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Exposure to house-dust mite allergen (Der p 1) and the development of asthma in childhood
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Peat, J.K.1
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Lynch NR, Hagel IA, Palenque ME, et al.: Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 1998, 101:217-221. This article provides interesting and hard to come by human population data on the role of atopy in protecting from parasitic infections.
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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
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Noben-Trauth N, Shultz LD, Brombacher F, Urban JF, Gu H, Paul WE: An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A 1997, 94:10838-10843. This is an elegant demonstration of the pivotal role of the IL-4Rα in medaiting alledrgic responses.
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0028230946
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Linkage analysis of IL-4 and chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
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Marsh, D.G.1
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0028789831
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Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy
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Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ: Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995, 25:74-78.
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Molecular cloning of a cDNA encoding the human interleukin 4 receptor
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0030497506
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Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways
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Oakes SA, Candotti F, Johnston JA, et al.: Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. Immunity 1996, 5:605-615.
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0001325237
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The association of atopy with a gain-of-function mutation in the a subunit of the interleukin 4 receptor
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Hershey GKK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA: The association of atopy with a gain-of-function mutation in the a subunit of the interleukin 4 receptor. N Engl J Med 1997, 337:1720-1725. This study provides compelling data for the association of the IL-4Rα chain locus with atopy and asthma.
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Hershey, G.K.K.1
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Linkage and allelic association of atopy and markers flanking the IL4-receptor gene
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Mitsuyasu H, Izuhara K, Mao XQ, et al.: Ile50val variant of IL-4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998, 19:119-120. This study provides compelling data for the association of the IL-4Rα chain locus with atopy and asthma.
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Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy
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Dombrowicz D, Lin S, Flamand V, Brini AT, Koller BH, Kinet J-P: Allergy-associated FcRβ is a molecular amplifier of IgE and IgG-mediated in vivo responses. Immunity 1998, 8:517-529. This report elucidates the biologic function of this subunit and provides a rationale for its association with atopy.
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Dombrowicz, D.1
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Association between atopy and variants of the β subunit of the high affinity immunoglobulin e receptor
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Young, R.P.1
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Moffatt MF, Schou C, Faux J, Cookson WOCM: Germline TCR-A restriction of immunoglobulin E responses to allergen. Immunogenetics 1997, 46:266-230. This report complements previous data on the role of HLA class II molecules in atopy predisposition by demonstrating a similar predisposing effect of T-cell antigen receptor elements.
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Hum Mol Genet
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Moffatt, M.F.1
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