Synthetic studies of the 18-membered antitumor macrolide, tedanolide. 3. Stereocontrolled synthesis of the C1-C12 part via a synthesis of the C1-C7 fragment by a mismatched but efficient sharpless dihydroxylation and its coupling with the C8-C11 fragment

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 3, 1999, Pages 308-321

  Matsushima, Tomohiro ^a   Mori, Michiko ^b   Zheng, Bao Zhong ^b   Maeda, Hiroshi ^b   Nakajima, Noriyuki ^c   Uenishi, Jun Ichi ^b   Yonemitsu, Osamu ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

^c TOYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

AD mix; Hydrozirconation; Macrolide; Sharpless dihydroxylation; Sharpless epoxidation; Sonication

Indexed keywords

ANTINEOPLASTIC AGENT; MACROLIDE; TEDANOLIDE; UNCLASSIFIED DRUG; ZIRCONIUM DERIVATIVE;

ARTICLE; COLUMN CHROMATOGRAPHY; DRUG SYNTHESIS; EPOXIDATION; HYDROXYLATION; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; ULTRASOUND;

EID: 0032894075     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.308     Document Type: Article

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