Mutant frequency of lacI in transgenic mice following benzo[a]pyrene treatment and partial hepatectomy

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 377, Issue 1, 1997, Pages 1-11

  Shane, Barbara S ^a   Lockhart, Ann Marie C ^b   Winston, Gary W ^a   Tindall, Kenneth R ^c  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b Research Triangle Institute   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Benzo a pyrene; In vivo mutagenesis; Partial hepatectomy; Transgenic mouse

Indexed keywords

BENZO[A]PYRENE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IN VIVO STUDY; MALE; MOUSE; MUTAGENICITY; MUTATION RATE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; BACTERIOPHAGE LAMBDA; BENZO(A)PYRENE; BLOTTING, WESTERN; CELL DIVISION; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; ENZYME INDUCTION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEPATECTOMY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSOMES, LIVER; MUTAGENICITY TESTS; MUTAGENS; MUTATION; PLAQUE ASSAY; REPRESSOR PROTEINS; RNA, MESSENGER;

ANIMALIA; ESCHERICHIA COLI; MUS MUSCULUS; ZEA MAYS;

EID: 0030914357     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00004-3     Document Type: Article

References (36)

1. Mirsalis J.C., Monforte J.A., Winegar R.A. Transgenic animal models for measuring mutations in vivo. Crit. Rev. Toxicol. 24:1994;255-280.
2. Gorelick N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25:1995;218-230.
3. Dycaico M.J., Provost G.S., Kretz P.L., Ransom S.L., Moores J.C., Short J.M. The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutation Res. 307:1994;461-478.
4. Mirsalis J.C., Provost G.S., Matthews C.D., Hamner R.T., Schindler J.E., O'Loughlin K.G., MacGregor J.T., Short J.M. Induction of hepatic mutations in lacI transgenic mice. Mutagenesis. 8:1993;265-271.
5. Tinwell H., Lefevre P.A., Ashby J. Mutation studies with dimethylnitrosamine in young and old lacI transgenic mice. Mutation Res. 307:1994;501-508.
6. ®) following subchronic exposure to 2-acetylaminofluorene. Mutation Res. 302:1993;91-96.
7. Hayward J.J., Shane B.S., Tindall K.R., Cunningham M.L. In vivo mutant frequency of lacI in liver DNA of transgenic mice following dietary exposure to the carcinogen-noncarcinogen pair 2,4- and 2,6-diaminotoluene. Carcinogenesis. 16:1995;2429-2433.
8. Piegorsch W.W., Margolin B.H., Shelby M.D., Johnson A., French J.E., Tennant R.W., Tindall K.T. Study design and sample sizes for a lacI transgenic mouse mutation assay. Environ. Mol. Mutagen. 25:1995;231-245.
9. ® mice treated with N-ethyl-N-nitrosourea. Environ. Mol. Mutagen. 25:(Suppl. 25):1995;47.
10. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Putman D.L., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. USA. 88:1991;7958-7962.
11. Provost G.S., Kretz P.L., Hamner R.T., Matthews C.D., Rogers B.J., Lundberg K.S., Dycaico M.J., Short J.M. Transgenic system for in vivo mutation analysis. Mutation Res. 288:1993;133-149.
12. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Putman D.L., Sorge J.A., Short J.M. Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ. Mol. Mutagen. 18:1991;316-321.
13. Stefanski S.A., Greenwell A., Merrick B.A., Brown T.T., Reynolds S.H. Proliferating cell nuclear antigen (PCNA) staining of Fisher 344/N rat spleens affected by large granular lymphocyte (LGL) leukemia. Toxicol. Pathol. 28:1995;1-6.
14. Steiner J.W., Perz Z.M., Taichman L.B. Cell population dynamics in the liver. A review of quantitative morphological techniques applied to the study of physiological and pathological growth. Exp. Mol. Pathol. 5:1966;146-181.
15. Bridges, B.A., E. Zeiger and D. MacGregor (1981) Summary report on the performance of bacterial mutation assays, in: F.J. deSerres and J. Ashby (Eds.), Evaluation of Short-term Tests for Carcinogens, Progress in Mutation Research, vol. 1, Elsevier, New York, pp. 49-67.
16. Wood A.W., Chang R.L., Levin W., Yagi H., Thakker D.R., Jerina D.M., Conney A.H. Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides. Biochem. Biophys. Res. Commun. 77:1977;1389-1396.
17. Mazur M., Glickman B.W. Sequence specificity of mutations induced by benzo[a] pyrene-7,8-diol-9,10-epoxide at an endogenous aprt gene in CHO cells. Somatic Cell Mol. Genetics. 14:1988;393-400.
18. Phillips D.H., Hewer A., Seidel A., Steinbrecker T., Schrode R., Oesch F., Glatt H. Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons. Chem. Biol. Interact. 80:1991;177-186.
19. Hicks, R.M. and J. Ashby (1988) Review of the rodent carcinogenicity data for the four test chemicals, in: J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate and G.C. Becking (Eds.), Evaluation of short-term tests for carcinogens, vol. 2, Cambridge University Press, pp. 351-365.
20. Wislocki P.G., Bagan E.S., Lu A.Y.H., Dooley K.L., Fu P.P., Han-Hsu H., Beland A.A., Kadlubar F.F. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis. 7:1986;1317-1322.
21. ® transgenic mouse assay system: Instruction manual, La Jolla California.
22. Piegorsch W.W., Lockhart A.C., Margolin B.H., Tindall K.T., Gorelick N.J., Short J.M., Carr G.J., Thompson E.D., Shelby M.D. Sources and variability in data from a lacI transgenic mouse mutation assay. Environ. Mol. Mutagen. 23:1994;17-31.
23. Cochran W.G. Some methods for strengthening the common chi square tests. Biometrics. 10:1954;417-445.
24. J. Neter, W. Wasserman, M.H. Kutner, Applied Linear Statistical Models, 2nd edition, Irwin, R.D. Inc., Homewood, IL (1985) pp. 663-716; 963-1012.
25. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurements with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
26. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
27. Laemmli V.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
28. Winston G.W., Kirchin M.A., Ronis M.J.J. Microsomal activation of benzo(a)pyrene by Alligator mississippiensis: mechanisms, mutagenicity and induction. Biochem. Soc. Transact. 19:1991;746-750.
29. Weinstein J.B., Jeffery A.M., Jennette K.W., Blobstein S.H., Harvey R.G., Harris C., Autrup H., Kasai H., Nakanishi K. Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science. 193:1976;592-595.
30. Shou M., Korzekwa K.R., Crespi C.L., Gonzalez F.J., Gelboin H.V. The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P-450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol. Mol. Carcinogen. 10:1994;159-168.
31. Yokoyama H.O., Wilson M.E., Tsuboi K.K., Stowell R.E. Regeneration of mouse liver after partial hepatectomy. Cancer Res. 18:1953;80-85.
32. Fabricant J.I. The kinetics of cellular proliferation in regenerating liver. J. Cell Biol. 36:1968;551-565.
33. Doolittle D.J., Muller G., Scribner H.E. A comparative study of hepatic DNA repair, DNA replication and hepatotoxicity in the CD-1 mouse following multiple administration of dimethylnitrosamine. Mutation Res. 188:1987;141-147.
34. Cunningham M.L., Foley J., Maronpot R.R., Matthews H.B. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen: carcinogen pair-2,6- and 2,4-diaminotoluene. Toxicol. Appl. Pharmacol. 107:1991;562-567.
35. Sisk S.C., Pluta L.J., Bond J.A., Recio L. Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene. Carcinogenesis. 15:1994;471-477.
36. ® transgenic mice, Environ Mol Mutagen (1997) in press.