Development of a 3D pharmacophore for nonspecific ligand recognition of α1, α2, α3, α5, and α6 containing gaba(A)/benzodiazepine receptors

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 7, 2000, Pages 1799-1807

  Filizola, Marta ^a   Harris, Danni L ^a   Loew, Gilda H ^a  

^a MOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; LIGAND;

ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SYNTHESIS; LIGAND BINDING; METHODOLOGY; NONHUMAN; PHARMACOPHORE; RECEPTOR AFFINITY; RECOGNITION;

BENZODIAZEPINES; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN SUBUNITS; RECEPTORS, GABA-A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0033935070     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00112-7     Document Type: Article

References (32)

1. Mohler H., Okada T. Science. 198:1977;849.
2. Squires R.F., Braestrup C. Nature. 266:1977;732.
3. Langer S.Z., Arbilla S. Fund. Clin. Pharmacol. 2:1988;159.
4. Kirkham T.C., Cooper S.J. Pharmacol. Biochem. Behav. 26:1987;497.
5. Venault P., Chaouthier G., Prado de Carvalho L., Simiand J., Morre M., Dodd R.H., Rossier J. Nature. 321:1986;864.
6. A Receptor Family: Molecular and Functional Diversity; Cold Spring Harbor Symposia on Quantitative Biology: CSHL Press, New York, 1990; p 29.
7. Bonnert T.P., McKernan R.M., Ferrar S., le Bourdelles B., Heavens R.P., Smith D.W., Hewson L., Rigby M.R., Sirinathsinghji D.J., Brown N., Wafford K.A., Whiting P.J. Proc. Natl. Acad. Sci. USA. 96:1999;9891.
8. Olsen, R. W.; DeLorey, T. M. In Basic Neurochemistry; Siegel, G. J., Agranoff, B. W., Albers, R. W., Molinoff, P. B., Eds.; Raven: New York, 1999; p 335.
9. McKernan R.M., Whiting P.J. Trends Neurosci. 19:1996;139.
10. Prichett D.B., Sontheimer H., Shivers B.D., Ymer S., Kettenmann H., Schofield P.R., Seeburg P.H. Nature. 338:1989;582.
11. Siegel E., Baur R., Trube G., Mohler H., Malherbe P. Neuron. 5:1990;703.
12. Smith G.B., Olsen R.W. TIPS. 16:1995;162.
13. Prichett D.B., Luddens H., Seeburg P.H. Science. 245:1989;1389.
14. Wong G., Skolnick P. Pharmacol. Biochem. Behav. 42:1992;107.
15. Ebert B., Thompson S.A., Saounatsou K., McKernan R., Krogsgaard-Larsen P., Wafford K.A. Mol. Pharmacol. 52:1997;1150.
16. Vieth M., Hirst J.D., Brooks C.L. III J. Comp. Aid. Mol. Des. 12:1998;563.
17. Huang P., Kim S., Loew G. J. Comp. Aid. Mol. Des. 11:1997;21.
18. Wong G., Koehler K.F., Skolnick P., Gu Z.K., Ananthan S., Schonholzer P., Hunkeler W., Zhang W., Cook J.M. J. Med. Chem. 36:1993;1820.
19. Hempel A., Camerman N., Camerman A. Can. J. Chem. 65:1987;1608.
20. Bertolasi, V.; Ferretti, V.; Gilli, G.; Borea, P. A. J. Chem. Soc., Perkin Trans. 2 1990, 283.
21. Ananthan S., Clayton S.D., Ealick S.E., Wong G., Evoniuk G.E., Skolnick P. J. Med. Chem. 36:1993;479.
22. Watjen F., Baker R., Engelstoff M., Herbert R., MacLeod A., Knight A., Merchant K., Moseley J., Saunders J., Swain C.J., Wong E., Springer J.P. J. Med. Chem. 32:1989;2282.
23. Davies M.F., Onaivi E.S., Chen S.W., Maguire P.A., Tsai N.F., Loew G.H. Pharmacol. Biochem. Behav. 49:1994;47.
24. Chen S.W., Chen H.A., Davies M.F., Loew G.H. Pharmacol. Biochem. Behav. 53:1996;87.
25. Huang Q., Liu R., Zhang P., He X., McKernan R., Gan T., Bennett D.W., Cook J.M. J. Med. Chem. 41:1998;4130.
26. Hadingham K.L., Wingrove P., LeBourdelles B., Palmer K.J., Ragan C.I., Whiting P. J. Mol. Pharmacol. 43:1993;970.
27. Scholze P., Ebert V., Sieghart W. Eur. J. Pharmacol. 304:1996;155.
28. Hadingham K.L., Garrett E.M., Wafford K.A., Bain C., Heavens R.P., Sirinathsinghji D.J.S., Whiting P. J. Mol. Pharmacol. 49:1996;253.
29. Lameh, J.; Wang, P.; Meredith, D.; Shafer, S. L.; Loew, G. H. Progress in Neuro-Psychopharmacol. & Biol. Phychiatry 2000, in press.
30. Liu R., Zhang P., McKernan R.M., Wafford K., Cook J.M. Med. Chem. Res. 5:1995;700.
31. Quirk K., Blurton P., Fletcher S., Leeson P., Tang F., Melillo D., Ragan C.I., McKernan R.M. Neuropharmacology. 35:1996;1331.
32. Hadingham K.L., Harkness P.C., McKernan R.M., Quirk K., Le Bourdelles B., Horne A.L., Kemp J.A., Barnard E.A., Ragan C.I., Whiting P.J. Proc. Natl. Acad. Sci. USA. 89:1992;6378.