Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 6. Synthesis of a key intermediate via a highly efficient macrolactonization of a computer-aid designed seco-acid

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 6, 2000, Pages 855-860

  Matsushima, Tomohiro ^a   Nakajima, Noriyuki ^b   Zheng, Bao Zhong ^c   Yonemitsu, Osamu ^c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

Author keywords

18 membered lactone; Aldol reaction; Calculation; Macrolactonization; Macrolide; Seco acid

Indexed keywords

ACID; ANTINEOPLASTIC AGENT; LACTONE; MACROLIDE; TEDANOLIDE; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CYCLIZATION; DRUG CONFORMATION; DRUG SYNTHESIS; STEREOCHEMISTRY; TUMOR;

EID: 0033935260     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.855     Document Type: Article

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