Gastrointestinal function, divalent metal transporter-1 expression and intestinal iron absorption

Pflugers Archiv European Journal of Physiology

Volumn 440, Issue 3, 2000, Pages 496-502

  Oates, Phillip S ^a   Trinder, Deborah ^a   Morgan, Evan H ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Absorption; DCT1; F erric; Ferroportin; Immunohistochemistry; IREG1; MRNA; Nramp2; Regulation; Transfer; Uptake

Indexed keywords

CARRIER PROTEIN; DIVALENT CATION; FERRIC ION; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; INTESTINE CELL; IRON ABSORPTION; IRON DEFICIENCY; IRON INTAKE; MICROVILLUS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANEMIA, IRON-DEFICIENCY; ANIMALS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; DIET; DUODENUM; GASTRIC LAVAGE; GENE EXPRESSION; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; INTESTINAL ABSORPTION; IRON, DIETARY; IRON-BINDING PROTEINS; MALE; ORGAN SIZE; RATS; RATS, WISTAR; RNA, MESSENGER; STOMACH;

EID: 0033922680     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050018     Document Type: Article

References (29)

1. 1. Andrews NC (1999) Disorders of iron metabolism. New Engl J Med 341:1986-1995
2. 2. Bannerman RM, O'Brein JRP, Witts LJ (1962) Studies in iron metabolism IV. Iron absorption in experimental iron deficiency. Blood 20:532-546
3. 3. Bieri JG, Stoewsand GM, Briggs RW, Phillips JC, Woodard GS, Knapka JJ (1977) Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 107:1340-1348
4. 4. Brittin GM, Raval D (1970) Duodenal ferritin synthesis during iron absorption in the iron-deficient rat. J Lab Invest 75:811-817
5. 5. Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P (1999) Cellular and subcellular localisation of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93:4406-4417
6. 6. Conrad ME, Schade SC (1968) Ascorbate acid chelates in iron absorption: a role for hydrochloric acid and bile. Gastroenterolgy 55:35-45
7. 7. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapatas A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI (2000). Positional cloning of zebra-fish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403:776-781
8. 8. Edwards JA, Hoke JE (1972) Defect of intestinal mucosal iron uptake in mice with hereditary microcytic anaemia. Proc Soc Exp Biol Med 141:81-84
9. 9. Fleming MD, Trenor CC, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16:383-386
10. 10. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95:1148-1153
11. 11. Gunshin H, MacKenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Golan JL, Hediger MA (1997) Cloning and characterisation of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488
12. 12. Harford JB, Rouault TA, Klausner RD (1993) Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72:19-26
13. 13. Kaldor I (1954) Studies on intermediary iron metabolism. V. The measurement of non-haemoglobin tissue iron. Aust J Exp Biol Med Sci 32:795-800
14. 14. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Molecular Cell 5:299-309
15. 15. Müllner EW, Kühn LC (1988) A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell 53:815-825
16. 16. Oates PS, Morgan EH (1996) Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. Am J Physiol 270:826-832
17. 17. Oates PS, Thomas C, Freitas, E, Callow M, Morgan EH (2000) Gene expression of divalent metal transporter I and transferrin receptor in the duodenum of Belgrade rats. Am J Physiol 278 (In press)
18. 18. O'Riordan DK, Sharp PA, Epstein O, Srai SKS, Debman ES (1994) Increased iron transfer in overnight fasted rats (abstract). Gut 35:S52
19. 19. Pollack S, Kaufman RM, Crosby WH (1964) Iron absorption: the effect of an iron deficient diet. Science 144:1015-1016
20. 20. Pountney DJ, Raja KB, Bottwood MJ, Wrigglesworth JM, Simspon RJ (1996) Mucosal surface ferricyanide reductase activity in mouse duodenum Biometals 9:15-20
21. 21. Schümann K, Moret R, Künzle H, Kühn LC (1999) Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Eur J Biochem 260:362-372
22. 3+ uptake. Biochem Biophys Acta 856:115-122
23. 23. Su, MA, Trenor CC, Fleming JC, Fleming MD, Andrews NC (1998) The G185R mutation disrupts function of the iron transporter Nramp2. Blood 92:2157-2163
24. 24. Topham RW, Eads CE, Butler BF (1992) Alterations in the mucosal processing of iron in response to very-short-term dietary iron depletion and repletion. Biochem J 284:877-884
25. 25. Tandy S, Williams M, Leggett A, Lopez-Jimenez M, Dedes M, Ramesh B, Sria SK, Sharp P (2000) Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal cells. J Biol Chem 275:1023-1029
26. 26. Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH (2000) Localisation of DMT1 to the microvillus membrane of rat duodenal enterocytes in iron deficiency but to hepatocytes in iron overload. Gut 45:270-276
27. 27. Warner GT, Oliver R (1962) A plastic phosphor well counter for sample volumes up to 400 ml. Br J Radiol 35:349-352
28. 28. Wheby MS, Crosby WH (1963) The gastrointestinal tract and iron absorption. Blood 22:416-428
29. 59Fe: can the Fe content of duodenal mucosal cells cause lumen or mucosal radioisotope dilution, or both, thus resulting in the underestimation of Fe absorption? Br J Nutr 62:719-727