Role of nitric oxide and Ca++-dependent K+ channels in mediating heterogeneous microvascular responses to acetylcholine in different vascular beds

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1473-1479

  Clark, Shawn G ^a   Fuchs, Leslie C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; APAMIN; CALCIUM ION; CHARYBDOTOXIN; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; INDOMETACIN; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; PROSTACYCLIN; THROMBOXANE A2;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CHANNEL GATING; CONTROLLED STUDY; CORONARY ARTERY; MALE; MESENTERIC ARTERY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; SYRIAN HAMSTER;

ACETYLCHOLINE; ANIMALS; BIOLOGICAL FACTORS; CALCIUM; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MESOCRICETUS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNELS; VASODILATION;

EID: 0030955358     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. ABRAHAMS, V. C., HILTON, S. M. AND ZBROZYNA, A.: Active muscle vasodilation produced by stimulation of the brain stem: Its significance in the defense reaction. J. Physiol. (Lond.) 154: 491-513, 1960
2. ARCHER, S. L., HUANG, J. M. C., REEVE, H. L., HAMPL, V., TOLAROVA, S., MICHELAKIS, E. AND WEIR, E. K: Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ. Res. 78: 431-442, 1996.
3. + channels regulate myogenic tone in the resting state of arteries from spontaneously hypertensive rats. Br. J. Pharmacol. 108: 214-222, 1993.
4. 450-derived arachidonic acid metabolite in the coronary microcirculation. Br. J. Pharmacol. 113: 1548-1553, 1994.
5. CAMPBELL, W. B., GEBREMEDHIN, D., PRATT, P. F. AND HARDER, D. R.: Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 78: 415-423, 1996.
6. 450 enzyme activity. Circ. Res. 79: 827-833, 1996.
7. 450-mono-oxygenase and endothelium-dependent hyperpolarizations in the guinea-pig isolated carotid artery. Br. J. Pharmacol. 117: 607-610, 1996a.
8. CORRIU, C., FÉLÉTOU, M., CANET, E. AND VANHOUTTE, P. M.: Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. Br. J. Pharmacol. 119: 959-964, 1996b.
9. COWAN, C. L., PALACINO, J. J., NAJIBI, S. AND COHEN, R. A.: Potassium channel-mediated relaxation to acetylcholine in rabbit arteries. J. Pharmacol. Exp. Ther. 266: 1482-1489, 1993.
10. FÉLÉTOU, M. AND VANHOUTTE, P. M.: Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br. J. Pharmacol. 93: 515-524, 1988.
11. FERRER, M., ENCABO, A., CONDE, M. V., MARIN, J. AND BALFAGON, G.: Heterogeneity of endothelium-dependent mechanisms in different rabbit arteries. J. Vasc. Res. 32: 339-346, 1995.
12. FUCHS, L. C.: Superoxide anions contribute to impaired endothelium-dependent relaxation in coronary arteries of young cardiomyopathic hamsters. Endothelium 4: 141-149, 1996.
13. FURCHGOTT, R. F. AND ZAWADZKI, J. V.: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 299: 373-376, 1980.
14. GALLE, J., BUSSE, R. AND BASSENGE, E.: Hypercholesterolemia and atherosclerosis change vascular reactivity in rabbits by different mechanisms. Arterioscler. Thromb. 11: 1712-1718, 1991.
15. GALLE, J., BAUERSACHS, J., BASSENGE, E. AND BUSSE, R.: Arterial size determines the enhancement of contractile responses after suppression of endothelium-derived relaxing factor formation. Pflugers Arch. 422: 564-569, 1993.
16. GRUETTER, C. A., GRUETTER, D. Y., LYON, J. E., KADOWITZ, P. J. AND IGNARRO, L. J.: Relationship between cyclic guanosine 3′:5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: Effects of methylene blue and methemoglobin. J. Pharmacol. Exp. Ther. 219: 181-186, 1981.
17. GUMKOWSKI, F., KAMINSKA, G., KAMINSKI, M., MORRISSEY, L. W. AND AUERBACH, R.: Heterogeneity of mouse vascular endothelium. In vitro studies of lymphatic, large blood vessel and microvascular endothelial cells. Blood Vessels 24: 11-23, 1987.
18. HWA J. J., GHIBAUDI, L., WILLIAMS, P. AND CHATTERJEE, M.: Comparison of acetylcholine-dependent relaxations in large and small arteries of rat mesenteric vascular bed. Am. J. Physiol. 266: H952-H958, 1994.
19. + channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide. J. Pharmacol. Exp. Ther. 267: 1327-1335, 1993.
20. LUSCHER, T. F. AND VANHOUTTE, P. M.: The Endothelium: Modulator of Cardiovascular Function. CRC Press, Boca Raton, FL, 1990.
21. MILLER, V. M. AND VANHOUTTE, P. M.: Endothelium-dependent contractions to arachidonic acid are mediated by products of cyclooxygenase. Am. J. Physiol. 248: H432-H437, 1985.
22. MOMBOULI, J., BISSIRIOU, I., AGBOTON, V. D. AND VANHOUTTE, P. M.: Bioassay of endothelium-derived hyperpolarizing factor. Biochem. Biophys. Res. Commun. 221: 484-488, 1996.
23. 2 and prostacyclin. Pharmacol. Rev. 30: 293-331, 1979.
24. MURPHY, M. E. AND BRAYDEN, J. E.: Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J. Physiol. 486: 47-58, 1995a.
25. + channels mediate endothelium-dependent hyperpolarization in rabbit mesenteric arteries. J. Physiol. 489: 723-734, 1995b.
26. G-nitro-L-arginine in rats. Am. J. Physiol. 263: H1090-H1094, 1992.
27. O'MURCHU, B., MILLER, V. M., PERRELLA, M. A. AND BURNETT, J. C. JR.: Increased production of nitric oxide in coronary arteries during congestive heart failure. J. Clin. Invest. 93: 165-171, 1994.
28. O'ROURKE, S. T.: Effects of potassium channel blockers on resting tone in isolated coronary arteries. J. Cardiovasc. Pharmacol. 27: 636-642, 1996.
29. PALMER, R. M. J., ASHTOU, D. S. AND MONCADA, S.: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 383: 664-666, 1988.
30. VERBEUREN, T. J., JORDAENS, F. H., ZONNEKEYN, L. L., VAN HOVE, C. E., COENE, M. C. AND HERMAN, A. G.: Effect of hypercholesterolemia on vascular reactivity in the rabbit. Circ. Res. 58: 552-564, 1986.
31. WEINTRAUB, N. L., STEPHENSON, A. H., SPRAGUE, R. S., MCMURDO, L. AND LONIGRO, A. J.: Relationship of arachidonic acid release to porcine coronary artery relaxation. Hypertension 26: 684-690, 1995.
32. WINQUIST, R. J., HEANEY, L. A., WALLACE, A. A., BASKIN, E. R. STEIN, R. B., GARCIA, M. L. AND KACZOROWSKI, G. J.: Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle. J. Pharmacol. Exp. Ther. 248: 149-156, 1989.
33. WRIGHT, C. E. AND FOZARD, J. R.: Differences in regional vascular sensitivity to endothelin-1 between spontaneously hypertensive and normotensive Wistar Kyoto rate. Br. J. Pharmacol. 100: 107-113, 1990.
34. WU, C., CHEN, S. AND YEN, M.: Different responses to acetylcholine in the presence of nitric oxide inhibitor in rat aortae and mesenteric arteries. Clin. Exp. Pharmacol. Physiol. 20: 405-112, 1993.
35. 450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br. J. Pharmacol. 118: 1147-1152, 1996.