Cold stress, near drowning and accidental hypothermia: A review

Aviation Space and Environmental Medicine

Volumn 71, Issue 7, 2000, Pages 733-752

  Giesbrecht, Gordon G ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Afterdrop; Anoxia; Cardiopulmonary bypass; Cold shock response; Core temperature; Heat balance; Heat loss; Hypoxia; Mammalian dive reflex; Shivering; Shivering thermogenesis

Indexed keywords

ACCIDENTAL HYPOTHERMIA; BRAIN PROTECTION; CARDIOPULMONARY BYPASS; COLD STRESS; EXERCISE; HEAT LOSS; HUMAN; LAVAGE; NEAR DROWNING; NONHUMAN; RADIOFREQUENCY RADIATION; REFLEX; REVIEW; SHIVERING; THERMOGENESIS; THERMOREGULATION; WARMING; WATER IMMERSION;

ACCIDENTS; ADOLESCENT; ADULT; AGED; BODY TEMPERATURE REGULATION; CARDIOPULMONARY BYPASS; CHILD; COLD; FEMALE; HUMANS; HYPOTHERMIA; MALE; MIDDLE AGED; NEAR DROWNING; PATIENT SELECTION; REWARMING; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

MAMMALIA;

EID: 0033924347     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (221)

1. Alexander L. The treatment of shock from prolonged exposure to cold, especially in water. Washington, DC: Office of Publication Board, Department of Commerce. Combined Intelligence Objectives Subcommittee. Target 24. Rep. 250. 1946; 1-228.
2. Andersson J, Schagatay E. Effects of lung volume and involuntary breathing movements on the human diving response. Eur J Appl Physiol 1998; 77:19-24.
3. Antretter H, Dapunt OE, Bonatti J. Management of profound hypothermia. Br J Hosp Med 1995; 54:215-20.
4. Barr GL, Halvorsen LO, Donovan AJ. Correction of hypothermia by continuous pleural perfusion. Surgery 1988; 103:553-7.
5. Baumgartner FJ, Janusz MT, Jamieson WR, et al. Cardiopulmonary bypass for resuscitation of patients with accidental hypothermia and cardiac arrest. Can J Surg 1992; 35:184-7.
6. Behnke AR, Yaglou CP. Physiological responses of men to chilling in ice water and to slow and fast rewarming. J Appl Physiol 1951; 3:591-602.
7. Benzinger TH. Heat regulation: homeostasis of central temperature in man. Physiol Rev 1969; 49:671-759.
8. Bierens JJ, van der Velde EA, van Berkel M, van Zanten JJ. Submersion in The Netherlands. prognostic indicators and results of resuscitation. Ann Emerg Med 1990; 19:1390-5.
9. Bigelow WG, Callaghan JC, Hopps JA. General hypothermia for experimental intracardiac surgery. Ann Surg 1950; 132:531-9.
10. Bolgiano E, Sykes L, Barish RA, et al. Accidental hypothermia with cardiac arrest: recovery following rewarming by cardiopulmonary bypass. J Emerg Med 1992; 10:427-33.
11. Bolte RG, Black PG, Bowers RS, et al. The use of extracorporeal rewarming in a child submerged for 66 minutes. JAMA 1988; 260:377-9.
12. Brandson RD, Chatburn RL. Humidification of inspired gases during mechanical ventilation (editorial). Respir Care 1993; 38:461-8.
13. Bristow GK, Giesbrecht GG. Contribution of exercise and shivering to recovery from induced hypothermia (31.2°C) in one subject. Aviat Space Environ Med 1988; 59:549-52.
14. Bristow GK, Sessler DI, Giesbrecht GG. Leg temperature and heat content in humans during immersion hypothermia and rewarming. Aviat Space Environ Med 1994; 65:220-6.
15. Brunette DD, Biros M, Mlinek EJ, et al. Internal cardiac massage and mediastinal irrigation in hypothermic cardiac arrest. Am J Emerg Med 1992; 10:32-4.
16. Brunette DD, Sterner S, Robinson EP, Ruiz E. Comparison of gastric lavage and thoracic cavity lavage in the treatment of severe hypothermia in dogs. Ann Emerg Med 1987; 16:1222-7.
17. Burton AC. Man in a cold environment. London: Edward Arnold Ltd., 1955.
18. Busto R, Dietrich WD, Globus MY-T, et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987; 7:729-38.
19. Busto R, Globus MY, Dietrich WD, et al. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rate brain. Stroke 1989; 20:904-10.
20. Cahill CJ, Balmi PJ, Tipton MJ. An evaluation of hand immersion for rewarming individuals cooled by immersion in cold water. Aviat Space Environ Med 1995; 66:418-23.
21. Carr MEJ, Wolfert AI. Rewarming by hemodialysis for hypothermia: failure of heparin to prevent DIC. J Emerg Med 1988; 6:277-80.
22. Castellani JW, Young AJ, Sawka MN, et al. Amnesia during cold water immersion: a case report. Wilderness Environ Med 1998; 9:153-5.
23. Chochinov AH, Baydock BMS, Bristow GK, Giesbrecht GG. Recovery of a 62-year-old man from prolonged cold water submersion. Ann Emerg Med 1998; 31:127-31.
24. Cohen DJ, Cline JR, Lepinski SM, et al. Resuscitation of the hypothermic patient. Am J Emerg Med 1988; 6:475-8.
25. Cohen JA, Blackshear RH, Gravenstein N, Woeste J. Increased pulmonary artery perforating potential of pulmonary artery catheters during hypothermia. J Cardiothorac Vasc Anesth 1991; 5:234-6.
26. Coles DR, Patterson CG. The capacity and distensibility of the blood vessels of the human hand. J Physiol (Lond) 1957; 135: 168-70.
27. Collins KJ, Easton JC, Exton-Smith AN. Body temperature afterdrop: a physical or physiological phenomenon? J Phys 1982; 328:72P-73P.
28. Collis ML, Steinman AM, Chaney RD. Accidental hypothermia: an experimental study of practical rewarming methods. Aviat Space Environ Med 1977; 48:625-32.
29. Conn AW, Miyasaka K, Katayama M, et al. A canine study of cold water drowning in fresh versus salt water. Crit Care Med 1995; 23:2029-37.
30. Cooper KE, Ferres HM, Kenyon JR, Wendt F. A comparison of oesophageal, rectal and para-aortic temperatures during hypothermia in man. Br J Surg 1957; 44:616-9.
31. Cooper KE, Martin S, Riben P. Respiratory and other responses in subjects immersed in cold water. J Appl Physiol 1976; 40: 903-10.
32. Covino BG. Pharmacology of local anaesthetic agents. Br J Anaesth 1986; 58:701-16.
33. Currie AE. How cold can you get? A case of severe neonatal hypothermia J R Soc Med 1994; 87:293-4.
34. Currie J. Medical reports on the effects of water, cold and warm, as a remedy in fever and other diseases, whether applied to the surface of the body, or used internally; including an inquiry into the circumstances that render cold drink, or the cold bath, dangerous in health to which are added observations on the nature of fever, and on the effects of opium, alcohol, and inanition, 2nd ed. Edinburgh: J. M'Creery, 1798; Appendix 21-44.
35. Daanen HAM, Van De Linde FJG. Comparison of four noninvasive rewarming methods for mild hypothermia. Aviat Space Environ Med 1992; 63:1070-6.
36. Danzl DF, Pozos RS, Hamlet MP. Accidental hypothermia. In: Auerbach PS, ed. Wilderness medicine: management of wilderness and environmental emergencies. St Louis, MO: Mosby. 1995; 51-103.
37. Davies DM, Millar EJ, Miller IA. Accidental hypothermia treated by extracorporeal blood warming. Lancet 1967; i:1036-7.
38. DelRossi AJ, Cernaianu AC, Vertrees RA, et al. Heparinless extracorporeal bypass for treatment of hypothermia. J Trauma 1990; 30:79-82.
39. Dietrich WD, Busto R, Halley M, Valdes I. The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia. J Neuropathol Exp Neurol 1990; 49:486-97.
40. Dixon RG, Dougherty JM, White LJ, et al. Transcutaneous pacing in a hypothermic dog model. Ann Emerg Med 1997; 29:602-6.
41. Dobson JAR, Burgess JJ. Resuscitation of severe hypothermia by extracorporeal rewarming in a child. J Trauma 1996; 40:483-5.
42. Drenck NE, von Staffeldt H. Repeated deep accidental hypothermia. A comparison of active or passive treatment in one patient. Anaesthesia 1986; 41:731-3.
43. Ducharme MB, Frim J, Bourdon L, Giesbrecht GG. Evaluation of infrared tympanic thermometers during normothermia and hypothermia in humans. In: Blatteis CM, ed. Thermoregulation: Tenth International Symposium on the Pharmacology of Thermoregulation. New York: New York Academy of Sciences, 1997; 813: 225-9.
44. Ducharme MB, Giesbrecht GG, Frim J, et al. Forced-air rewarming in -20°C simulated field conditions. In: Blatteis CM, ed. Thermoregulation: Tenth International Symposium on the Pharmacology of Thermoregulation. New York: New York Academy of Sciences, 1997; 813: 676-81.
45. co = 33.9 °C) hypothermia. In: Shapiro Y, Moran DS, Epstein Y, ed. Environmental ergonomics: recent progress and new frontiers. London: Freund Publishing Co., 1996; 147-50.
46. Ducharme MB, Tikuisis P. Role of blood as heat source or sink in human limbs during local cooling and heating. J Appl Physiol 1994; 76:2084-94.
47. Ereth MH, Lennon RL, Sessler DI. Limited heat transfer between thermal compartments during rewarming in vasoconstricted patients. Aviat Space Environ Med 1992; 63:1065-9.
48. Eyolfson D, Xu X, Weseen G, et al. Measurement and prediction of maximal shivering capacity in humans. In: Hodgdon JA, Heaney JH, Buono MJ, eds. Environmental Ergonomics VIII. International series on enviromental ergonomics, Vol. 1. San Diego: NHRC, 2000;315-7.
49. Fainer DC, Martin CG, Ivy AC. Resuscitation of dogs from fresh water drowning. J Appl Physiol 1951; 3:417-26.
50. Ferretti G. Cold, and muscle performance. Int J Sports Med 1992; 13:S185-7.
51. Fildes J, Sheaff C, Barrett J. Very hot intravenous fluid in the treatment of hypothermia. J Trauma 1993; 35:683-6.
52. Forgey WW, ed. Wilderness Medical Society practice guidelines for wilderness emergency care. Merrillville, IN: ICS Books, Inc., 1995.
53. Fox JB, Thomas F, Clemmer TP, Grossman M. A retrospective analysis of air-evacuated hypothermia patients. Aviat Space Environ Med 1988; 59:1070-5.
54. Franks CM, Golden FS, Hampton IFG, Tipton MJ. The effect of blood alcohol on the initial responses to cold water immersion in humans. Eur J Appl Physiol 1997; 75:279-81.
55. Garlow L, Kokiko J, Pino-Marina R, Church F. Hypothermia in a 62-year-old man: use of the continuous arteriovenous rewarming technique. J Emerg Nurs 1996; 22:477-80.
56. Gautam PC, Ghosh S, Mandai AR, Vargas E. Hypothermia in the elderly: management in a purpose-built chamber. Gerontology 1988; 34:145-50.
57. Gentilello LM. Continuous arteriovenous rewarming: rapid reversal of hypothermia in critically ill patients. J Trauma 1992; 32:316-27.
58. Gentilello LM, Cortes V, Moujaes S, et al. Continuous arterio-venous rewarming: experimental results and themodynamic model simulation of treatment for hypothermia. J Trauma 1990; 30:1436-49.
59. Gentilello LM, Rifley WJ. Continuous arteriovenous rewarming: report of a new technique for treating hypothermia. J Trauma 1991; 31:1151-4.
60. Giesbrecht GG, Bristow GK. Decrement in manual arm performance during whole body cooling. Aviat Space Environ Med 1992; 63:1077-81.
61. Giesbrecht GG, Bristow GK. A second postcooling afterdrop: more evidence for a convective mechanism. J Appl Physiol 1992; 73:1253-8.
62. Giesbrecht GG, Bristow GK. Influence of body composition on rewarming from immersion hypothermia. Aviat Space Enriron Med 1995; 66:1144-50.
63. Giesbrecht GG, Bristow GK. Recent advances in hypothermia research. In: Blatteis CM, ed. Thermoregulation: Tenth International Symposium on the Pharmacology of Thermoregulation. New York: New York Academy of Sciences, 1997; 813: 663-675.
64. Giesbrecht GG, Bristow GK, Uin A, et al. Effectiveness of three field treatments for induced mild (33.0°C) hypothermia. J Appl Physiol 1987; 63:2375-9.
65. Giesbrecht GG, Goheen MSL, Johnston CE, et al. Inhibition of shivering increases core temperature afterdrop and attenuates rewarming in hypothermic humans. J Appl Physiol 1997; 83: 1630-4.
66. Giesbrecht GG, Johnston CE, Bristow GK. The convective afterdrop component during hypothermic exercise decreases with delayed exercise onset. Aviat Space Environ Med 1998; 69:17-22.
67. Giesbrecht GG, Pachu P, Xu X. Design and evaluation of a portable rigid forced-air warming cover for prehospital transport of cold patients. Aviat Space Environ Med 1998; 69:1200-3.
68. Giesbrecht GG, Schroeder M, Bristow GK. Treatment of mild immersion hypothermia by forced-air warming. Aviat Space Environ Med 1994; 65:803-8.
69. Giesbrecht GG, Sessler DI, Mekjavic IB, et al. Treatment of mild immersion hypothermia by direct body-to-body contact. J Appl Physiol 1994; 76:2373-9.
70. Giesbrecht GG, Wu MP, White MD, et al. Isolated effects of peripheral arm and central body cooling on arm performance. Aviat Space Environ Med 1995; 66:968-75.
71. Ginsberg MD, Globus MY, Dietrich WD, Busto R. Temperature modulation of ischemic brain injury-a synthesis of recent advances. Prog Brain Res 1993; 96:13-22.
72. Glickman-Weiss EL, Goss FL, Robertson RJ, et al. Physiological and thermal responses of males with varying body compositions during immersion in moderately cold water. Aviat Space Environ Med 1991; 62:1063-7.
73. Glickman-Weiss EL, Hearon CM, Prisby R, Caine N. The perceptual and physiological responses of high and low fat women exposed to 5°C air for 120 minutes. Wilderness Environ Med 1998; 9:204-10.
74. Glickman-Weiss EL, Nelson AG, Hearon CM, et al. Thermal and metabolic responses of women with high fat versus low fat body composition during exposure to 5 and 27°C for 120 min. Aviat Space Environ Med 1999; 70:284-8.
75. Globus MY, Busto R, Lin B, et al. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 1995; 65:1250-6.
76. Goheen MSL, Ducharme MB, Kenny GP, et al. Efficacy of forced-air and inhalation rewarming by using a human model for severe hypothermia. J Appl Physiol 1997; 83:1635-40.
77. Golden F. Mechanisms of body cooling in submersed victims. Resuscitation 1997; 35:107-9.
78. Golden FSC. Death after rescue from immersion in cold water. J Roy Naval Med Service 1973; 59:5-7.
79. Golden FSC. Rewarming. In: Pozos RS, Wittmers LE, ed. The nature and treatment of hypothermia. Minneapolis, MN: University of Minnesota Press, 1983; 194-208.
80. Golden FSC, Hervey GR, Tipton MJ. Circum-rescue collapse: collapse, sometimes fatal, associated with rescue of immersion victims. J Roy Nav Med Serv 1991; 77:139-49.
81. Golden FSC, Tipton MJ, Scott RC. Immersion, near-drowning and drowning. Br J Anaesth 1997; 79:1-12.
82. Golden GSC, Hervey GR. The mechanism of the after-drop following immersion hypothermia in pigs. J Physiol 1977; 272: 26-7.
83. Gooden BA. Why some people do not drown. Hypothermia versus the diving response. Med J Aust 1992; 157:629-32.
84. Grahn D, Brock-Utne JG, Watenpaugh DE, Heller HC. Recovery from hypothermia can be accelerated by mechanically distending blood vessels in the hand. J Appl Physiol 1998; 85:1643-8.
85. Greenfield ADM, Patterson GC. On, the capacity and distensibility of the blood vessels of the human forearm. J Physiol (Lond) 1956; 131:290-306.
86. Gregory JS, Bergstein JM, Aprahamian C, et al. Comparison of three methods of rewarming from hypothermia: advantages of extracorporeal blood warming. J Trauma 1991; 31:1247-52.
87. Hall KN. Closed thoracic cavity lavage in the treatment of severe hypothermia in human beings. Ann Emerg Med 1990; 19: 204-6.
88. Hamilton RS, Paton BC. The diagnosis and treatment of hypothermia by mountain rescue teams: a survey. Wilderness Environ Med 1996; 7:28-37.
89. Harnett RM, O' Brien EM, Sias FR, Pruitt JR. Initial treatment of profound accidental hypothermia. Aviat Space Environ Med 1980; 51:680-87.
90. Harnett RM, Pruitt JR, Sias FR. A review of the literature concerning resuscitation from hypothermia: Part I -the problem and general approaches. Aviat Space Environ Med 1983; 54: 425-34.
91. Harnett RM, Pruitt JR, Sias FR. A review of the literature concerning resuscitation from hypothermia: Part II-selected rewarming protocols. Aviat Space Environ Med 1983; 54:487-95.
92. Hayward JS, Eckerson JD, Collis ML. Effect of behavioral variables on cooling rate of man in cold water. J Appl Physiol 1975; 38:1073-7.
93. Hayward JS, Eckerson JD, Collis ML. Thermal balance and survival time prediction of man in cold water. Can J Physiol Pharmacol 1975; 53:21-32.
94. Hayward JS, Eckerson JD, Kemna D. Thermal and cardiovascular changes during three methods of resuscitation from mild hypothermia. Resuscitation 1984; 11:21-33.
95. Hayward JS, Matthews BR, Overweel CH, Radford DD. Temperature effect on the human dive response in relation to cold water near-drowning. J Appl Physiol: Respirat Environ Exercise Physiol 1984; 56:202-6.
96. Hayward JS, Steinman AM. Accidental hypothermia: an experimental study of inhalation rewarming. Aviat Space Environ Med 1975; 46:1236-40.
97. Hegnauer AH. Lethal hypothermic temperatures for dog and man. Ann NY Acad Sci 1959; 80:315-9.
98. Heise D, Rathgeber J, Burchardi H. Severe, accidental hypothermia: active rewarming with a simple extracorporeal venovenous warming-circuit (German). Anaesthesist 1996; 45: 1093-6.
99. Hernandez E, Praga M, Alcazar JM, et al. Hemodialysis for treatment of accidental hypothermia. Nephron 1993; 63:214-6.
100. Hesslink RL, Pepper S, Olsen RG, et.al. Radio frequency (13.45 MHz) energy enhances recovery from mild hypothermia. J Appl Physiol 1989; 67:1208-12.
101. Holmer I. Prediction of responses to cold. Arct Med Res 1995; 54:48-54.
102. Hoskin RW, Melinyshyn MJ, Romet TT, Goode RC. Bath rewarming from immersion hypothermia. J Appl Physiol 1986; 61:1518-22.
103. Hultzer M, Xu X, Marrao M, et al. Efficacy of torso rewarming using a human model for severe hypothermia (abstract). Proceedings of the World Congress on Wilderness Medicine. Whistler, BC, Canada: Wilderness Medical Society, 1999; 80.
104. Iampietro PF, Vaughan JA, Goldman RF, et al. Heat production from shivering. J Appl Physiol 1960; 15:632-4.
105. Jacobs I. Fuelling shivering in humans during cold water immersion. Proceedings of the AGARD Conference Proceedings 540. The Support of Air Operations Under Extreme Hot and Cold Weather Conditions. North Atlantic Treaty Orgainzation 1993; 6:1-6.3.
106. Jacobs I, Martineau L, Vallerand AL. Thermoregulatory thermogenesis in humans during cold stress. In: Holloszy JO, ed. Exercise and sport science reviews. Baltimore: Williams & Wilkins, 1994; 221-50.
107. Kanaar AC, Hecht MW. Marathon swim training in a 74-yr-old man: personal experiences. Med Sci Sports Exerc 1992; 24: 490-4.
108. Kangas E, Niemela H, Kojo N. Treatment of hypothermic circulatory arrest with thoracotomy and pleural lavage. Ann Chir Gynaecol 1994; 83:258-60.
109. Katsura K, Minamisawa H, Ekholm A, et al. Changes of labile metabolites during anoxia in moderately hypo- and hyperthermic rats: correlation to membrane fluxes of K+. Brain Res 1992; 590:6-12.
110. Kaufman JW, Hamilton R, Dejneka KY, Askew GK. Comparative effectiveness of hypothermia rewarming techniques: radio frequency energy vs. warm water. Resuscitation 1995; 29:203-14.
111. Kaufman WC. The development and rectification of hiker's hypothermia. In: Pozos RS, Wittmers LE, ed. The nature and treatment of hypothermia. Minneapolis, MN: University of Minnesota Press, 1983; 46-57.
112. Keatinge WR. Death after shipwreck. Br J Med 1965; 25:1537-41.
113. Keatinge WR. Survival in cold water. Oxford: Blackwell Scientific Publishing, 1969.
114. Keatinge WR, McIlroy MB, Goldfien A. Cardiovascular responses to ice-cold showers. J Appl Physiol 1964; 19:1145-50.
115. Kelly KJ, Glaeser P, Rice T, Wendelberger KJ. Profound accidental hypothermia and freeze injury of the extremities in a child. Crit Care Med 1990; 18:679-80.
116. King RB, Webster IW. A case of recovery from drowning and prolonged anoxia. Med J Aust 1964; 1:919-20.
117. Koller R, Schnider TW, Neidhart P. Deep accidental hypothermia and cardiac arrest-rewarming with forced air. Acta Anaesthesiol Scand 1997; 41:1359-64.
118. Kornberger E, Mair PJ. Important aspects in the treatment of severe accidental hypothermia. Neurosurg Anesthesiol 1996; 8:72-83.
119. Kristensen G, Drenck NE, Jordening H. Simple system for central rewarming of hypothermia patients (letter). Lancet 1986; 2:1467-8.
120. Kristensen G, Gravesen H, Benveniste D, Jordening H. An oesophageal thermal tube for rewarming in hypothermia. Acta Anaesthesiol Scand 1985; 29:846-8.
121. Kristensen G, Gravesen H, Jordening H. Internal rewarming in hypothermia using a specially constructed gastro-oesophageal tube. A non-invasive method. Acta Anaesthesiol Belg 1984; 35:175-7.
122. Kugelberg J, Schüller H, Berg B, Kallum B. Treatment of accidental hypothermia. Scand J Thor Cardiovasc Surg 1967; 1:142-6.
123. Kurz A, Kurz M, Hackl W, et al., Forced-air warming maintains intra-operative normothermia better than circulating-water in infants and children. Anesth Analg 1993; 77:89-95.
124. Lash RF, Burdette JA, Ozdil T. Accidental profound hypothermia and barbiturate intoxication. JAMA 1967; 201:269-70.
125. Lauri T. Cardiovascular responses to an acute volume load in deep hypothermia. Eur Heart J 1996; 17:606-11.
126. LeBlanc J. Subcutaneous fat and skin temperature. Can J Biochem Physiol 1954; 32:354-8.
127. Ledingham IM, Mone JG. Treatment of accidental hypothermia: a prospective clinical study. Br J Med 1980; 280:1102-5.
128. Letsou GV, Kopf GS, Elefteriades JA, et al. Is cardiopulmonary bypass effective for treatment of hypothermic arrest due to drowning or exposure? Arch Surg 1992; 127:525-8.
129. Levitt MA, Kane V, Henderson J, Dryjski M. A comparative rewarming trial of gastric versus peritoneal lavage in a hypothermic model. Am J Emerg Med 1990; 8:285-8.
130. Lexow K. Severe accidental hypothermia: survival after 6 hours 30 minutes of cardiopulmonary resuscitation. Arct Med Res 1991; 50:112-4.
131. Lin B, Busto R, Globus MY, et al. Brain temperature modulations during global ischemia fail to influence extracellular lactate levels in rats. Stroke 1995; 26:1634-8.
132. Livingstone SD, Nolan RW, Cattroll SW. Heat loss caused by immersing the hands in water. Aviat Space Environ Med 1989; 60:1166-71.
133. Livingstone SD, Nolan RW, Keefe AA. Heat loss caused by cooling the feet. Aviat Space Environ Med 1995; 66:232-7.
134. Lloyd EL. Hypothermia, and cold stress. London: Croom Helm, 1986; 400.
135. Lloyd EL, Conliffe NA, Orgel H, Walker PN. Accidental hypothermia: an apparatus for central re-warming as a first aid measure. Scot Med J 1972; 17:83-91.
136. Marcus P. Laboratory comparison of techniques for rewarming hypothermic casualties. Aviat Space Environ Med 1978; 49: 692-7.
137. Maresca L, Vasko JS. Treatment of hypothermia by extracorporeal circulation and internal rewarming. J Trauma 1987; 27:89-90.
138. Marion DW, Leonov Y, Ginsberg M., et al. Resuscitative hypothermia. Crit Care Med 1996; 24:S81-9.
139. McCance RA, Ungley CC, Crosfill JWL, Widdowson EM. The hazards to men in ships lost at sea, 1940-44. Medical Research Council Special Report Series. Report 291. London: Her Majestey's Stationery Office, 1956: 1-44.
140. McGuire JP, Giesbrecht GG. A comparison of three forced-air patient warming systems. Anesth Analg 1993; 76:S256.
141. Mekjavic IB, Eiken O. Inhalation rewarming from hypothermia: an evaluation in -20°C simulated field conditions. Aviat Space Environ Med 1995; 66:424-9.
142. Mekjavic IB, La Prairie A, Burke W, Lingborg B. Respiratory drive during sudden cold water immersion. Resp Physiol 1987; 70:121-30.
143. Mercer JB. Enhancing tolerance to cold exposure-how successful have we been? Arct Med Res 1995; 54:70-5.
144. Michenfelder JD, Milde JH. The relationship among canine brain temperature, metabolism, and function during hypothermia. Anesthesiology 1991; 75:130-6.
145. Michenfelder JD, Theye RA. Hypothermia. Effect on canine brain and whole-body metabolism. Anesthesiology 1968;1107-12.
146. Miles JM, Thompson GR. Treatment of severe accidental hypothermia using the Clinitron bed. Anaesthesia 1987; 42:415-8.
147. Miller JW, Danzl DF. Accidental hypothermia: a survivor of 12 episodes. J Emerg Med 1984; 1:407-10.
148. Mills WJJ. Accidental hypothermia: management approach. Alaska Med 1993; 35:54-6.
149. Minamisawa H, Nordstrom CH, Smith ML, Siesjo BK. The influence of mild body and brain hypothermia on ischemic brain damage. J Cereb Blood Flow Metab 1990; 10:365-74.
150. Morrison JB, Conn ML, Hayes PA. Influence of respiratory heat transfer on thermogenesis and heat storage after cold immersion. Clin Sci (Lond) 1982; 63:127-35.
151. Niazi SA, Lewis EJ. Profound hypothermia in the dog. Surg Gynecol Obstet 1956; 102:98-106.
152. Norberg WJ, Agnew RF, Brunsvold R, et al. Successful resuscitation of a cold water submersion victim with the use of cardiopulmonary bypass. Crit Care Med 1992; 20:1355-7.
153. Oksa J, Rintamaki H, Hassi J, Rissanen S. Gross efficiency of muscular work during step exercise at -15°C and 21°C. Acta Physiol Scand 1993; 147:235-40.
154. Olsen RG. Reduced temperature afterdrop in Rhesus monkeys with radio frequency rewarming. Aviat Space Environ Med 1988; 59:78-80.
155. Osborne L, Kamal El Din AS, Smith JE. Survival after prolonged cardiac arrest and accidental hypothermia. Br Med J Clin Res Ed. 1984; 289:881-2.
156. Otto RJ, Metzler MH. Rewarming from experimental hypothermia: comparison of heated aerosol inhalation, peritoneal lavage, and pleural lavage. Crit Care Med 1988; 16:869-75.
157. Parkinson D. Carotid cavernous fistula: direct repair with preservation of the carotid artery. J Neurosurg 1973; 38:99-106.
158. Paton BC. Accidental hypothermia. Pharmacol Ther 1983; 22: 331-77.
159. Patton JF, Doolittle WH. Core rewarming by peritoneal dialysis following induced hypothermia in the dog. J Appl Physiol 1972; 33:800-4.
160. Pozos RS, Hesslink RL, Reading J, et al. Rewarming methodologies in the field. Proceedings of the AGARD Conference Proceedings 540. The Support of Air Operations under Extreme Hot and Cold Weather Conditions. Victoria, BC, Canada: North Atlantic Treaty Organization 1993; 22:1-22.8.
161. Pugh LGCE. Accidental hypothermia in walkers, climbers, and campers: Report to the medical commission on accident prevention. Br J Med 1966; 1:123-9.
162. Pugh LGCE. Cold stress and muscular exercise, with special reference to accidental hypothermia. Br J Med 1967; 2:333-7.
163. Ramey CA, Ramey DN, Hayward JS. The dive response of children in relation to cold-water near-drowning. J Appl Physiol 1987; 63:665-8.
164. Rasmussen YH, Leikersfeldt G, Dranck NE. Forced-air surface warming versus oesophagael heat exchanger in the prevention of perioperative hypothermia. Acta Anaesthesiol Scand 1998; 42:348-52.
165. Rintamaki H, Hassi J, Oksa J, Makinen T. Rewarming of feet by lower and upper body exercise. Eur J Appl Physiol 1992; 65:427-32.
166. Rogers I. Which rewarming therapy in hypothermia? A review of the randomised trials. Emerg Med 1997; 9:213-20.
167. Romet TT. Mechanism of afterdrop after cold water immersion. J Appl Physiol 1988; 65:1535-8.
168. Romet TT, Hoskin RW. Temperature and metabolic responses to inhalation and bath rewarming protocols. Aviat Space Environ Med 1988; 59:630-4.
169. Sagawa S, Shiraki K, Yousef MK, Konda N. Water temperature and intensity of exercise in maintenance of thermal equilibrium. J Appl Physiol 1988; 65:2413-9.
170. Sano T, Drummond JC, Patel PM, et al. A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat. Anesthesiology 1992; 76:221-8.
171. Savard GK, Cooper KE, Veale WL, Malkinson TJ. Peripheral blood flow during rewarming from mild hypothermia in humans. J Appl Physiol 1985; 58:4-13.
172. Schagatay E. The human diving response: effects of temperature and training [Ph.D. Thesis]. University of Lund, Sweden, 1996.
173. Schagatay E, Holm B. Effects of water and ambient air temperatures on human diving bradycardia. Eur J Appl Physiol 1996; 73:1-6.
174. Sekar TS, MacDonnell KF, Namisirikul P, Herman RS. Survival after prolonged submersion in cold water without neurologic sequelae. Arch Intern Med 1980; 140:775-9.
175. Sessler DI. Mild perioperative hypothermia. N Engl J Med 1997; 336:1730-7.
176. Sessler DI, Moayeri A. Skin-surface warming: heat flux and central temperature. Anesthesiology 1990; 73:218-24.
177. Sheaff CM, Fildes JJ, Keogh P, et al. Safety of 65°C intravenous fluid for the treatment of hypothermia. Am J Surg 1996; 172: 52-5.
178. Smith CE, Parand A, Pinchak AC, et al. Failure of negative pressure rewarming (Thermostat™) to accelerate recovery from mild hypothermia in postsurgical patients (abstract). Anesth Analog 1999;89:1541-5.
179. Soreide E, Grahn DA, Brock-Utne JG, Rosen L. A non-invasive means to effectively restore normothermia in cold stressed individuals: a preliminary report. J Emerg Med 1999; 17:725-30.
180. Splittgerber FH, Talbert JG, Sweezer WP, Wilson RF. Partial cardiopulmonary bypass for core rewarming in profound accidental hypothermia. Am Surg 1986; 52:407-12.
181. Steele MT, Nelson MJ, Sessler DI, et al. Forced air speeds rewarming in accidental hypothermia. Ann Emerg Med 1996; 27:479-84.
182. Sterba JA. Efficacy and safety of prehospital rewarming techniques to treat accidental hypothermia. Ann Emerg Med 1991; 20:896-901.
183. Stoneham MD, Squires SJ. Prolonged resuscitation in acute deep hypothermia. Anaesthesia 1992; 47:784-8.
184. Suominen PK, Korpela RE, Silfvast TGO, Olkkola KT. Does water temperature affect outcome of nearly drowned children. Resuscitation 1997; 35:111-5.
185. Thompson DA, Anderson N. Successful resuscitation of a severely hypothermic neonate. Ann Emerg Med 1994; 23:1390-3.
186. Thompson RL, Hayward JS. Wet-cold exposure and hypothermia: thermal and metabolic responses to prolonged exercise in rain. J Appl Physiol 1996; 81:1128-37.
187. Tikuisis P. Prediction of survival time at sea based on observed body cooling rates. Aviat Space Environ Med 1997; 68:441-8.
188. Tipton MJ. The relationship between maximum breath hold time in air and the ventilatory responses to immersion in cold water. Eur J Appl Physiol 1992; 64:426-9.
189. Todd MM, Warner DS. A comfortable hypothesis reevaluated: cerebral metabolic depression and brain protection during ischemia. Anesthesiology 1992; 76:161-4.
190. Troelsen S, Rybro L, Knudsen F. Profound accidental hypothermia treated with peritoneal dialysis. Scand J Urol Nephrol 1986; 20:221-4.
191. Vallerand AL. Biochemical enhancement of cold tolerance. Proceedings of the AGARD Conference Proceedings 540. The Support of Air Operations under Extreme Hot and Cold Weather Conditions. Victoria, BC, Canada: North Atlantic Treaty Organization, 1993; 8:1-8.8.
192. Vallerand AL, Jacobs I. Rates of energy substrates utilization during human cold exposure. J Appl Physiol 1989; 58:873-8.
193. Vallerand AL, Jacobs I, Kavanagh MF. Mechanism of enhanced cold tolerance by an ephedrine-caffeine mixture in humans. J Appl Physiol 1989; 67:438-44.
194. Vallerand AL, Tikuisis P, Ducharme MB, Jacobs I. Is energy substrate mobilization a limiting factor for cold thermogenesis? Eur J Appl Physiol 1993; 67:239-44.
195. Vanggaard L. Physiological reactions to wet-cold. Aviat Space Environ Med 1975; 46:33-6.
196. Vanggaard L. Ny Laegebog for sofarende (Authorized ship captain's guide). Copenhagen, Denmark: Tellus, 1987: 1-380.
197. Vanggaard L. Thermoregulation in the extreme cold environment. Proceedings of the AGARD Conference Proceedings 540. The Support of Air Operations under Extreme Hot and Cold Weather Conditions. Victoria, BC, Canada: North Atlantic Treaty Organization, 1993; 19:1-19.14.
198. Vanggaard L, Eyolfson D, Xu X, et al. Immersion of distal arms and legs in warm water (AVA rewarming) effectively rewarms hypothermic humans. Aviat Space Environ Med 1999; 70: 1081-8.
199. Vanggaard L, Gjerloff CC. A new simple technique of rewarming in hypothermia. Int Rev Army, Navy Air Force Med Serv 1979; 52:427-30.
200. Vella J, Farrell J, Leavey S, et al. The rapid reversal of profound hypothermia using peritoneal dialysis. Irish J Med Sci 1996; 165:113-4.
201. Vincent MJ, Tipton MJ. The effects of cold immersion and hand protection on grip strength. Aviat Space Environ Med 1988; 59:738-41.
202. von-Segesser LK, Garcia E, Turina M. Perfusion without systemic heparinization for rewarming in accidental hypothermia. Ann Thorac Surg 1991; 52:560-1.
203. Vretenar DF, Urschel JD, Parrott JC, Unruh HW. Cardiopulmonary bypass resuscitation for accidental hypothermia. Ann Thorac Surg 1994; 58:895-8.
204. Walpoth BH, Locher T, Leupi F, et al. Accidental deep hypothermia with cardiopulmonary arrest: extracorporeal blood rewarming in 11 patients. Eur J Cardiothorac Surg 1990; 4:390-3.
205. Walpoth BH, Walpoth-Aslan BN, Mattle HP, et al. Outcome of survivors of accidental deep hypothermia and circulatory arrest treated with extracorporeal blood warming. N Engl J Med 1997; 337:1500-5.
206. Waters DJ, Belz M, Lawse D, Ulstad D. Portable cardiopulmonary bypass: resuscitation from prolonged ice-water submersion and asystole. Ann Thorac Surg 1994; 57:1018-9.
207. Webb P. Afterdrop of body temperature during rewarming: an alternative explanation. J Appl Physiol 1986; 60:385-90.
208. Weinberg AD. The role of inhalation rewarming in the early management of hypothermia. Resuscitation 1998; 36:101-4.
209. Weller AS, Millard CE, Stroud MA, et al. Physiological responses to a cold, wet, and windy environment during prolonged intermittent walking. Am J Physiol 1997; 272 (Regulatory Integrative Comp: Physiol 41):R226-33.
210. Werner J, Webb P. A six-cylinder model of human thermoregulation for general use on personal computers. Ann Physiol Anthrop 1993; 12:123-34.
211. White JD, Butterfield AB, Greer KA, et al. Comparison of rewarming by radio wave regional hyperthermia and warm humidified inhalation. Aviat Space Environ Med 1984; 55: 1103-6.
212. White JD, Butterfield AB, Greer KA, et al. Controlled comparison of radio wave regional hyperthermia and peritoneal lavage rewarming after immersion hypothermia. J Trauma 1985; 25: 989-93.
213. White JD, Butterfield AB, Nucci RC, Johnson C. Rewarming in immersion hypothermia: radio-wave and inhalation therapy. Resuscitation 1986; 14:141-8.
214. White JD, Butterfield AB, Nucci RC, Johnson C. Rewarming in accidental hypothermia: radio wave versus inhalation therapy. Ann Emerg Med 1987; 16:50-4.
215. Wisborg T, Husby P, Engedal H. Anesthesiologist-manned helicopters and regionalized extracorporeal circulation facilities: a unique chance in deep hypothermia. Arct Med Res 1991; 50:108-11.
216. Wissler EH. Mathematical simulation of human thermal behavior using whole body models. In: Shitzer A, Eberhart RC, ed. Heat transfer in medicine and biology. New York: Plenum Press, 1985; 325-73.
217. Wittmers LEJ, Pozos RS, Fall G, Beck L. Cardiovascular responses to face immersion (the diving reflex) in human beings after alcohol comsumption. Ann Emerg Med 1987; 16:1031-6.
218. Xiao F, Safar P, Radovsky A. Mild protective and resuscitative hypothermia for asphyxial cardiac arrest in rats. Am J Emerg Med 1998; 16:17-25.
219. Xu X, Tikuisis P, Giesbrecht G. A mathematical model for human brain cooling during cold water near-drowning. J Appl Physiol 1999; 86:265-72.
220. Xu X, Werner J. A dynamic model of the human/clothing/ environment system. Appl Human Sci 1997; 16:61-75.
221. Young AJ, Castellani JW, O'Brien C, et al. Exertional fatigue, sleep loss, and negative energy balance invrease susceptibility to hypothermia. J Appl Physiol 1998; 85:1210-7.