Enhancement of persistent Na+ current by sea anemone toxin (ATX II) exerts dual action on hippocampal excitability

European Journal of Neuroscience

Volumn 12, Issue 7, 2000, Pages 2387-2396

  Brand, Sabine ^a   Seeger, Thomas ^a   Alzheimer, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Persistent sodium current; Rat hippocampus; Sea anemone toxin

Indexed keywords

SEA ANEMONE TOXIN; SODIUM; SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ELECTRODE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; NERVE CELL NETWORK; NERVE EXCITABILITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SENSORY NERVE; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; CNIDARIAN VENOMS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; NEURONS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; PERIODICITY; RATS; RATS, WISTAR; SODIUM; SODIUM CHANNELS;

EID: 0033941469     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00136.x     Document Type: Article

References (24)

1. Alger, B.A. (1984) Hippocampus - electrophysiological studies of epileptiform activity in vitro. In Dingledine, R. (ed), Brain Slices. Plenum, New York, pp. 155-199.
2. Alkadhi, K.A. & Tian, L.-M. (1996) Veratridine-enhanced persistent sodium current induces bursting in CA1 pyramidal neurons. Neuroscience, 71, 625-632.
3. Alroy, G., Su, H. & Yaari, Y. (1999) Protein kinase C mediates muscarinic block of intrinsic bursting in rat hippocampal neurons. J. Physiol. (Lond.), 518, 71-79.
4. + current in pyramidal neurons from rat and cat sensorimotor cortex. J. Neurosci., 13, 660-673.
5. Alzheimer, C., Sutor, B. & ten Bruggencate, G. (1993b) Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: pre-and postsynaptic components. Neuroscience, 57, 565-575.
6. Azouz, R., Jensen, M.S. & Yaari, Y. (1996) Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J. Physiol. (Lond.), 492, 211-231.
7. + channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis. J. Physiol. (Lond.), 466, 501-520.
8. Cannon, S.C. & Strittmatter, S.M. (1993) Functional expression of sodium channel mutations identified in families with periodic paralysis. Neuron, 10, 317-326.
9. Cannon, S.C. (1996) Ion-channel defects and aberrant excitability in myotonia and periodic paralysis. Trends Neurosci., 19, 3-10.
10. Catterall, W.A. (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev., 72, S15-S48.
11. Chahine, M., Plante, E. & Kallen, R.G. (1996) Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel α-subunits expressed in tsA201 cells. J. Membr. Biol., 152, 39-48.
12. + current of mammalian CNS neurones. Neuroreport, 6, 1778-1780.
13. Crill, W.E. (1996) Persistent sodium current in mammalian central neurons. Annu. Rev. Physiol., 58, 349-362.
14. El-Sherif, N., Fozzard, H.A. & Hanck, D.A. (1992) Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATX II. Circ. Res., 70, 285-301.
15. Franceschetti, S., Guatteo, E., Panzica, F., Sancini, G., Wanke, E. & Avanzini, G. (1995) Ionic mechanisms underlying burst firing in pyramidal neurons: intracellular study in rat sensorimotor cortex. Brain Res., 696, 127-139.
16. Hayward, L.J., Brown Jr, R.H. & Cannon, S.C. (1996) Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker. J. Gen. Physiol., 107, 559-576.
17. Hille, B. (1992) Ionic Currents of Excitable Membranes. Sinauer Associates Inc., Sunderland, MA, USA.
18. + current. J. Pharmacol. Exp. Ther., 284, 228-237.
19. + current in entorhinal cortex neurons. J. Neurosci., 19, 7334-7341.
20. Mantegazza, M., Franceschetti, S. & Avanzini, G. (1998). Anemone toxin (ATX II) -induced increase in persistent sodium current: effects on the firing properties of rat neocortical pyramidal neurones. J. Physiol. (Lond.), 507, 105-116.
21. Mitrovic, N., George, A.L., Lerche, H., Wagner, S., Fahlke, C. & Lehmann-Horn, F. (1995) Different effects on gating of three myotonia-causing mutations in the inactivation gate of the human muscle sodium channel. J. Physiol. (Lond.), 487, 107-114.
22. Roden, D.M., George Jr, A.L. & Bennett, P.B. (1995) Recent advances in understanding the molecular mechanisms of the long QT syndrome. J. Cardiovasc. Electrophysiol., 6, 1023-1031.
23. Segal, M.M. & Douglas, A.F. (1997) Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin. J. Neurophysiol., 77, 3021-3034.
24. + channel subtypes in central neurons. Neuron, 3, 695-704.