Genetics of atopy in a mouse model: Polymorphism of the IL-5 receptor α chain

Immunogenetics

Volumn 51, Issue 8-9, 2000, Pages 632-638

  Daser, Angelika ^a   Koetz, Karsten ^a   Bätjer, Nina ^a   Jung, Martin ^b,f   Rüschendorf, Franz ^b   Goltz, Michael ^c   Ellerbrok, Heinz ^c   Renz, Harald ^a,e   Walter, Joern ^d   Paulsen, Martina ^d,g  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Bioinfo and Gene Mapping Centre   (Germany)

^c ROBERT KOCH INSTITUTE   (Germany)

^d MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

^f Ingenium Pharmaceuticals AG   (Germany)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Alternative splicing; Atopy; Genetics; Interleukin 5 receptor; Polymorphism

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 5 RECEPTOR; MESSENGER RNA; MICROSATELLITE DNA; POLLEN ANTIGEN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; ATOPY; CELL SURFACE; CHROMOSOME 6; CONTROLLED STUDY; ECZEMA; FEMALE; GENE CONSTRUCT; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SCREENING; IMMUNE RESPONSE; INBRED STRAIN; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; RNA TRANSCRIPTION; RNA TRANSLATION; SKIN TEST;

ALTERNATIVE SPLICING; ANIMALS; CELL MEMBRANE; CHIMERA; CHROMOSOME MAPPING; CROSSES, GENETIC; CYTOPLASM; DISEASE MODELS, ANIMAL; GENOTYPE; HYPERSENSITIVITY, IMMEDIATE; LINKAGE (GENETICS); MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHENOTYPE; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-5; RNA, MESSENGER;

ANIMALIA;

EID: 0033936653     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510000206     Document Type: Article

References (39)

1. Anderson GG, Cookson WO (1999) Recent advances in the genetics of allergy and asthma. Mol Med Today 5:264-273
2. Baltus B, van Dijk TB, Caldenhoven E, Zanders E, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP (1998) An AP-1 site in the promoter of the human IL-5R alpha gene is necessary for promoter activity in eosinophilic HL60 cells.FEBS Lett 434:251-254
3. Brown PM, Tagari P, Rowan KR, Yu VL, O'Neill GP, Middaugh CR, Sanyal G, Ford-Hutchinson AW, Nicholson DW (1995) Epitope-labeled soluble human interleukin-5 (IL-5) receptors. Affinity cross-link labeling, IL-5 binding, and biological activity. J Biol Chem 270:29236-2943
4. Chatila TA (1998) Genetics of atopic diseases. Curr Opin Pediatr 10:584-587
5. Cookson W (1999) The alliance of genes and environment in asthma and allergy. Nature 402: suppl B5-B11
6. Daser A, Meissner N, Herz U, Renz H (1995) Role and modulation of T-cell cytokines in allergy. Curr Opin Immunol 7:762-770
7. Daser A, Bätjer N, Kölsch U, Kötz K, Schmeling H, Schou C, Renz H (1998) Quantitative assessment of immediate cutaneous hypersensitivity in a model of genetic predisposition to atopy. Int Arch Allergy Immunol 117:239-243
8. Daser A, Mitchison H, Mitchison NA, Mueller B (1996) Non-classical MHC genetics of immunological diseases in man and mouse. The key role of proinflammatory cytokines. Cytokine 8:593-597
9. DeSanctis G, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM (1995) Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6 mice. Nat Genet 11:150-154
10. Devos R, Guisez Y, Cornelis S, Verhee A, Van der Heyden J, Manneberg M, Lahm HW, Fiers W, Tavernier J, Plaetinck G (1993) Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5. J Biol Chem 268:6581-6587
11. Ewart SL, Mitzner W, DiSilvestre DA, Meyers DA, Levitt RCFalk K (1996) Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6. Am J Respir Cell Mol Biol 14:487-95
12. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 337:1720-1725
13. Hiroi T, Yanagita M, Iijima H, Iwatani K, Yoshida T, Takatsu K, Kiyono H (1999) Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. J Immunol 162:821-828
14. Imamura F, Takaki S, Akagi K, Ando M, Yamamura K, Takatsu K, Tominaga A (1994) The murine interleukin-5 receptor alpha-subunit gene: characterization of the gene structure and chromosome mapping. DNA Cell Biol 13:283-292
15. Kikuchi Y, Migita M, Takaki S, Tominaga A, Takatsu K (1994) Biochemical and functional characterization of soluble form of IL-5 receptor alpha (sIL-5R alpha). Development of ELISA system for detection of sIL-5R alpha. J Immunol Methods 167:289-298
16. Kim KJ, Kanellopoulos-Langevin C, Merwin RM, Sachs DH, Asofsky R (1979) Establishment and characterization of Balb/c lymphoma lines with B cell properties. J Immunol 122:549-554
17. Kozak M (1987) An analysis of 5′-non-coding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 15:8125-8148
18. Lander E, Green P, Abrahamson J, Barlow A, Daly M, Lincoln S, Newburg L (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174-181
19. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
20. Larsen JN, Sparholt SH, Ipsen H (1996) Epitope structure of recombinant isoallergens of Bet v1. J Adv Exp Med Biol 409:243-249
21. Lincoln S, Daly M, Lander E (1992a) Constructing genetic maps with MAPMAKER/EXP 3.0. Whitehead Institute Technical Report, 3rd edition
22. Lincoln S, Daly M, Lander E (1992b) Mapping genes controlling quantitative traits with MAPMAKER/QTL 1.1. Whitehead Institute Technical Report, 2nd edition
23. MacDonald RJ, Swift GH, Przybyla AE, Chirgwin JM (1987) Isolation of RNA using guanidinium salts. Methods Enzymol 152:219-227
24. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, Kawai M, Sasaki S, Dake Y, Hamasaki N, Shirakawa T, Hopkin JM (1998) Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 19:119-120
25. Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K (1992) Molecular cloning and expression of the human interleukin 5 receptor. J Exp Med 175:341-351
26. O'Garra A (1998) Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275-283
27. Paterson A, Lander E, Lincoln S, Hewitt J, Peterson S, Tanksley S (1988) Resolution of quantitative traits into mendelian factors using a complete RFLP linkage map. Nature 335:721-726
28. Reil H, Hauser H (1990) Test system for determination of HIV-1 frameshifting efficiency in animal cells. Biochim Biophys Acta 1050:288-292
29. Schalkwyk LC, Jung M, Daser A, Weiher M, Walter J, Himmelbauer H, Lehrach H (1999) Panel of microsatellite markers for whole-genome scans and radiation hybrid mapping and a mouse family tree. Genome Res 9:878-887
30. Snell GD (1978) Congenic resistant strains of mice. In: Origin of Inbred Mice. Academic Press, New York, pp 1-31
31. Sun Z, Yergeau DA, Wong IC, Tuypens T, Tavernier J, Paul CC, Baumann MA, Auron PE, Tenen DG, Ackerman SJ (1996) Interleukin-5 receptor alpha subunit gene regulation in human eosinophil development:identification of a unique cis-element that acts like an enhancer in regulating activity of the IL-5R alpha promoter. Curr Top Microbiol Immunol 211:173-187
32. Takaki S, Tominaga A, Hitoshi Y, Mita S, Sonoda E, Yamaguchi N, Takatsu K (1990) Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J 9:4367-4374
33. Takaki S, Murata Y, Kitamura T, Miyajima A, Tominaga A, Takatsu K (1993) Reconstitution of the functional receptors for murine and human interleukin 5. J Exp Med 177:1523-1529
34. Takatsu K (1998) Interleukin 5 and B cell differentiation. Cytokine Growth Factor Rev 9:25-35
35. Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G (1991) A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 66:1175-1184
36. Thomson G (1994) Identifying complex disease genes: progress and paradigms. Nat Genet 8:108-109
37. Tuypens T, Plaetinck G, Baker E, Sutherland G, Brusselle G, Fiers W, Devos R, Tavernier J (1992) Organization and chromosomal localization of the human interleukin 5 receptor α-chain gene. Eur Cytokine Netw 3:451-459
38. Yoshida T, Ikuta K, Sugaya H, Maki K, Takagi M, Kanazawa H, Sunaga S, Kinashi T, Yoshimura K, Miyazaki J, Takaki S, Takatsu K (1996) Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in 1L-5R alpha-deficient mice. Immunity 4:483-494
39. Zhang Y, Lefort J, Kearsey V, Lapa e Silva JR, Cookson WO, Vargaftig BB (1999) A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma. Hum Mol Genet 8:601-605