Substrate competition and insulin action in animal models

International Journal of Obesity

Volumn 24, Issue , 2000, Pages S22-S24

  Vettor, R ^a   Lombardi, A M ^a   Fabris, R ^a   Serra, R ^a   Pagano, C ^a   Macor, C ^a   Federspil, G ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Free fatty acids; GLUT4; Insulin resistance; Lactate; Substrate competition

Indexed keywords

FATTY ACID; GLUCOSE; HEPARIN; INTRALIPID; LACTIC ACID; MESSENGER RNA; PROTEIN;

ADIPOSE TISSUE; CONFERENCE PAPER; FATTY ACID BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERLACTATEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; LACTATE BLOOD LEVEL; OBESITY; PHOSPHORYLATION; PRIORITY JOURNAL;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; INSULIN; INSULIN RESISTANCE; LACTIC ACID; OBESITY;

ANIMALIA;

EID: 0033928410     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801271     Document Type: Article

References (20)

1. Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes 1996; 20: 291-302.
2. Jahoor F, Klein S, Wolfe R. Mechanism of regulation of glucose production by lipolysis in humans. Am J Physiol 1992; 262: E353-358.
3. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-789.
4. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46: 3-10.
5. Hawkins M, Barzilai N, Liu R, Hu M, Chen W, Rossetti L. Role of glucosamine pathway in fat induced insulin resistance. J Clin Invest 1997; 99: 2173-2182.
6. Maggs DG, Jacob R, Rife F, Lange R, Leone P, During MJ, Tamborlane WV, Sherwin RS. Interstitial fluid concentrations of glycerol, glucose and amino-acids in human quadricep muscle and adipose tissue: evidence for significant lipolysis in skeletal muscle. J Clin Invest 1995; 96: 370-377.
7. Kruszynska YT, McCormack JG, McIntyre N. Effects of non-esterified fatty acid availability on insulin stimulated glucose utilization and tissue pyruvate dehydrogenase activity in the rat. Diabetologia 1990; 33: 396-402.
8. Issekutz B Jr, Shaw WAS, Issekutz AC. Lactate metabolism in resting and exercising dogs. Am J Physiol 1976; 40: 312-319.
9. Di Girolamo M, Newby FD, Hill JO. Blood lactate levels in human obesity. Int J Obes 1989; 13: 394.
10. Lovejoy J, Newby FD, Gebhart SSP, Di Girolamo M. Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Metabolism 1992; 41: 22-27.
11. Consoli A, Nurjhan N, Reilly JJ, Bier DM, Gerich JE. Mechanism of increased gluconeogenesis in non insulindependent diabetes mellitus. J Clin Invest 1990; 86: 2038-2045.
12. Doar JWH, Cramp DG. The effect of obesity and maturity-onset diabetes mellitus on L(+) lactic acid metabolism. Clin Scil 1970; 39: 271-279.
13. Di Girolamo M, Newby FD, Lovejoy J. Lactate production in adipose tissue: a regulated function with extra adipose implications. FASEB J 1992; 6: 2405-2412.
14. Vettor R, Lombardi AM, Fabris R, Pagano C, Cusin I, Rohner-Jeanrenaud F, Federspil G, Jeanrenaud B. Lactate infusion in anesthetized rats decreases overall glucose utilization and produces insulin resistance in skeletal muscle. Metabolism 1997; 46: 1-8.
15. Roth D, Brooks G. Lactate trasport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesicles. Arch Biochem Biophys 1990; 279: 377-385.
16. Consoli A, Nurjahan N, Gerich JE, Mandarino LJ. Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia. Metabolism 1992; 41: 176-179.
17. Pearce FJ, Connett RJ. Effect of lactate and palmitate on substrate utilization of isolated rat soleus. Am J Physiol 1980; 238: C149-159.
18. Lombardi AM, Fabris R, Bassetto F, Serra R, Leturque A, Federspil G, Girard J, Vettor R. Hyperlactatemia reduces muscle glucose uptake and GLUT4 mRNA while increasing (E1α)PDH gene expression in rat. Am J Physiol 1999; 276: E922.
19. Federspil G, Zaccaria M, Pedrazzoli S, Zago E, DePalo C, Scandellari C. Effects of sodium DL-lactate on insulin secretion in anesthetized dogs. Diabetes 1980; 29: 33-36.
20. Pagano C, Rizzato M, Lombardi AM, Fabris R, Favaro A, Federspil G, Vettor R. Effect of lactate on hepatic insulin clearance in perfused rat liver. Am J Physiol 1996; 270: R682-687.