Nonradioactive techniques for measurement of in vitro t-cell proliferation alternatives to the [3H]thymidine incorporation assay

Clinical and Diagnostic Laboratory Immunology

Volumn 7, Issue 4, 2000, Pages 687-692

  Messele, Tsehaynesh ^a   Roos, Marijke T L ^b   Hamann, Dorte ^b   Koot, Maarten ^b   Fontanet, Arnaud L ^a   Miedema, Frank ^b   Schellekens, Peter T A ^b   Rinke De Wit, Tobias F ^a  

^a ETHIOPIAN PUBLIC HEALTH INSTITUTE   (Ethiopia)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD38 ANTIGEN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADP-RIBOSYL CYCLASE; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; CELL DIVISION; FLOW CYTOMETRY; HIV-1; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; NAD+ NUCLEOSIDASE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; T-LYMPHOCYTES;

EID: 0033911707     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.7.4.687-692.2000     Document Type: Article

References (36)

1. Autran, B., G. Carcelain, T. S. Li, C. Blanc, D. Mathez, R. Tubiana, C. Katlama, P. Debre, and J. Leibowitch. 1997. Positive effects on combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 277:112-116.
2. Autran, B., and J. V. Giorgi. 1992. Activated CD8+ cells in HIV-related diseases, p. 171-184. In G. Janossy, B. Autran, and F. Miedema (ed.), Immunodeficiency in HIV infection and AIDS. Karger Basel, Basel, Switzerland.
3. Ballet, J. J., L. J. Coudrec, C. Rabian-Herzog, C. Duval-Roy, F. Janier, M. Danon, J. P. Clauvel, and M. Seligmann. 1988. Impaired T-lymphocyte dependent immune responses to microbial antigens in patients with HIV-1 associated persistent generalized lymphadenopathy. AIDS 2:291-297.
4. Bentin, J., C. Tsoukas, J. A. McCutchan, S. E. Spector, D. D. Richman, and J. H. Vaugfan. 1989. Impairment in T-lymphocyte responses during early infection with the human immunodeficiency virus. J. Clin. Immunol. 9:159-168.
5. Bloemena, E., M. T. L. Roos, J. L. A. M. van Heijst, J. M. J. J. Vossen, and P. T. A. Schellekens. 1989. Whole-blood lymphocyte cultures. J. Immunol. Methods 122:161-167.
6. Castle, S., S. Wilkins, E. Heck, K. Tanzy, and J. Fahey. 1995. Depression in caregivers of demented patients is associated with altered immunity: impaired proliferative capacity, increased CD8+, and a decline in lymphocytes with surface signal transduction molecules (CD38+) and a cytotoxicity marker (CD56+CD8+). Clin. Exp. Immunol. 101:487-493.
7. Cesano, A., S. Visonneau, S. Deaglio, F. Malavasi, and D. Santoli. 1998. Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T-cells. J. Immunol. 160:1106-1115.
8. Clerici, M., N. I. Stocks, R. A. Zajac, R. N. Boswell, D. R. Lucey, C. S. Via, and G. M. Shearer. 1989. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic human immunodeficiency virus-seropositive patients. J. Clin. Investig. 84:1892-1899.
9. De Wolf, F., J. M. A. Lange, J. T. M. Houweling, R. A. Coutinho, P. T. Schellekens, J. van der Noorda, and J. Goudsmit. 1988. Numbers of CD4+ cells and the levels of core antigens of and antibodies to the human immunodeficiency virus as predictors of AIDS among seropositive homosexual men. J. Infect. Dis. 158:615-622.
10. Dolan, J. M., M. Clerici, S. P. Blatt, C. W. Hendrix, G. P. Melcher, R. N. Boswell, T. M. Freeman, W. Ward, R. Hensley, and G. M. Shearer. 1995. In vitro T-cell function, delayed-type hypersensitivity skin testing and CD4 T-cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus. J. Infect. Dis. 172:79-87.
11. Funaro, A., G. C. Spagnoli, C. M. Ausielo, M. Alessio, S. Roggero, D. Delia, M. Zaecolo, and F. Malavasi. 1990. Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation. J. Immunol. 145:2390-2396.
12. Giorgi, J. V., H. N. Ho, K. Hirji, C. C. Chou, L. E. Hultin, S. O'Rourke, L. Park, J. B. Margolick, J. Ferbas, J. P. Phair, and the Multicenter AIDS Cohort Study Group. 1994. CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA- DR+ CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels. J. Infect. Dis. 170:775-781.
13. Gruters, R. A., F. G. Terpstra, R. De Jong, C. J. M. Van Noesel, R. A. W. Van Lier, and F. Miedema. 1990. Selective loss of T-cell functions in different stages of HIV infections. Eur. J. Immunol. 20:1039-1044.
14. Hofmann, B., K. D. Jakobsen, N. Odum, E. Dickmeiss, P. Platz, L. P. Ryder, C. Pedersen, L. Mathiesen, I. Bygbjerg, V. Faber, and A. Sveffaard. 1989. HIV induced immunodeficiency. Relatively preserved phytohemagglutinin as opposed to decreased pokeweed mitogen responses may be due to possibly preserved responses via CD2/phytohemaglutinin pathway. J. Immunol. 142:1874-1880.
15. Holter, W., O. Majdic, K. Liszka, H. Stockinger, and W. Knapp. 1985. Kinetics of activation antigen expression by in vitro stimulated human T lymphocytes. Cell. Immunol. 90:322-330.
16. Hong, H. N., L. E. Hultin, R. T. Mitsuyasu, J. L. Matud, M. A. Hausner, D. Bockstoce, C. C. Chou, S. O'Rourke, J. M. G. Taylor, and J. V. Giorgi. 1993. Circulating HIV specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J. Immunol. 150:3070-3079.
17. Jackson, G. D., and I. J. Bell. 1990. Isolation of a cDNA encoding the human CD38(T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J. Immunol. 144:2811-2815.
18. Janosy, G., N. Tidman, S. E. Papageorgiou, P. C. Kung, and G. Goldstein. 1981. Distribution of T-lymphocyte subsets in the human bone marrow and thymus: an analysis with monoclonal antibodies. J. Immunol. 126:1608-1613.
19. Kleinbaun, D. G., L. L. Kupper, and K. E. Muller. 1988. Applied regression analysis and other multivariate methods. PWS-Kent Publishing Company, Boston, Mass.
20. Lane, H. C., J. L. Depper, W. C. Greene, G. Whalen, T. A. Waldmann, and A. S. Fauci. 1985. Qualitative analysis of immune function patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 313:79-84.
21. Linsely, P. S., E. A. Clark, and J. A. Ledbetter. 1990. T-cell antigen CD28 mediates adhesion with B-cells by interacting with activation antigen B7/ BB-1. Proc. Natl. Acad. Sci. USA 87:5031-5035.
22. Mahalingam, M., A. Pozniak, T. J. Mcmanus, D. Vergani, and M. Peakman. 1995. Cell cycling in HIV infection: analysis of in vivo activated lymphocytes. Clin. Exp. Immunol. 102:481-486.
23. McCloskey, T. W., T. Cavaliere, S. Bakshi, R. Harper, J. Fagin, N. Kohn, and S. Pahwa. 1997. Immunophenotyping of T lymphocytes by three-color flow cytometry in healthy newborns, children and adults. Clin. Immunol. Immunopathol. 84:46-55.
24. Messele, T., M. Abdulkadir, A. L. Fontanet, B. Petros, D. Hamann, M. Koot, M. T. L. Roos, P. T. A. Schellekens, F. Miedema, and T. F. Rinke de Wit. 1999. Reduced naïve and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin. Exp. Immunol. 115:443-450.
25. Miedema, F., A. J. C. Petit, F. G. Tepstra, J. K. M. E. Schattenkerk, F. De Wolf, B. J. M. Al, M. Roos, J. M. A. Lange, S. A. Danner, J. Goudsmit, and P. T. A. Schellekens. 1988. Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs. J. Clin. Investig. 82:1908-1914.
26. Pakker, N. G., M. T. L. Roos, R. van Leeuwen, M. D. de Jong, M. Koot, P. Reiss, J. M. A. Lange, F. Miedema, S. A. Danner, and P. T. A. Schellekens. 1997. Patterns of T-cell repopulation, virus load reduction, and restoration of T-cell function in HIV-infected persons during therapy with different antiretroviral agents. J. Acquir. Immune Defic. Syndr. 16:318-326.
27. Plaeger, S., H. Z. Bass, P. Nishanian, J. Thomas, N. Aziz, R. Detels, J. King, W. Cumberland, M. Kemeny, and J. Fahey. 1999. The prognostic significance in HIV infection of immune activation represented by cell surface antigen and plasma activation marker changes. Clin. Immunol. 90:238-246.
28. Polk, B. F., R. Fox, R. Brookmeyer, S. Kanchanaraksa, R. Kaslow, R. Visscher, C. Rinaldo, and J. Phair. 1987. Predictors of the acquired immunodeficiency syndrome developing in a cohort of seropositive homosexual men. N. Engl. J. Med. 316:61-66.
29. Prince, H. E., and E. R. Jensen. 1991. HIV-relatcd alterations in CD8 cell subsets defined by in vitro survival characteristics. Cell. Immunol. 134:276-286.
30. Reinherz, E. L., P. C. Kung, G. Goldstein, R. H. Levey, and S. F. Schlossman. 1980. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc. Natl. Acad. Sci. USA 77:1588-1592.
31. Roos, M. T. L., F. Miedema, M. Koot, M. Tersmette, W. P. Schaasberg, R. A. Coutinho, and P. T. A. Schellekens. 1995. T-cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus (HIV)-infected asymptomatic individuals. J. Infect. Dis. 171:531-536.
32. Roos, M. T. L., F. Miedema, A. A. P. Meinesz, N. A. S. M. De Leeuw, N. G. Pakker, J. M. A. Lange, R. A. Coutinho, and P. T. A. Schellekens. 1996. Low T-cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS correlation with decreased CD28 expression. Clin. Exp. Immunol. 105:409-415.
33. Schellekens, P. T. A., M. T. L. Roos, F. De Wolf, J. M. A. Lange, and F. Miedema. 1990. Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for AIDS in HIV-1 infected men. J. Clin. Immunol. 10:121-127.
34. Shearer, G. M., D. C. Bernstein, K. S. K. Tung, C. S. Via, R. Redfield, S. Z. Salahuddin, and R. C. Gallo. 1986. A model for the selective loss of major histocompatibility complex self restricted T-cell immune responses during the development of acquired immune deficiency syndrome (AIDS). J. Immunol. 137:2514-2521.
35. Van Lier, R. A. W., J. H. A. Boot, A. J. Verhoeven, E. R. De Groot, M. A. Brouwer, and L. A. Aarden. 1987. Functional studies with anti-CD3 heavy chain isotypes with variant monoclonal antibodies. J. Immunol. 139:2873-2879.
36. Van Lier, R. A. W., M. Brouwer, and L. A. Aarden. 1988. Signals involved in T-cell activation. T-cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies. Eur. J. Immunol. 18: 167-172.