.W., Woody A.Y. Asp537, Asp812 are essential and Lys631, His811 are catalytically significant in bacteriophage T7 RNA polymerase activity. J Mol Biol. 226:1992;37-45.
-
(1992)
J Mol Biol
, vol.226
, pp. 37-45
-
-
Osumi-Davis, P.A.1
De Aguilera, M.C.2
Woody, R.W.3
Woody, A.Y.4
-
22
-
-
0026733634
-
Mutations in T7 RNA polymerase that support a proposal for a common polymerase active site structure
-
Bonner G., Patra D., Lafer E., Sousa R. Mutations in T7 RNA polymerase that support a proposal for a common polymerase active site structure. EMBO J. 11:1992;3767-3775.
-
(1992)
EMBO J
, vol.11
, pp. 3767-3775
-
-
Bonner, G.1
Patra, D.2
Lafer, E.3
Sousa, R.4
-
23
-
-
0023663369
-
T7 lysozyme inhibits transcription by T7 RNA polymerase
-
Moffatt B.A., Studier F.W. T7 lysozyme inhibits transcription by T7 RNA polymerase. Cell. 49:1987;221-227.
-
(1987)
Cell
, vol.49
, pp. 221-227
-
-
Moffatt, B.A.1
Studier, F.W.2
-
24
-
-
0031591384
-
Mechanism of inhibition of bacteriophage T7 RNA polymerase by T7 lysozyme
-
Zhang X., Studier F.W. Mechanism of inhibition of bacteriophage T7 RNA polymerase by T7 lysozyme. J Mol Biol. 269:1997;10-27.
-
(1997)
J Mol Biol
, vol.269
, pp. 10-27
-
-
Zhang, X.1
Studier, F.W.2
-
25
-
-
0033151810
-
Low-salt crystallization of T7 RNA polymerase: A first step towards the transcription bubble complex
-
Chen C.J., Liu Z.J., Rose J.P., Wang B.C. Low-salt crystallization of T7 RNA polymerase: a first step towards the transcription bubble complex. Acta Crystallogr. D55:1999;1188-1192.
-
(1999)
Acta Crystallogr
, vol.55
, pp. 1188-1192
-
-
Chen, C.J.1
Liu, Z.J.2
Rose, J.P.3
Wang, B.C.4
-
26
-
-
0027959469
-
The thumb subdomain of T7 RNA polymerase functions to stabilize the ternary complex during processive transcription
-
Bonner G., Lafer E., Sousa R. The thumb subdomain of T7 RNA polymerase functions to stabilize the ternary complex during processive transcription. J Biol Chem. 269:1994;25129-25136.
-
(1994)
J Biol Chem
, vol.269
, pp. 25129-25136
-
-
Bonner, G.1
Lafer, E.2
Sousa, R.3
-
27
-
-
0032483398
-
Specificity in transcription regulation in the absence of specific DNA binding sites: The case of T7 lysozyme
-
Villemain J., Sousa R. Specificity in transcription regulation in the absence of specific DNA binding sites: the case of T7 lysozyme. J Mol Biol. 281:1998;793-801.
-
(1998)
J Mol Biol
, vol.281
, pp. 793-801
-
-
Villemain, J.1
Sousa, R.2
-
28
-
-
0030995087
-
Initiation, elongation and processivity of carboxyl-terminal mutants of T7 RNA polymerase
-
Gardner L.P., Mookhtiar K.A., Coleman J.E. Initiation, elongation and processivity of carboxyl-terminal mutants of T7 RNA polymerase. Biochemistry. 36:1997;2908-2918.
-
(1997)
Biochemistry
, vol.36
, pp. 2908-2918
-
-
Gardner, L.P.1
Mookhtiar, K.A.2
Coleman, J.E.3
-
29
-
-
0025883715
-
Spontaneous cleavage of RNA in ternary complexes of Escherichia coli RNA polymerase and its significance for the mechanism of transcription
-
Surratt C.K., Milan S.C., Chamberlain M.J. Spontaneous cleavage of RNA in ternary complexes of Escherichia coli RNA polymerase and its significance for the mechanism of transcription. Proc Natl Acad Sci USA. 88:1991;7983-7987.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 7983-7987
-
-
Surratt, C.K.1
Milan, S.C.2
Chamberlain, M.J.3
-
30
-
-
0028066790
-
Discontinuous mechanism of transcription elongation
-
Nudler E., Goldfarb A., Kashlev M. Discontinuous mechanism of transcription elongation. Science. 265:1994;793-796.
-
(1994)
Science
, vol.265
, pp. 793-796
-
-
Nudler, E.1
Goldfarb, A.2
Kashlev, M.3
-
31
-
-
0031028380
-
Conferring RNA polymerase activity to a DNA polymerase: A single residue in reverse transcriptase controls substrate selection
-
Gao G., Orlova M., Georgiadis M.M., Hendrickson W.A., Goff S.P. Conferring RNA polymerase activity to a DNA polymerase: a single residue in reverse transcriptase controls substrate selection. Proc Natl Acad Sci USA. 94:1997;407-411.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 407-411
-
-
Gao, G.1
Orlova, M.2
Georgiadis, M.M.3
Hendrickson, W.A.4
Goff, S.P.5
-
32
-
-
0001210090
-
Interactions of the RNA polymerase of bacteriophage T7 with its promoter during binding and initiation of transcription
-
Ikeda R.A., Richardson C.C. Interactions of the RNA polymerase of bacteriophage T7 with its promoter during binding and initiation of transcription. Proc Natl Acad Sci USA. 83:1986;3614-3818.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 3614-3818
-
-
Ikeda, R.A.1
Richardson, C.C.2
-
33
-
-
0032482990
-
RNA-binding site in T7 RNA polymerase
-
Sastry S., Ross B.M. RNA-binding site in T7 RNA polymerase. Proc Natl Acad Sci USA. 95:1998;9111-9116.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9111-9116
-
-
Sastry, S.1
Ross, B.M.2
-
34
-
-
0033538419
-
Characterization of structural features important for T7 RNAP elongation complex stability reveals competing complex conformations and a role for the non-template strand in RNA displacement
-
Gopal V., Brieba L.G., Guajardo R., McAllister W.T., Sousa R. Characterization of structural features important for T7 RNAP elongation complex stability reveals competing complex conformations and a role for the non-template strand in RNA displacement. J Mol Biol. 290:1999;411-431.
-
(1999)
J Mol Biol
, vol.290
, pp. 411-431
-
-
Gopal, V.1
Brieba, L.G.2
Guajardo, R.3
McAllister, W.T.4
Sousa, R.5
-
35
-
-
0033578701
-
Crystal structure of the Thermus aquaticus core RNA polymerase at 3.3Å resolution
-
2ββ′ core structure reveals a molecule that is shaped like a 'crab's claw' surrounding a wide internal channel through which the promoter DNA and/or RNA substrates are thought to pass
-
2ββ′ core structure reveals a molecule that is shaped like a 'crab's claw' surrounding a wide internal channel through which the promoter DNA and/or RNA substrates are thought to pass.
-
(1999)
Cell
, vol.98
, pp. 811-824
-
-
Zhang, G.1
Campbell, E.A.2
Minakhin, L.3
Richter, C.4
Severinov, K.5
Darst, S.A.6
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