Chronic schistosomiasis: Dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness

Journal of Infectious Diseases

Volumn 182, Issue 1, 2000, Pages 260-265

  Van Den Biggelaar, Anita H J ^a   Grogan, Jane L ^a,c   Filié, Yvonne ^a   Jordens, Reina ^a   Kremsner, Peter G ^b   Koning, Frits ^a   Yazdanbakhsh, Maria ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; INTERLEUKIN 5; PARASITE ANTIGEN;

ADOLESCENT; ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HELPER CELL; HUMAN; IMMUNE RESPONSE; MALE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA HEMATOBIUM; SCHISTOSOMIASIS; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ADOLESCENT; ADULT; ANTIGEN-PRESENTING CELLS; CELL DIVISION; CHRONIC DISEASE; CYTOKINES; DENDRITIC CELLS; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-4; LYMPHOKINES; MALE; MONOCYTES; SCHISTOSOMIASIS; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 0033931803     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315662     Document Type: Article

References (37)

1. 1. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383:787-93.
2. 2. Stockinger B. T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv Immunol 1999; 71:229-65.
3. 3. Boni C, Bertoletti A, Penna A, et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest 1998; 102:968-75.
4. 4. Benard G, Mendes-Giannini MJ, Juvenale M, Miranda ET, Duarte AJ. Immunosuppression in paracoccidioidomycosis: T cell hyporesponsiveness to two Paracoccidioides brasiliensis glycoproteins that elicit strong humoral immune response. J Infect Dis 1997; 175:1263-7.
5. 5. Yazdanbakhsh M. Common features of T cell reactivity in persistent helminth infections: lymphatic filariasis and schistosomiasis. Immunol Lett 1999; 65:109-15.
6. 6. Ottesen EA, Hiatt RA, Cheever AW, Sotomayor ZR, Neva FA. The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man. Clin Exp Immunol 1978; 33:37-47.
7. 7. Grogan JL, Kremsner PG, Deelder AM, Yazdanbakhsh M. Antigen-specific proliferation and interferon-γ and interleukin-5 production are down-regulated during Schistosoma haematobium infection. J Infect Dis 1998; 177:1433-7.
8. + cells after chemotherapy in human Schistosoma haematobium infection. Eur J Immunol 1996; 26: 1365-70.
9. 9. Roberts M, Butterworth AE, Kimani G, et al. Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection. Infect Immun 1993; 61:4984-93.
10. 10. Sher A, Hieny S, James SL, Asofsky R. Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement. J Immunol 1982; 128:1880-4.
11. + T cells in immunity to Schitosoma mansoni induced by 20 krad-irradiated and RO 11-3128-terminated infections. Immunology 1989; 67:466-72.
12. 12. Burstein HJ, Sheam CM, Abbas AK. Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells. J Immunol 1992; 148:3687-91.
13. 13. De Wit D, Van Mechelen M, Ryelandt M, et al. The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes. J Exp Med 1992; 175: 9-14.
14. 14. Sloan-Lancaster J, Evavold B, Allen P. Th2 cell clonal anergy as a consequence of partial activation. J Exp Med 1994; 180:1195-205.
15. 15. Fasler S, Aversa G, Terr A, Thestrup-Pedersen K, de Vries J, Yssel H. Peptide-induced anergy in allergen-specific human Th2 cells results in lack of cytokine production and B cell help for IgE synthesis: reversal by IL-2, not by IL-4 or IL-13. J Immunol 1995; 155:4199-206.
16. 16. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9:271-96.
17. 17. Lanzavecchia A. Mechanisms of antigen uptake for presentation. Curr Opin Immunol 1996; 8:348-54.
18. 18. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179:1109-18.
19. 19. Grogan JL, Kremsner PG, Van Dam GJ, et al. Antischistosome IgG4 and IgE responses are affected differentially by chemotherapy in children versus adults. J Infect Dis 1996; 173:1242-7.
20. + T cells to secrete IL-4. Int Immunol 1998; 10:1017-26.
21. 21. Croft M, Bradley LM, Swain SL. Naive versus memory CD4 T cell response to antigen: memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol 1994; 152:2675-85.
22. 22. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-52.
23. 23. King CL, Medhat A, Malhotra I, et al. Cytokine control of parasite-specifc anergy in human urinary schistosomiasis: IL-10 modulates lymphocyte reactivity. J Immunol 1996; 156:4715-21.
24. 24. Parra JC, Lima MS, Gazzinelli G, Colley DG. Immune responses during human Schistosomiasis mansoni. XV. Anti-idiotypic T cells can recognize and respond to anti-SEA idiotypes directly. J Immunol 1988; 140:2401-5.
25. 25. Tsitoura DC, Holter W, Cerwenka A, Gelder CM, Lamb JR. Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands. J Immunol 1996; 156:2801-8.
26. 26. Faith A, Akdis CA, Akdis M, Joss A, Wymann D, Blaser K. An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling. J Immunol 1999; 162:1836-42.
27. + T cells from allergic individuals. J Exp Med 1993; 178:2123-30.
28. 28. Akdis CA, Akdis M, Blesken T, et al. Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 1996; 98:1676-83.
29. 29. O'Brien RM, Byron KA, Varigos GA, Thomas WR. House dust mite immunotherapy results in a decrease in Der p 2 specific IFN-γ and IL-4 expression by circulating T lymphocytes. Clin Exp Allergy 1997; 27:46-51.
30. 30. Bellinghausen I, Metz G, Enk AH, Christmann S, Knop J, Saloga J. Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects. Eur J Immunol 1997; 27:1131-9.
31. 31. Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283:1183-6.
32. 2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997; 159:28-35.
33. 33. Kalinski P, Hilkens CMU, Wierenga EA, Kapsenberg ML. T cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 1999; 20:561-7.
34. 34. Pelley RP, Ruffier JJ, Warren KS. Suppressive effect of a chronic helminth infection, schistosomiasis mansoni, on the in vitro responses of spleen and lymph node cells to the T cell mitogens phytohemagglutinin and concanavalin A. Infect Immun 1976; 13:1176-83.
35. 35. Yap G, Cheever A, Caspar P, Jankovic D, Sher A. Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell and gamma interferon deficient mice chronically infected with Schistosoma mansoni. Infect Immun 1997; 65:2583-6.
36. 36. Urban BC, Ferguson DJ, Pain A, et al. Plasmodium falciparion infected erythrocytes modulate the maturation of dendritic cells. Nature 1999; 400: 73-7.
37. 37. Chougnet C, Cohen SS, Kawamura T, et al. Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy. J Immunol 1999; 163:1666-73.