Pharmacokinetics of nitazoxanide after single oral dose administration in 6 healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics

Volumn 34, Issue 8, 1996, Pages 349-351

  Stockis, A ^a   Deroubaix, X ^a   Lins, R ^a   Jeanbaptiste, B ^a   Calderon, P ^a   Rossignol, J F ^b  

^a Bio Pharma SA   (Belgium)

^b Romark Laboratories   (United States)

Author keywords

Antiprotozoal; Bioavailability in man; Nitazoxanide; Pharmacokinetics

Indexed keywords

ACETYLSALICYLIC ACID; ANTIPROTOZOAL AGENT; DRUG METABOLITE; ESTERASE; GENTISIC ACID; NITAZOXANIDE; PARACETAMOL; SALICYLIC ACID; SALICYLURIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG PROTEIN BINDING; DRUG URINE LEVEL; FOOD INTAKE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PLASMA PROTEIN BINDING; TACHYCARDIA;

ADMINISTRATION, ORAL; ADULT; ANTIPROTOZOAL AGENTS; HUMANS; MALE; THIAZOLES;

EID: 0029745128     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Doumbo O, Rossignol JF, Pichard E, Traore H, Dembele M, Diakite M, Traore F, Diallo AD 1996 Nitazoxanide in the treatment of crypto- sporidiosis in 24 AIDS patients with chronic diarrhea in Mali. Am J Trop Med Hyg (in press)
2. Gibaldi M, Perrier D 1982 Pharmacokinetics. 2nd edn, Marcel Dekker, New York
3. Kabil SM, Abd El-Salam F, Nassar AK, Abd El-Bast M 1994 Effects of nitazoxanide on the treatment of common human helminthic and protozoal infections. J Trop Med (Egypt) 3: 7-10
4. Rossignol JF, Cavier R (1976) New derivatives of 2-benzamido 5-nitrothiazoles. United States patent No, 3,950,351, April 13
5. Rossignol JF, Maisonneuve H 1984 Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana. Am J Trop Med Hyg 33: 511-512
6. Williams F, Wynne H, Woodhouse K, Rawlins M 1989 Plasma aspirin esterase: the influence of old age and frailty. Age Ageing 18: 39-42