The tumor promoter TPA enhances benzo[a]pyrene and benzo[a]pyrene diolepoxide mutagenesis in Big Blue® mouse skin

Environmental and Molecular Mutagenesis

Volumn 35, Issue 4, 2000, Pages 319-327

  Miller, Marian L ^a   Vasunia, Kersi ^b   Talaska, Glenn ^a   Andringa, Anastasia ^a   De Boer, Johan ^c   Dixon, Kathleen ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Benzo a pyrene diol epoxide; Cell proliferation; DNA adducts; Lacl; Mutant frequency; Mutation fixation

Indexed keywords

BENZO[A]PYRENE; DIHYDROXYBENZO[A]PYRENE OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA ADDUCT; DNA DAMAGE; DNA SEQUENCE; DOSE RESPONSE; FEMALE; MITOSIS INDEX; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; SKIN CARCINOGENESIS; TRANSGENE;

ANIMALS; BASE SEQUENCE; BENZO(A)PYRENE; BENZOPYRENES; CARCINOGENS; DNA DAMAGE; DNA PRIMERS; FEMALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENS; SKIN; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 0033931272     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2280(2000)35:4<319::AID-EM6>3.0.CO;2-H     Document Type: Article

References (34)

1. Albert RE, Miller ML, Cody T, Shukla R, Baxter CS. 1991a. Benzo(a)pyrene-induced skin damage and tumor promotion in the mouse. Carcinogenesis 12:1273-1280.
2. Albert RE, Miller ML, Cody TE, Barkley W, Shukla R. 1991b. Cell kinetics and benzo(a)pyrene-DNA adducts in mouse skin tumorigenesis. Prog Clin Biol Res 369:115-122.
3. Albert RE, Miller ML, Talaska G, Underwood P, Cody TE, Andringa A. 1996. Epidermal cytokinetics, DNA adducts, and dermal inflammation in the mouse skin in response to repeated benzo(a)pyrene exposures. Toxicol Appl Pharm 136:67-74.
4. Chen T, Aidoo A, Manjanatha MG, Mittelstaedt RA, Shelton SD, Lyn-Cook LE, Casciano DA, Heflich RH. 1998. Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats. Mutat Res 403(1/2): 199-214.
5. de Boer JG, Glickman BW. 1998b. The lacI gene as a target for mutation in transgenic rodents and Escherichia coli. Genetics 148:1441-1451.
6. de Boer JG, Erfle H, Holcroft J, Walsh D, Dycaico M, Provost S, Short J, Glickman BW. 1996. Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats. Mutat Res 352(1/2):73-78.
7. de Boer JG, Erfle H, Walsh D, Holcroft J, Provost JS, Rogers B, Tindall KR, Glickman BW. 1997. Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ Mol Mutagen 30:273-286.
8. de Boer JG, Provost S, Gorelick N, Tindall K, Glickman BW. 1998a. Spontaneous mutation in lacI transgenic mice: a comparison of tissues. Mutagenesis 13:109-114.
9. Erfle HL, Walsh DF, Holcroft J, Hague N, De Boer JG, Glickman BW. 1996. An efficient laboratory protocol for the sequencing of large numbers of lacI mutants recovered from Big Blue transgenic animals. Environ Mol Mutagen 28:393-396.
10. Gorelick NJ, Andrews JL, Gu M, Glickman BW. 1995. Mutational spectra in the lacI gene in skin from 7,12-dimethylbenz(a)anthracene-treated and untreated transgenic mice. Mol Carcinog 14:53-62.
11. 32P-postlabelling analysis of non-radioactive aromatic carcinogen-DNA adducts. Carcinogenesis 3:1081-1092.
12. Hauser J, Seidman MM, Sidur K, Dixon K. 1985. Sequence specificity of point mutations induced during passage of a UV-irradiated shuttle vector plasmid in monkey cells. Mol Cell Biol 6:277-285.
13. IARC (International Agency for Research on Cancer). 1983. IARC Monogr Eval Carcinog Risks Hum 32:211-224.
14. Kohler SW, Provost GS, Fieck A, Kretz PL, Bullock WO, Sorge JA, Putman DL, Short JM. 1991a. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc Natl Acad Sci USA 88:7958-7962.
15. Kohler SW, Provost GS, Fieck A, Kretz PL, Bullock WO, Putman DL, Sorge JA, Short JM. 1991b. Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ Mol Mutagen 18:316-321.
16. Lee AT, DeSimone C, Cerami A, Bucala R. 1994. Comparative analysis of DNA mutations in lacI transgenic mice with age. FASEB J 8:545-550.
17. Manjanatha MG, Shelton SD, Aidoo A, Lyn-Cook LE, Casciano DA. 1998. Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue rats treated with 7,12-dimethylbenz(a)anthracene. Mutat Res 401:165-178.
18. Miller ML, Andringa A, Albert RE, Cody T. 1996a. Colcemid alters S phase and other parameters in skin during chronic exposure to benzo(a)pyrene. Microsc Res Tech 35:307-313.
19. Miller ML, Andringa A, Cody T, Dixon K, Albert RE. 1996b. Cell proliferation and nuclear abnormalities are increased and apoptosis is decreased in the epidermis of the p53 null mouse after topical application of benzo(a)pyrene. Cell Prolif 29:561-576.
20. Mittelstaedt RA, Manjanatha MG, Shelton SD, Lyn-Cook L, Chen JB, Aidoo A, Casciano DA, Heflich RH. 1998. Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats. Environ Mol Mutagen 31(2): 149-156.
21. Mullin AH, Nataraj D, Ren JJ, Mullin DA. 1998. Inhaled benzene increases the frequency and length of lacI deletion mutations in lung tissues of mice. Carcinogenesis 19:1723-1733.
22. Nesnow S. 1989. Mouse skin tumors and human lung cancer: relationships with complex mixtures. U.S. EPA Report 600D89-101. p 1-24.
23. Okonogi H, Stuart GR, Okochi E, Ushijima T, Sugimura T, Glickman BW, Nagao M. 1997a. Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo|4,5-b|pyridine in the lacI transgene. Mutat Res 395(2/3):93-99.
24. Okonogi H, Ushijima T, Zhang XB, Meddle JA, Suzuki T, Sofuni T, Felton JS, Tucker JD, Sugimura T, Magao M. 1997b. Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents. Carcinogenesis 18:745-748.
25. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7:1543-1551.
26. Roilides E, Gielen JE, Tuteja N, Levine AS, Dixon KD. 1988. Mutational specificity of benzo(a)pyrene diolepoxide in monkey cells. Mutat Res 198:199-206.
27. Ross JA, Leavitt SA. 1998. Induction of mutations by 2-acetylaminofluorene in lacI transgenic B6C3F1 mouse liver. Mutagenesis 13(2): 173-179.
28. Shane RS, Lockhart A-MC, Winston GW, Tindall KR. 1999. Mutant frequency of lacI in transgenic mice following benzo[a]pyrene treatment and partial hepatectomy. Mutat Res 377:1-11.
29. Suskind RR. 1990. The environment and the skin. Med Clin North Am 74:307-324.
30. Talaska G, Al-Juburi AZSS, Kadluhar FF. 1991. Smoking-related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-deoxyguanosin-8-yl-aminobiphenyl as a major adduct. Proc Natl Acad Sci USA 88:5350-5354.
31. Talaska G, Roh J-H, Getek T. 1992. Postlabelling and mass spectrometric methods for analysis of bulky, polyaromatic carcinogen-DNA adducts in humans. J Chromatogr 580:293-323.
32. Talaska G, Jaeger M, Reilman R, Collins T, Warshawsky D. 1996. Chronic, topical exposure to benzo(a)pyrene induces relatively high steady state levels of DNA adducts in target tissues and alters kinetics of adduct loss. Proc Natl Acad Sci USA 93:7789-7793.
33. Wang X, Suzuki T, Itoh T, Honma M, Nishikawa A, Furukawa F, Takahashi M, Hayashi M, Kato T, Sofuni T. 1998. Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice. Mutagenesis 13:625-630.
34. Weinberg RA. 1989. Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res 49:3713-3721.