Dimeric malarial drugs for enhanced activity

Drug Discovery Today

Volumn 5, Issue 2, 2000, Pages 44-45

  Bradley, David ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ALKALOID; ARTEMISININ; BENZODIAZEPINE DERIVATIVE; CHLOROQUINE; DIMER; HEMOGLOBIN; HERBACEOUS AGENT; LEXITROPSIN; OXYGEN;

DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; MALARIA; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PLASMODIUM FALCIPARUM; SHORT SURVEY;

EID: 0033950843     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(99)01453-1     Document Type: Short Survey

References (3)

1. Posner G.H.et al. Evidence for the importance of high-valent Fe=O and of a diketone in the molecular mechanism of action of antimalarial trioxane analogs of artemisinin. J. Am. Chem. Soc. 118:1996;3537.
2. Posner G.H.et al. Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides. Tetrahedron Lett. 37:1996;815.
3. Posner G.H.et al. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, troxane dimers. J. Med. Chem. 42:1999;4275-4280.