메뉴 건너뛰기




Volumn 12, Issue 7, 2000, Pages 2273-2280

Pituitary adenylate cyclase-activating polypeptide promotes the survival of basal forebrain cholinergic neurons in vitro and in vivo: Comparison with effects of nerve growth factor

Author keywords

Development; Fimbria fornix; NGF; PACAP; Rat septal neurons; Survival

Indexed keywords

CHOLINE ACETYLTRANSFERASE; DRUG VEHICLE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MESSENGER RNA; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; PROTEIN P75;

EID: 0033944825     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00118.x     Document Type: Article
Times cited : (57)

References (48)
  • 1
    • 84914639435 scopus 로고
    • Estimation of nuclear population from microtome sections
    • Abercrombie, M. (1946) Estimation of nuclear population from microtome sections. Anat. Rec., 94, 239-247.
    • (1946) Anat. Rec. , vol.94 , pp. 239-247
    • Abercrombie, M.1
  • 2
    • 0025168085 scopus 로고
    • Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
    • Alderson, R.F., Alterman, A.L., Barde, Y.-A. & Lindsay, R.M. (1990) Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron, 5, 297-306.
    • (1990) Neuron , vol.5 , pp. 297-306
    • Alderson, R.F.1    Alterman, A.L.2    Barde, Y.-A.3    Lindsay, R.M.4
  • 4
    • 0026593319 scopus 로고
    • Pituitary adenylate cyclase activating polypeptide (PACAP): Discovery and current status of research
    • Arimura, A. (1992) Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul. Pept., 37, 287-303.
    • (1992) Regul. Pept. , vol.37 , pp. 287-303
    • Arimura, A.1
  • 5
    • 0028020027 scopus 로고
    • Age-related vulnerability of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus
    • Burke, M.A., Apter, J.R., Wainer, B.H., Mufson, E.J. & Kordower, J.H. (1994) Age-related vulnerability of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus. Exp. Neural., 28,159-171.
    • (1994) Exp. Neural. , vol.28 , pp. 159-171
    • Burke, M.A.1    Apter, J.R.2    Wainer, B.H.3    Mufson, E.J.4    Kordower, J.H.5
  • 7
    • 0025967792 scopus 로고
    • Choline acetyltransferase messenger RNA expression in developing and adult rat brain: Regulation by nerve growth factor
    • Cavicchioli, L., Flanigan, T.P., Dickson, J.G., Vantini, G., Dal Toso, R., Fusco, M., Walsh, F.S. & Leon, A. (1991) Choline acetyltransferase messenger RNA expression in developing and adult rat brain: regulation by nerve growth factor. Mol. Brain Res., 9, 319-325.
    • (1991) Mol. Brain Res. , vol.9 , pp. 319-325
    • Cavicchioli, L.1    Flanigan, T.P.2    Dickson, J.G.3    Vantini, G.4    Dal Toso, R.5    Fusco, M.6    Walsh, F.S.7    Leon, A.8
  • 8
    • 0030799383 scopus 로고    scopus 로고
    • Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits
    • Chen, K.S., Nishimura, M.C., Armani, M.P., Crowley, C., Spencer, S.D. & Phillips, H.S. (1997) Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J. Neurosci., 17, 7288-7296.
    • (1997) J. Neurosci. , vol.17 , pp. 7288-7296
    • Chen, K.S.1    Nishimura, M.C.2    Armani, M.P.3    Crowley, C.4    Spencer, S.D.5    Phillips, H.S.6
  • 9
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by guanididium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by guanididium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 10
    • 0029994286 scopus 로고    scopus 로고
    • Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early development in the rat
    • Cooper, J.D., Skepper, J.N., Berzaghi, M.P., Lindholm, D. & Sofroniew, M.V. (1996) Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early development in the rat. Exp. Neurol., 139, 143-155.
    • (1996) Exp. Neurol. , vol.139 , pp. 143-155
    • Cooper, J.D.1    Skepper, J.N.2    Berzaghi, M.P.3    Lindholm, D.4    Sofroniew, M.V.5
  • 12
    • 0030053336 scopus 로고    scopus 로고
    • Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain
    • D'Agata, V., Cavallaro, S., Stivala, F. & Canonico, P.L. (1996) Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain. Eur. J. Neurosci., 8, 310-318.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 310-318
    • D'Agata, V.1    Cavallaro, S.2    Stivala, F.3    Canonico, P.L.4
  • 13
    • 0026660275 scopus 로고
    • The 38-amino acid form of pituitary adenylate cyclase-aetivating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth
    • Deutsch, P.J. & Sun, Y. (1992) The 38-amino acid form of pituitary adenylate cyclase-aetivating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth. J. Biol. Chem., 267, 5108-5113.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5108-5113
    • Deutsch, P.J.1    Sun, Y.2
  • 14
    • 0030761205 scopus 로고    scopus 로고
    • A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo
    • Pagan, A.M., Garber, M., Barbacid, M., Silos-Santiago, I. & Holzmann, D.M. (1997) A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J. Neurosci., 17, 7644-7654.
    • (1997) J. Neurosci. , vol.17 , pp. 7644-7654
    • Pagan, A.M.1    Garber, M.2    Barbacid, M.3    Silos-Santiago, I.4    Holzmann, D.M.5
  • 15
    • 0023835556 scopus 로고
    • Morphological response of axotomized septal neurons to nerve growth factor
    • Gage, F.H., Armstrong, D.M., Williams, L.R. & Varon, S. (1988) Morphological response of axotomized septal neurons to nerve growth factor. J. Comp. Neural., 269, 147-155.
    • (1988) J. Comp. Neural. , vol.269 , pp. 147-155
    • Gage, F.H.1    Armstrong, D.M.2    Williams, L.R.3    Varon, S.4
  • 16
    • 0000353840 scopus 로고
    • Distribution and molecular characterization of pituitary adenylate cyclase-activating polypeptide and its precursor encoding mRNA in human and rat tissues
    • Ghatei, M.A., Takahashi, K., Suzuki, Y., Gardiner, J., Jones, P.M. & Bloom, S.R. (1993) Distribution and molecular characterization of pituitary adenylate cyclase-activating polypeptide and its precursor encoding mRNA in human and rat tissues. J. Endocrinol., 134, 33-41.
    • (1993) J. Endocrinol. , vol.134 , pp. 33-41
    • Ghatei, M.A.1    Takahashi, K.2    Suzuki, Y.3    Gardiner, J.4    Jones, P.M.5    Bloom, S.R.6
  • 17
    • 9444281442 scopus 로고    scopus 로고
    • Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: An in situ hybridization study
    • Hashimoto, H., Nogi, H., Mori, K., Ohishi, H., Sigemoto, R., Yamamoto, K., Matsuda, T., Mizuno, N., Nagata, S. & Baba, A. (1996) Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: an in situ hybridization study. J. Comp. Neural., 371, 567-577.
    • (1996) J. Comp. Neural. , vol.371 , pp. 567-577
    • Hashimoto, H.1    Nogi, H.2    Mori, K.3    Ohishi, H.4    Sigemoto, R.5    Yamamoto, K.6    Matsuda, T.7    Mizuno, N.8    Nagata, S.9    Baba, A.10
  • 18
    • 0023839148 scopus 로고
    • Developmental change in nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats
    • Hatanaka, H., Tsuku, H. & Nihonmatsu, I. (1988) Developmental change in nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats. Dev. Brain Res., 39, 85-95.
    • (1988) Dev. Brain Res. , vol.39 , pp. 85-95
    • Hatanaka, H.1    Tsuku, H.2    Nihonmatsu, I.3
  • 19
    • 0021955153 scopus 로고
    • Nerve growth factor (NGF) increases choline acetyltransferase but not survival or fiber growth of cultured septal cholinergic neurons
    • Hefti, F., Hartikka, J., Eckenstein, F., Gnahn, H., Heumann, R. & Schwab, M. (1985) Nerve growth factor (NGF) increases choline acetyltransferase but not survival or fiber growth of cultured septal cholinergic neurons. Neuroscience, 14, 55-68.
    • (1985) Neuroscience , vol.14 , pp. 55-68
    • Hefti, F.1    Hartikka, J.2    Eckenstein, F.3    Gnahn, H.4    Heumann, R.5    Schwab, M.6
  • 20
    • 0022486717 scopus 로고
    • Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbria transaction
    • Hefti, F. (1986) Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbria transaction. J. Neurosci., 6, 2155-2162.
    • (1986) J. Neurosci. , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 21
    • 0031468496 scopus 로고    scopus 로고
    • Bcl-2 regulates the levels of the cystein proteases ICH and CPP32/Yama in human neuronal progenitor cells
    • Korhonen, L., Hamner, S., Olsson, P.A. & Lindholm, D. (1997) Bcl-2 regulates the levels of the cystein proteases ICH and CPP32/Yama in human neuronal progenitor cells. Eur. J. Neurosci., 9, 2489-2496.
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 2489-2496
    • Korhonen, L.1    Hamner, S.2    Olsson, P.A.3    Lindholm, D.4
  • 22
    • 0023067115 scopus 로고
    • Nerve growth factor treatment after brain injury prevents neuronal death
    • Kromer, L.F. (1987) Nerve growth factor treatment after brain injury prevents neuronal death. Science, 235, 214-216.
    • (1987) Science , vol.235 , pp. 214-216
    • Kromer, L.F.1
  • 23
    • 0028057458 scopus 로고
    • Brain derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons
    • Leingärtner, A., Heisenberg, C.-P., Kolbeck, R., Thoenen, H. & Lindholm, D. (1994) Brain derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. J. Biol. Chem., 269, 828-830.
    • (1994) J. Biol. Chem. , vol.269 , pp. 828-830
    • Leingärtner, A.1    Heisenberg, C.-P.2    Kolbeck, R.3    Thoenen, H.4    Lindholm, D.5
  • 24
    • 0028123267 scopus 로고
    • Fibroblast growth factor-5 promotes differentiation of cultured rat cholinergic and raphe dopaminergic neurons: Comparison with the effects of neurotrophins
    • Lindhohn, D., Hartikka, J., Berzaghi, M.P., Castrén, E., Tzimagiorgos, G., Hughes, R.A. & Thoenen, H. (1994) Fibroblast growth factor-5 promotes differentiation of cultured rat cholinergic and raphe dopaminergic neurons: comparison with the effects of neurotrophins. Eur. J. Neurosci., 6, 244-252.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 244-252
    • Lindhohn, D.1    Hartikka, J.2    Berzaghi, M.P.3    Castrén, E.4    Tzimagiorgos, G.5    Hughes, R.A.6    Thoenen, H.7
  • 25
    • 0029998442 scopus 로고    scopus 로고
    • Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4
    • Lindholm, D., Carroll, P., Tzimagiorgios, G. & Thoenen, H. (1996) Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. Eur. J. Neurosci., 8, 1452-1460.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1452-1460
    • Lindholm, D.1    Carroll, P.2    Tzimagiorgios, G.3    Thoenen, H.4
  • 27
    • 2642640418 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-aetivating polypeptide (PACAP) protects dorsal root ganglion neurons from death and induces calcitonin gene-related peptide (CGRP) immunoreactivity in vitro
    • Lioudyno, M., Skoglösa, Y., Takei, N. & Lindholm, D. (1998) Pituitary adenylate cyclase-aetivating polypeptide (PACAP) protects dorsal root ganglion neurons from death and induces calcitonin gene-related peptide (CGRP) immunoreactivity in vitro. J. Neurosci. Res., 51, 243-256.
    • (1998) J. Neurosci. Res. , vol.51 , pp. 243-256
    • Lioudyno, M.1    Skoglösa, Y.2    Takei, N.3    Lindholm, D.4
  • 28
    • 0031004584 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells
    • Lu, N. & DiCicco-Bloom, E. (1997) Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells. Proc. Natl Acad. Sci. USA, 94, 3357-3362.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3357-3362
    • Lu, N.1    DiCicco-Bloom, E.2
  • 29
    • 0026539332 scopus 로고
    • Binding sites for pituitary adenylate cyclase activating polypeptide (PACAP): Comparison with vasoactive intestinal polypeptide (VIP) binding site localization in rat brain sections
    • Masuo, Y., Ohtaki, T., Masuda, Y., Tsuda, M. & Fujino, M. (1992) Binding sites for pituitary adenylate cyclase activating polypeptide (PACAP): comparison with vasoactive intestinal polypeptide (VIP) binding site localization in rat brain sections. Brain Res., 575, 113-123.
    • (1992) Brain Res. , vol.575 , pp. 113-123
    • Masuo, Y.1    Ohtaki, T.2    Masuda, Y.3    Tsuda, M.4    Fujino, M.5
  • 30
    • 0027476845 scopus 로고
    • Regional distribution of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat central nervous system as determined by sandwich-enzyme immunoassay
    • Masuo, Y., Suzuki, N., Matsumoto, H., Tokito, F., Matsumoto, Y., Tsuda, M. & Fujino, M. (1993) Regional distribution of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat central nervous system as determined by sandwich-enzyme immunoassay. Brain Res., 602, 57-63.
    • (1993) Brain Res. , vol.602 , pp. 57-63
    • Masuo, Y.1    Suzuki, N.2    Matsumoto, H.3    Tokito, F.4    Matsumoto, Y.5    Tsuda, M.6    Fujino, M.7
  • 31
    • 0002318588 scopus 로고
    • Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons
    • Mobley, W.C., Rutkowski, J.L., Tennekoon, G.J., Gemski, J., Buchanan, K. & Johnston, M.V. (1986) Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Mol. Brain Res., 1, 53-62.
    • (1986) Mol. Brain Res. , vol.1 , pp. 53-62
    • Mobley, W.C.1    Rutkowski, J.L.2    Tennekoon, G.J.3    Gemski, J.4    Buchanan, K.5    Johnston, M.V.6
  • 32
    • 0030602003 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide protects rat cultured cortical neurons from glutamate-induced cytotoxicity
    • Morio, H., Tatsuno, I., Hirai, A., Tamura, Y. & Saito, Y. (1996) Pituitary adenylate cyclase-activating polypeptide protects rat cultured cortical neurons from glutamate-induced cytotoxicity. Brain Res., 741, 82-88.
    • (1996) Brain Res. , vol.741 , pp. 82-88
    • Morio, H.1    Tatsuno, I.2    Hirai, A.3    Tamura, Y.4    Saito, Y.5
  • 34
    • 0025166652 scopus 로고
    • Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: Evidence for the death of cholinergic and noncholinergic neurons
    • O'Brien, T.S., Svendsen, C.N., Isacson, O. & Sofroniew, M.V. (1990) Loss of True blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and noncholinergic neurons. Brain Res., 508, 249-256.
    • (1990) Brain Res. , vol.508 , pp. 249-256
    • O'Brien, T.S.1    Svendsen, C.N.2    Isacson, O.3    Sofroniew, M.V.4
  • 35
    • 0033586402 scopus 로고    scopus 로고
    • Presynaptic localization of the PACAP-typeI-receptor in hippocampal and cerebellar mossy fibers
    • Otto, C., Zuschratter, W., Gass, P. & Schutz, G. (1999) Presynaptic localization of the PACAP-typeI-receptor in hippocampal and cerebellar mossy fibers. Mol. Brain. Res., 66, 163-174.
    • (1999) Mol. Brain. Res. , vol.66 , pp. 163-174
    • Otto, C.1    Zuschratter, W.2    Gass, P.3    Schutz, G.4
  • 36
    • 0029925683 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by neurotrophic factors
    • Segal, R.A. & Greenberg, M.E. (1997) Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci., 19, 463-489.
    • (1997) Annu. Rev. Neurosci. , vol.19 , pp. 463-489
    • Segal, R.A.1    Greenberg, M.E.2
  • 37
    • 0033582594 scopus 로고    scopus 로고
    • Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain
    • Skoglösa, Y., Takei, N. & Lindholm, D. (1999a) Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain. Mol. Brain Res., 65, 1-13.
    • (1999) Mol. Brain Res. , vol.65 , pp. 1-13
    • Skoglösa, Y.1    Takei, N.2    Lindholm, D.3
  • 38
    • 0345320465 scopus 로고    scopus 로고
    • Regulation of of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: Comparison with brain-derived neurotriphic factor and the induction of neuronal cell death
    • Skoglösa, Y., Lewén, A., Takei, N., Hillered, L. & Lindholm, D. (1999b) Regulation of of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: comparison with brain-derived neurotriphic factor and the induction of neuronal cell death. Neuroscience, 90, 235-247.
    • (1999) Neuroscience , vol.90 , pp. 235-247
    • Skoglösa, Y.1    Lewén, A.2    Takei, N.3    Hillered, L.4    Lindholm, D.5
  • 39
    • 0028331599 scopus 로고
    • Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    • Smeyne, R.J., Klein, R., Schnapp, A., Long, L.K., Bryant, S., Lewin, A., Lira, S.A. & Barbacid, M. (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature, 368, 246-249.
    • (1994) Nature , vol.368 , pp. 246-249
    • Smeyne, R.J.1    Klein, R.2    Schnapp, A.3    Long, L.K.4    Bryant, S.5    Lewin, A.6    Lira, S.A.7    Barbacid, M.8
  • 40
    • 0025136826 scopus 로고
    • Survival of adult basal forebrain cholinergic neurons after loss of target neurons
    • Sofroniew, M.V., Galletly, N.P., Isacson, O. & Svendsen, C.N. (1990) Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science, 247, 338-342.
    • (1990) Science , vol.247 , pp. 338-342
    • Sofroniew, M.V.1    Galletly, N.P.2    Isacson, O.3    Svendsen, C.N.4
  • 41
    • 0027134807 scopus 로고
    • Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF and NT-3
    • Sofroniew, M.V., Cooper, J.D., Svendsen, C.N., Crossman, P., Ip, N.Y., Lindsay, R.M., Zafra, F. & Lindholm, D. (1993) Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF and NT-3. J. Neurosci., 13, 5263-5276.
    • (1993) J. Neurosci. , vol.13 , pp. 5263-5276
    • Sofroniew, M.V.1    Cooper, J.D.2    Svendsen, C.N.3    Crossman, P.4    Ip, N.Y.5    Lindsay, R.M.6    Zafra, F.7    Lindholm, D.8
  • 43
    • 0028120897 scopus 로고
    • Death of developing septal cholinergic neurons following NGF withdrawal in vitro: Protection by protein synthesis inhibition
    • Svendsen, C.N., Kew, J.N.C., Staley, K. & Sofroniew, M.V. (1994) Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J. Neurosci., 14, 75-87.
    • (1994) J. Neurosci. , vol.14 , pp. 75-87
    • Svendsen, C.N.1    Kew, J.N.C.2    Staley, K.3    Sofroniew, M.V.4
  • 44
    • 0032401022 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic dopaminergic neurons
    • Takei, N., Skoglösa, Y. & Lindholm, D. (1998) Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic dopaminergic neurons. J. Neurosci. Res., 54, 698-706.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 698-706
    • Takei, N.1    Skoglösa, Y.2    Lindholm, D.3
  • 45
    • 0026634305 scopus 로고
    • Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide increase cytosolic free calcium concentration in cultured rat hippocampal neurons
    • Tatsuno, I., Yada, T., Vigh, S., Hidaka, H. & Arimura, A. (1992) Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide increase cytosolic free calcium concentration in cultured rat hippocampal neurons. Endocrinology, 131, 73-78.
    • (1992) Endocrinology , vol.131 , pp. 73-78
    • Tatsuno, I.1    Yada, T.2    Vigh, S.3    Hidaka, H.4    Arimura, A.5
  • 46
    • 0025061139 scopus 로고
    • Basal forebrain cell loss following fimbria/fornix transection
    • Tuszynski, M.H., Armstrong, D.M. & Gage, F.H. (1990) Basal forebrain cell loss following fimbria/fornix transection. Brain Res., 508, 241-248.
    • (1990) Brain Res. , vol.508 , pp. 241-248
    • Tuszynski, M.H.1    Armstrong, D.M.2    Gage, F.H.3
  • 47
    • 0031027331 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway
    • Villalba, M., Bockaert, J. & Journot, L. (1997) Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J. Neurosci., 17, 83-90.
    • (1997) J. Neurosci. , vol.17 , pp. 83-90
    • Villalba, M.1    Bockaert, J.2    Journot, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.