The organization of adherens junctions in mouse osteoblast-like cells (MC3T3-E1) and their modulation by triiodothyronine and 1,25-dihydroxyvitamin D3

Histochemistry and Cell Biology

Volumn 113, Issue 6, 2000, Pages 467-478

  Luegmayr, Eva ^a   Glantschnig, Helmut ^a   Varga, Franz ^a   Klaushofer, Klaus ^a  

^a HANUSCH HOSPITAL   (Austria)

Author keywords

Actin; Cadherins; Catenins; Cell confluency; Vinculin

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CADHERIN; CALCITRIOL; LIOTHYRONINE; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; PROTEIN P120; VINCULIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CONTACT; CELL DIFFERENTIATION; CELL INTERACTION; CELL JUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA;

EID: 0033945843     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180000152     Document Type: Article

References (41)

1. Babich M, Fote RP (1994) E-cadherins identified in osteoblastic cells: effects of parathyroid hormone and extracellular calcium on localization. Life Sci 54:201-208
2. Belkin AM, Koteliansky VE (1987) Interaction of iodinated vinculin, metavinculin and α-actinin with cytoskeletal proteins. FEBS Lett 220:291-294
3. Cheng S, Lecanda F, Davidson MK, Warlow PM, Zhang S, Zhang L, Suzuki S, St. John T, Civitelli R (1998) Human osteoblasts express a repertoire of cadherins, which are critical for BMP-2-induced osteogenic differentiation. J Bone Miner Res 13: 633-643
4. Doty SB (1981) Morphological evidence of gap junctions between bone cells. Calcif Tissue Int 33:509-511
5. Fratzl-Zelman N, Hörandner H, Luegmayr E, Varga F, Ellinger A, Erlee MPM, Klaushofer K (1997) Effects of triiodothyronine on the morphology of cells and matrix, the localization of alkaline phosphatase, and the frequency of apoptosis in long-term cultures of MC3T3-E1 cells. Bone 20:225-236
6. Geiger B, Ginsberg P (1991) The cytoplasmic domain of adherens-type junctions. Cell Motil Cytoskeleton 20:1-6
7. 3) and retinoic acid induce the synthesis of insulin-like growth factor binding protein 4 in mouse osteoblastic cells. Endocrinology 137:281-286
8. Gniadecki R, Gajkowska B, Hansen M (1997) 1,25-dihydroxyvitamin D3 stimulates the assembly of adherens junctions in keratinocytes: involvement of protein kinase C. Endocrinology 138:2241-2248
9. Kazan, RB, Kang L, Roe S, Borgen PI, Rimm DL (1997) Vinculin is associated with the E-cadherin adhesion complex. J Biol Chem 272:32448-32453
10. Hirano S, Nose A, Hatta K, Kawakami A, Takeichi M (1987) Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles. J Cell Biol 105:2501-2510
11. Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M (1992) Identification of a neural a-catenin as a key regulator of cadherin function and multicellular organization. Cell 70:293-301
12. Huber O, Bierkamp C, Kemler R (1996) Cadherins and catenins in development. Curr Opin Cell Biol 8:685-691
13. Jockusch BM, Rüdiger M (1996) Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation. Trends Cell Biol 6:311-314
14. Kanatani M, Sugimoto T, Fukase M, Chihara K (1993) Effect of 1,25-dihydroxyvitamin D3 on the proliferation of osteoblastic MC3T3-E1 cells by modulating the release of local regulators from monocytes. Biochem Biophys Res Commun 190:529-535
15. Klaushofer K, Varga F, Glantschnig H, Fratzl-Zelman N, Czerwenka E, Leis HJ, Koller K, Peterlik M (1995) The regulatory role of thyroid hormones in bone cell growth and differentiation. J Nutr 125:1996S-2003S
16. Knudsen KA, Wheelock MJ (1992) Plakoglobin, or an 83-kd homologue distinct from β-catenin, interacts with E-cadherin and N-cadherin. J Cell Biol 118:671-679
17. 3 on osteoblastic MC3T3-E1 cells. Endocrinology 118:940-947
18. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T. Nature 227:680-685
19. Lampugnani MG, Dejana E (1997) Interendothelial junctions: structure, signalling and functional roles. Curr Opin Cell Biol 9:674-682
20. Lampugnani MG, Corada M, Caveda L, Breviario F, Ayalon O, Geiger B, Dejana E (1995) The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, β-catenin, and α-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 129:203-217
21. Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (1997) Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sci 110:2065-2077
22. Luegmayr E, Varga F, Frank T, Roschger P, Klaushofer K (1996) Effects of triiodothyronine on morphology, growth behaviour, and the actin cytoskeleton in mouse osteoblastic cells (MC3T3-E1). Bone 18:591-599
23. Mathur M, Goodwin L, Cowin P (1994) Interactions of the cytoplasmic domain of the desmosomal cadherin DsgI with plakoglobin. J Biol Chem 269:14075-14080
24. Mbalaviele G, Chen H, Boyce FB, Mundy GR, Yoneda T (1995) The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. J Clin Invest 95:2757-2765
25. Mbalaviele G, Nishimura R, Myoi A, Niewolna M, Reddy SV, Chen D, Feng J, Roodman D, Mundy GR, Yoneda T (1998) Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation. J Cell Biol 141:1467-1476
26. Menkel AR, Kroemker M, Bubeck P, Ronsiek M, Nikolai G, Jockusch BM (1994) Characterization of an f-actin-binding domain in the cytoskeletal protein vinculin. J Cell Biol 126: 1231-1240
27. Nagafuchi A, Takeichi M, Tsukita S (1991) The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell 65:849-857
28. Nagafuchi A, Ishihara S, Tsukita S (1994) The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-α catenin fusion molecules. J Cell Biol 127:235-245
29. Ozawa M, Baribault H, Kemler R (1989) The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 8:1711-1717
30. Palka HL, Green KJ (1997) Roles of plakoglobin end domains in desmosome assembly. J Cell Sci 110:2359-2371
31. Palumbo C, Palazzini S, Marotti G (1990) Morphological study of intercellular junctions during osteocyte differentiation. Bone 11:401-406
32. Pötter E, Bergwitz C, Brabant G (1999) The cadherin-catenin system: implications for growth and differentiation of endocrine tissues. Endocrine Rev 20:207-239
33. Quarles LD, Yohay DA, Lever LW, Caton R, Wenstrup RJ (1992) Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J Bone Miner Res 7:683-692
34. Ruiz P, Brinkmann V, Ledermann B, Behrend M, Grund C, Thalhammer C, Vogel F, Birchmeier C, Gunthert U, Franke WW, Birchmeier W (1996) Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol 135:215-225
35. Steinberg MS (1996) Adhesion in development: an historical overview. Dev Biol 180:377-388
36. Sudo H, Kodama H, Amagai Y, Yamamoto S, Kasai S (1983) In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96:191-198
37. Takeichi M (1991) Cadherin cell adhesion receptors as morphogenetic regulator. Science 251:1451-1455
38. Tsutsumimoto T, Kawasaki S, Ebara S, Takaoka K (1999) TNF-α and IL-1β suppress N-cadherin expression in MC3T3-E1 cells. J Bone Miner Res 14:1751-1760
39. Varga F, Rumpler M, Luegmayr E, Fratzl-Zelman N, Glantschnig H, Klaushofer K (1997) Triiodothyronine a regulator of osteoblastic differentiation: depression of histone-H4, attenuation of c-fos/c-jun and induction of osteocalcin expression. Calcif Tissue Int 61:404-411
40. Varga F, Luegmayr E, Fratzl-Zelman N, Glantschnig H, Ellinger A, Prinz D, Rumpler M, Klaushofer K (1999) Tri-iodothyronine inhibits multilayer formation of the osteoblastic cell line, MC3T3-E1, by promoting apoptosis. J Endocrinology 160:57-65
41. Weiss EE, Kroemker M, Rüdiger AK, Jockusch BM, Rüdiger M (1998) Vinculin is part of the cadherin-catenin junctional complex: complex formation between α-catenin and vinculin. J Cell Biol 141:755-764