Radiolabeled neuronal nitric oxide synthase inhibitors: Synthesis, in vivo evaluation, and primate PET studies

Journal of Nuclear Medicine

Volumn 41, Issue 8, 2000, Pages 1417-1425

  Pomper, M G ^a   Musachio, J L ^a   Scheffel, U ^a   Macdonald, J E ^a   McCarthy, D J ^a   Reif, D W ^a   Villemagne, V L ^a   Yokoi, F ^a   Dannals, R F ^a   Wong, D F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Baboon; Knockout mice; Nitric oxide synthase; PET; Thiopheneamidine

Indexed keywords

[N (2 METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE 7 YL) 2 THIOPHENECARBOXIMIDAMIDE]; CARBON 11; N [4 [[2 [(PHENYLMETHYL)(METHYL) AMINO]ETHYL]PHENYL] 2 THIOPHENECARBOXIMIDAMIDE]; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; BRAIN BLOOD FLOW; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; DRUG UPTAKE; IN VIVO STUDY; ISOTOPE LABELING; KNOCKOUT MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SYNTHESIS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; ENZYME INHIBITORS; ISOQUINOLINES; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; ORGAN SPECIFICITY; PAPIO; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDROISOQUINOLINES; THIOPHENES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033900318     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Nitric oxide synthases: Properties and catalytic mechanism
2. Isoforms of nitric oxide synthase: Properties, cellular distribution and expressional control
3. Nitric oxide actions in neurochemistry
4. Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase
5. Nitric oxide neurotoxicity
6. Effect of neuronal NO synthase on the cerebral vasodilatory response to somatosensory stimulation
7. Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance
8. Nitric oxide and the cerebral circulation
9. Nitric oxide: A physiologic messenger
10. 5-(1-imino-3-butenyl)-L-ornithine: A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase
11. N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: Structure-activity studies and demonstration of in vivo activity
12. Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase
13. Selective inhibitors of neuronal nitric oxide synthase: Is no NOS really good NOS for the nervous system?
14. Amidines are potent inhibitors of nitric oxide synthases: Preferential inhibition of the inducible isoform
15. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
16. 18F]fluoroethylisothiourea, as potential positron emission tomography tracers
17. Synthesis, in vivo evaluation and PET study of a carbon-11-labeled neuronal nitric oxide synthase (nNOS) inhibitor S-methyl-L-thiocitrulline
18. 11C]methyl ester, a nitric oxide synthase inhibitor
19. Amidine derivatives with nitric oxide synthase activities
20. Targeted disruption of the neuronal nitric oxide synthase gene
21. N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases
22. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles
23. Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo
24. 15O autoradiographic method and dynamic PET
25. Anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography
26. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography
27. 11C]scopolamine and positron emission tomography
28. An algorithm for least squares estimation on nonlinear parameters
29. 3H]L-NG nitro-arginine binding in rat brain
30. 3H]L-NG-nitro-arginine autoradiography
31. 3H]arginine binding properties of neuronal nitric oxide synthase in rat brain
32. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: Effects upon local cerebral blood flow and glucose use in the rat
33. Differential action of 7-nitro indazole on rat brain nitric oxide synthase
34. 7-Nitroindazole inhibits brain nitric oxide synthase and cerebral vasodilatation in response to N-methyl-D-aspartate
35. MK-801 (dizocilpine) protects the brain from repeated normothermic global ischemic insults in the rat
36. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography
37. 18F]fluorodeoxy-glucose liver uptake in a c-myc transgenic mouse with positron projection imaging: A feasibility study
38. 3H]L-NG-nitro-arginine autoradiography
39. 741 of the calmodulin-binding domain of the neuronal nitric oxide synthase (NOS-I) prevents binding of calmodulin