The importance of inflammatory mechanisms for the development of Alzheimer's disease

Experimental Gerontology

Volumn 34, Issue 3, 1999, Pages 453-461

  Eikelenboom, P ^a   Veerhuis, R ^a  

^a VU University   (Netherlands)

Author keywords

Activated microglia; Acute phase response; Alzheimer's disease; Delirium; Inflammation

Indexed keywords

AMYLOID BETA PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6;

ALZHEIMER DISEASE; ARTICLE; BRAIN DISEASE; COGNITIVE DEFECT; DELIRIUM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOREACTIVITY; INFLAMMATION; LOCUS CERULEUS; MICROGLIA; PRIORITY JOURNAL;

ACUTE-PHASE REACTION; AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BRAIN; HUMANS; INFLAMMATION; SENILE PLAQUES;

EID: 0033015087     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(99)00022-4     Document Type: Article

References (37)

1. Blalock J.E. The syntaxis of immune-neuroendocrine communication. Immunol Today. 94:1994;504-511.
2. Blom M.M.A.A., van Muiswinkel F.L., Eikelenboom P. Mechanisms of inflammation in Alzheimer's disease. Ann Psychiat. 6:1996;111-114.
3. Blennow K., Wallin A., Fredman P., Karlsson I., Gottfries C.G., Svennerholm L. Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors. Acta Neurol Scand. 90:1990;323-326.
4. Breitner J.C. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu Rev Med. 47:1996;401-411.
5. Dickson D.W., Lee S.C., Mattiace L.A., Yen S.C., Brosnan C. Microglia and cytokines in neurological diseases, with special reference to AIDS and Alzheimer's disease. Glia. 7:1993;75-83.
6. Eikelenboom P., Stam F.C. Immunoglobulins and complement factors in senile plaques. Acta Neuropathol. 82:1982;239-242.
7. Eikelenboom P., Zhan S.S., van Gool W.A., Allsop D. Inflammatory mechanisms in Alzheimer's disease. Trends Pharmacol Sci. 94:1994;147-150.
8. Eikelenboom P., Veerhuis R. The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurobiol Aging. 96:1996;673-680.
9. Eikelenboom P., Rozemuller J.M., van Muiswinkel F.L. Inflammation, Alzheimer's disease Relationships between pathogenic mechanisms and clinical expression . Exp Neurol. 154:1998;89-98.
10. Gaskin F., Finley J., Fang Q., Xu S., Fu S.M. Human antibodies reactive with β-amyloid protein in Alzheimer's disease. J Exp Med. 93:1993;1181-1186.
11. Giometto B., Argentiero V., Sanson F., Ongaro G., Tavolato B. Acute phase proteins in Alzheimer's disease. Eur Neurol. 88:1988;30-33.
12. Griffin W.S.T., Sheng J.G., Roberts G.W., Mrak R.E. Interleukin-1 expression in different plaques types in Alzheimer's disease Significance in plaque evolution . J Neuropathol Exp Neurol. 95:1995;276-281.
13. Hofman A., Ott A., Breteler M.M.B., Bots M.L., Slooter A.J.C., van Harskamp F., van Duijn C.M., van Broeckhoven C., Grobbee D.E. Atherosclerosis, apolipoprotein E, the prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet. 349:1997;151-154.
14. Hoogendijk W.J.G., Feenstra M.G.P., Botterblom M.H.A., Gilhuis J., Sommer I.E.C., Kamphorst W., Eikelenboom P., Swaab D.F. Increased activity of surviving locus coeruleus neurons in Alzheimer's disease. Ann Neurol. 45:1999;82-91.
15. Huell M., Straus S., Volk B., Berger M., Bauer J. Interleukin-6 is presentin early stages of plaque formation and is restricted to the brains of Alzheimer's disease. Acta Neuropathol. 95:1995;511-544.
16. Lawlor B.A., Bierer L.M., Ryan R.M., Schmeidler J., Knott P.J., Williams L.L., Mohs R.C., Davis K.L. Plasma 3-methoxy-4-hydrophenylglycol (MHPG) and clinical symptoms in Alzheimer's disease. Biol Psychiat. 95:1995;185-188.
17. Lipowski Z.J. Delirium Acute confusional state . 1990;Oxford University Press, Oxford, UK.
18. Lue L.F., Brachova L., Civin W.H., Rogers J. Inflammation, AJ deposition, neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J Neuropathol Exp Neurol. 55:1996;1083-1088.
19. Maat-Schieman M.L.C., van Duinen S.G., Rozemuller A.J.M., Haan J., Roos R.A.C. Association of vascular amyloid and cells of the mononuclear phagocytes system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer's disease. J Neuropathol Exp Neurol. 97:1997;273-284.
20. Matsubara E., Hirai S., Amari M., Shoji M., Yamaguchi H., Okamoto K., Ishiguro K., Hargaya Y., Wakabayashi K. 1-Antichymotrypsin as a possible biomedical marker for Alzheimer-type dementia. Ann Neurol. 28:1990;561-567.
21. McGeer P.L., Akiyama H., Itagaki S., McGeer E.G. Immune system response in Alzheimer's disease. Can J Neurol Sci. 89:1989;516-527.
22. McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease A review of 17 epidemiologic studies . Neurology. 95:1995;425-432.
23. Molchan S.E., Hill J.L., Mellow A.M., Lawloor R., Martinez R., Sunderland T. The dexamethsone suppression test in Alzheimer's disease and major depression Relationship to dementia severity, depression and CSF monoamines . Int Psychogeriat. 2:1990;99-122.
24. Murray A.M., Levkoff S.E., Wetle T.T., Becket L., Clearly P.D., Scor J.D., Lipsitz L.A., Rowe J.W., Evans D.E. Acute delirium and fuctional decline in the hospitalized elderly patient. J Gerontol. 93:1993;181-186.
25. Raadsheer F.C., van Heerikhuize J.J., Lucassen P.J., Hoogendijk W.J., Tilders F.J., Swaab D.F. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimers disease and depression. Am J Psychiat. 95:1995;1372-1376.
26. Rogers J., Cooper N.R., Webster S., Schultz J., McGeer P.L., Styren S.D., Civin W.H., Brachova L., Bradt B., Lieberburg I. Complement activation by β-amyloid in Alzheimer's disease. Proc Natl Acad Sci USA. 92:1992;10016-10020.
27. Rozemuller J.M., Eikelenboom P., Stam F.C., Beyreuther K., Masters C.L. A4 protein in Alzheimer's disease Primary and secondary cellular events in extracellular amyloid deposition . J Neuropathol Exp Neurol. 89:1989;674-691.
28. Rozemuller J.M., Stam F.C., & Eikelenboom P. Acute phase proteins are present in amorphous plaques in cerebral but not in cerebellar cortex of in patients with Alzheimer's disease. Neurosci Lett. 90:1990;75-78.
29. Selkoe D.J. Normal and abnormol biology of the β-amyloid precursor protein. Annu Rev Neurosci. 94:1994;489-517.
30. Singh V.K., Guthinkonda P. Circulating cytokines in Alzheimer's disease. J Psychiat Res. 97:1997;657-660.
31. Stefano G.B., Bilfinger T.V., Fricchione G.L. The immuno-neuro-link and the macrophage Postcardiotomy delirium, HIV-associated dementia and psychiatry . Prog Neurobiol. 94:1994;475-488.
32. Terryberry J.W., Thor G., Peter J.B. Autoantibodies in neurodegenerative diseases Antigen-specific frequencies and intrathecal analysis . Neurobiol Aging. 98:1998;205-216.
33. Verbeek M.M., Eikelenboom P., de Waal R.M.W. Differences between the pathogenesis of senile plaques and congophilic angiopathy in Alzheimer's disease. J Neuropathol Exp Neurol. 56:1997;751-761.
34. Van Dam A.-M., de Vries H.E., Kuiper J., Zijlstra F.J., de Boer A.G., Tiders F.J.H., Berkenbosch F. Interleukin-1 receptors on rat brain endothelial cells a role in neuroimmune interaction? FASEB J. 10:1996;351-356.
35. Vandenabeele W., Fiers W. Is amyloidogenesis during Alzheimer's disease due to an Il-1/Il-6 mediated "acute phase response' in the brain? Immunol Today. 12:1991;217-219.
36. Wick G., Grubeck-Loebenstein B. Primary and secondary alterations of immune reactivity in the elderly. Immunol Rev. 97:1997;171-184.
37. Zhan S.S., Veerhuis R., Kamphorst W., Eikelenboom P. Distribution of β-amyloid associated proteins in plaques in Alzheimer's disease and in non-demented elderly. Neurodegeneration. 4:1995;291-297.