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Volumn 21, Issue 7, 2000, Pages 655-659

Apoptosis induced by 5-flucytosine in human pancreatic cancer cells genetically modified to express cytosine deaminase

Author keywords

Apoptosis; Cytosine deaminase; DNA fragmentation; Flow cytometry; Flucytosine; Fluorouracil; Gene therapy; Pancreatic neoplasms

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE;

EID: 0033912542     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (12)
  • 1
    • 0031708742 scopus 로고    scopus 로고
    • Review article; current treatment and optimal patient management in pancreatic cancer
    • Haycox A, Lombard M, Neoptolemos J, Walley T. Review article; current treatment and optimal patient management in pancreatic cancer. Aliment Pharmacol Ther 1998; 12: 919-61.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 919-961
    • Haycox, A.1    Lombard, M.2    Neoptolemos, J.3    Walley, T.4
  • 2
    • 0032937302 scopus 로고    scopus 로고
    • Treatment of cancer of the exocrine pancreas
    • Huguier M, Mason NP. Treatment of cancer of the exocrine pancreas. Am J Surg 1999; 177: 257-65.
    • (1999) Am J Surg , vol.177 , pp. 257-265
    • Huguier, M.1    Mason, N.P.2
  • 3
    • 0032806082 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy for pancreatic cancer
    • Rigg AS, Lemoine MR. Genetic prodrug activation therapy for pancreatic cancer. Ann NY Acad Sci 1999; 880: 319-25.
    • (1999) Ann NY Acad Sci , vol.880 , pp. 319-325
    • Rigg, A.S.1    Lemoine, M.R.2
  • 4
    • 0027523517 scopus 로고
    • A first step in the development of gene therapy for colorectal carcinoma cloning, sequencing and expression of Escherichia coli cytosine deaminase
    • Austin EA, Huber BE. A first step in the development of gene therapy for colorectal carcinoma cloning, sequencing and expression of Escherichia coli cytosine deaminase. Mol Pharmacol 1993; 43: 380-7.
    • (1993) Mol Pharmacol , vol.43 , pp. 380-387
    • Austin, E.A.1    Huber, B.E.2
  • 5
    • 12944290256 scopus 로고    scopus 로고
    • Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine
    • Zhang LH, Zheng WD, Ling WY, Bin GU, Zhi GH, Qin LY, et al. Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine. Acta Pharmacol Sin 1999; 20: 410-4.
    • (1999) Acta Pharmacol Sin , vol.20 , pp. 410-414
    • Zhang, L.H.1    Zheng, W.D.2    Ling, W.Y.3    Bin, G.U.4    Zhi, G.H.5    Qin, L.Y.6
  • 6
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber BE, Austin EA, Richards CA, Davis ST, Good SS. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA 1991; 91: 8302-6.
    • (1991) Proc Natl Acad Sci USA , vol.91 , pp. 8302-8306
    • Huber, B.E.1    Austin, E.A.2    Richards, C.A.3    Davis, S.T.4    Good, S.S.5
  • 10
    • 0031043426 scopus 로고    scopus 로고
    • In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene
    • Kanai F, Lan KH, Shiratori Y, Tanaka T, Ohashi M, Okudaira T, et al. In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res 1997; 57: 461-5.
    • (1997) Cancer Res , vol.57 , pp. 461-465
    • Kanai, F.1    Lan, K.H.2    Shiratori, Y.3    Tanaka, T.4    Ohashi, M.5    Okudaira, T.6
  • 11
    • 0028929328 scopus 로고
    • Mechanisms and genes of cellular suicide
    • Steller H. Mechanisms and genes of cellular suicide. Science 1995; 267: 1445-9.
    • (1995) Science , vol.267 , pp. 1445-1449
    • Steller, H.1
  • 12
    • 0029943796 scopus 로고    scopus 로고
    • Monitoring gene therapy with cytosine deaminase: In vitro studies using tritiated-5-fluorocytosine
    • Haberkorn U, Oberdorfer F, Gebert J, Morr I, Haack K, Weber K, et al. Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine. J Nucl Med 1996; 37: 87-94.
    • (1996) J Nucl Med , vol.37 , pp. 87-94
    • Haberkorn, U.1    Oberdorfer, F.2    Gebert, J.3    Morr, I.4    Haack, K.5    Weber, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.