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3 Lobato MN, Loeffler AM, Furst K, Cole B, Hopewell PC: Detection of Mycobacterium tuberculosis in gastric aspirates collected from children: hospitalisation is not necessary. Pediatrics 1998, 102:40-41. This reference and the next one are significant in that they may contribute to the diagnosis of childhood tuberculosis in the community in more cases than is at present possible.
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13 Mudido PM, Guwatudde D, Nakakeeto MK, Bukenya GB, Nsamba D, Johnson JL, et al.: The effect of bacille Calmette-Guérin vaccination at birth on tuberculin skin test reactivity in Ugandan children. Int J Tuberc Lung Dis 1999, 3:891-895.
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15 Coovadia HM, Jeena P, Wilkinson D: Childhood human immunodeficiency virus and tuberculosis co-infections: reconciling conflicting data. Int J Tuberc Lung Dis 1998, 2:844-851. An interesting discussion of the high incidence of human immunodeficiency virus (HIV) seropositivity among children with tuberculosis in many countries but, by contrast, the low incidence of tuberculosis in cohorts of HIV-infected children.
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22 Kimerling ME, Phillips P, Patterson P, Hall M, Robinson A, Dunlap NE: Low serum antimycobacterial drug levels in non-HIV-infected tuberculosis patients. Chest 1998, 113:1178-1183. The authors document low concentrations of isoniazid and rifampin in adults receiving directly observed therapy. Even non-HIV patients therapeutic drug monitoring may be advantageous.
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23 Peloquin CA, Nitta AT, Burman WJ, Brudney KF, Miranda-Massari JR, McGuiness ME, et al.: Low antituberculosis drug concentrations in patients with AIDS. Ann Pharmacother 1996, 30:91-92. In this study low two-hours serum concentrations were frequently detected in patients with AIDS especially for rifampin and ethambutol. Isoniazid absorption was greatly satisfactory. Similar problems may well be encountered in children with HIV-infection/AIDS.
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24 Peloquin CA, Namdar R, Singleton MD, Nix DE: Pharmacokinetics of rifampin under fasting conditions with food and with antacids. Chest 1999, 115:12-18. This study found rifampin serum concentrations significantly reduced following a high fat meal. Because rifampin is critical for sterilization of tuberculosis lesions care should be taken to give rifampin on an empty stomach if possible.
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